C5aR2 deficiency ameliorates inflammation in murine epidermolysis bullosa acquisita by regulating FcγRIIb expression on neutrophils

Fcγ Receptor IIB Controls Skin Inflammation in an Active Model of Epidermolysis Bullosa Acquisita

(2020) Balint Kovacs et al.   Frontiers in Immunology

Recent progresses and perspectives in autoimmune bullous diseases

(2020) Christian D. Sadik et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Absence of the C5a Receptor C5aR2 Worsens Ischemic Tissue Injury by Increasing C5aR1-Mediated Neutrophil Infiltration

(2020) Mike C. L. Wu et al.   JOURNAL OF IMMUNOLOGY

Atypical complement receptor C5aR2 transports C5a to initiate neutrophil adhesion and inflammation

(2019) Yoshishige Miyabe et al.   Science Immunology

Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury–induced inflammation and fibrosis

(2018) Anja Thorenz et al.   KIDNEY INTERNATIONAL

The critical role of C5a as an initiator of neutrophil-mediated autoimmune inflammation of the joint and skin

(2018) Christian D. Sadik et al.   SEMINARS IN IMMUNOLOGY

Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice

(2018) Sidonia Mihai et al.   Frontiers in Immunology

Tissue Destruction in Bullous Pemphigoid Can Be Complement Independent and May Be Mitigated by C5aR2

(2018) Christian M. Karsten et al.   Frontiers in Immunology

In vitro and in vivo models to investigate the pathomechanisms and novel treatments for pemphigoid diseases

(2017) Katja Bieber et al.   EXPERIMENTAL DERMATOLOGY

Critical role for complement receptor C5aR2 in the pathogenesis of renal ischemia-reperfusion injury

(2017) Felix Poppelaars et al.   FASEB JOURNAL

Monitoring C5aR2 Expression Using a Floxed tdTomato-C5aR2 Knock-In Mouse

(2017) Christian M. Karsten et al.   JOURNAL OF IMMUNOLOGY

The Leukotriene B 4 and its Receptor BLT1 Act as Critical Drivers of Neutrophil Recruitment in Murine Bullous Pemphigoid-Like Epidermolysis Bullosa Acquisita

(2017) Tanya Sezin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling

(2016) Daniel E Croker et al.   IMMUNOLOGY AND CELL BIOLOGY

Epidermolysis Bullosa Acquisita: From Pathophysiology to Novel Therapeutic Options

(2016) Michael Kasperkiewicz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

T cells mediate autoantibody-induced cutaneous inflammation and blistering in epidermolysis bullosa acquisita

(2016) Katja Bieber et al.   Scientific Reports

Radiosensitive Hematopoietic Cells Determine the Extent of Skin Inflammation in Experimental Epidermolysis Bullosa Acquisita

(2015) Hiroaki Iwata et al.   JOURNAL OF IMMUNOLOGY

Fcγ Receptors III and IV Mediate Tissue Destruction in a Novel Adult Mouse Model of Bullous Pemphigoid

(2014) Franziska S. Schulze et al.   AMERICAN JOURNAL OF PATHOLOGY

C5a2 can modulate ERK1/2 signaling in macrophages via heteromer formation with C5a1 and β-arrestin recruitment

(2014) Daniel E Croker et al.   IMMUNOLOGY AND CELL BIOLOGY

Update on the pathogenesis of bullous pemphigoid: An autoantibody-mediated blistering disease targeting collagen XVII

(2014) Wataru Nishie   JOURNAL OF DERMATOLOGICAL SCIENCE

C5a, but not C5a-des Arg, induces upregulation of heteromer formation between complement C5a receptors C5aR and C5L2

(2013) Daniel E Croker et al.   IMMUNOLOGY AND CELL BIOLOGY

GM-CSF Modulates Autoantibody Production and Skin Blistering in Experimental Epidermolysis Bullosa Acquisita

(2013) U. K. S. R. L. Samavedam et al.   JOURNAL OF IMMUNOLOGY

Disruption of the Complement Anaphylatoxin Receptor C5L2 Exacerbates Inflammation in Allergic Contact Dermatitis

(2013) R. Wang et al.   JOURNAL OF IMMUNOLOGY

The immunoglobulin, IgG Fc receptor and complement triangle in autoimmune diseases

(2012) Christian M. Karsten et al.   IMMUNOBIOLOGY

Genetic identification and functional validation of FcγRIV as key molecule in autoantibody-induced tissue injury

(2012) Michael Kasperkiewicz et al.   JOURNAL OF PATHOLOGY

Pemphigoid diseases

(2012) Enno Schmidt et al.   LANCET

Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1

(2012) Christian M Karsten et al.   NATURE MEDICINE

Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and Fc R signaling

(2012) C. D. Sadik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid-Cytokine-Chemokine Cascade Drives Neutrophil Recruitment in a Murine Model of Inflammatory Arthritis

(2010) Richard C. Chou et al.   IMMUNITY

The C5a Receptor (C5aR) C5L2 Is a Modulator of C5aR-mediated Signal Transduction

(2010) Claire E. Bamberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Critical Role for C5L2 in the Pathogenesis of Experimental Allergic Asthma

(2010) X. Zhang et al.   JOURNAL OF IMMUNOLOGY

FcγRIIA and FcγRIIIB Are Required for Autoantibody-Induced Tissue Damage in Experimental Human Models of Bullous Pemphigoid

(2010) Xinhua Yu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma

(2010) Stephane Lajoie et al.   NATURE IMMUNOLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Functional roles for C5a receptors in sepsis

(2008) Daniel Rittirsch et al.   NATURE MEDICINE