Leptin Augments Antitumor Immunity in Obesity by Repolarizing Tumor-Associated Macrophages

Leptin Receptor (LEPR) promotes proliferation, migration, and invasion and inhibits apoptosis in hepatocellular carcinoma by regulating ANXA7

(2021) He Huang et al.   Cancer Cell International

Incendiary Leptin

(2020) Patricia Seoane-Collazo et al.   Nutrients

Immune gene signatures for predicting durable clinical benefit of anti-PD-1 immunotherapy in patients with non-small cell lung cancer

(2020) Sohyun Hwang et al.   Scientific Reports

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

(2020) Alison E. Ringel et al.   CELL

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

(2019) Xianjie Jiang et al.   Molecular Cancer

Interaction of tumor-associated macrophages and cancer chemotherapy

(2019) Irina Larionova et al.   OncoImmunology

Obesity-Associated Extracellular Matrix Remodeling Promotes a Macrophage Phenotype Similar to Tumor-Associated Macrophages

(2019) Nora L. Springer et al.   AMERICAN JOURNAL OF PATHOLOGY

Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications

(2019) Yuxin Lin et al.   Journal of Hematology & Oncology

Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance

(2019) Dayana B. Rivadeneira et al.   IMMUNITY

Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis

(2018) Jennifer L McQuade et al.   LANCET ONCOLOGY

Obesity, Fat Mass and Immune System: Role for Leptin

(2018) Vera Francisco et al.   Frontiers in Physiology

Targeting Macrophages in Cancer: From Bench to Bedside

(2018) Ashleigh R. Poh et al.   Frontiers in Oncology

Regulation of iNOS on Immune Cells and Its Role in Diseases

(2018) Qingjie Xue et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

(2018) Ziming Wang et al.   NATURE MEDICINE

Foundations of Immunometabolism and Implications for Metabolic Health and Disease

(2017) Gökhan S. Hotamisligil   IMMUNITY

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

SCENIC: single-cell regulatory network inference and clustering

(2017) Sara Aibar et al.   NATURE METHODS

Inflammation and the Metabolic Syndrome: The Tissue-Specific Functions of NF-κB

(2017) Leen Catrysse et al.   TRENDS IN CELL BIOLOGY

Emerging Concepts Linking Obesity with the Hallmarks of Cancer

(2017) Claire L. Donohoe et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Obesity, Inflammation, and Cancer

(2016) Tuo Deng et al.   Annual Review of Pathology-Mechanisms of Disease

Obesity and Cancer Mechanisms: Tumor Microenvironment and Inflammation

(2016) Neil M. Iyengar et al.   JOURNAL OF CLINICAL ONCOLOGY

Body Fatness and Cancer — Viewpoint of the IARC Working Group

(2016) Béatrice Lauby-Secretan et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Macrophage Switch in Obesity Development

(2016) Angela Castoldi et al.   Frontiers in Immunology

A Threshold Level of Intratumor CD8 + T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1

(2015) Shin Foong Ngiow et al.   CANCER RESEARCH

Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages

(2015) Yi Zhou et al.   Cell Metabolism

T-cell exhaustion in the tumor microenvironment

(2015) Y Jiang et al.   Cell Death & Disease

Macrophages associated with tumors as potential targets and therapeutic intermediates

(2014) Serguei Vinogradov et al.   Nanomedicine

Obesity induced a leptin-Notch signaling axis in breast cancer

(2013) Monica Battle et al.   INTERNATIONAL JOURNAL OF CANCER

Macrophages and chemokines as mediators of angiogenesis

(2013) Jennifer L. Owen et al.   Frontiers in Physiology

NF-κB and the link between inflammation and cancer

(2012) Joseph A. DiDonato et al.   IMMUNOLOGICAL REVIEWS

Inflammation meets cancer, with NF-κB as the matchmaker

(2011) Yinon Ben-Neriah et al.   NATURE IMMUNOLOGY

Energy balance modulates colon tumor growth: Interactive roles of insulin and estrogen

(2010) Elizabeth A. Rondini et al.   MOLECULAR CARCINOGENESIS