Functions, mechanisms, and therapeutic implications of METTL14 in human cancer

Decreased expression of METTL14 predicts poor prognosis and construction of a prognostic signature for clear cell renal cell carcinoma

(2021) Yi Wang et al.   Cancer Cell International

Establishment of a Risk Signature Based on m6A RNA Methylation Regulators That Predicts Poor Prognosis in Renal Cell Carcinoma

(2021) Jingsun Wei et al.   OncoTargets and Therapy

PADI2‐Catalyzed MEK1 Citrullination Activates ERK1/2 and Promotes IGF2BP1‐Mediated SOX2 mRNA Stability in Endometrial Cancer

(2021) Teng Xue et al.   Advanced Science

Effect of N6-Methyladenosine Regulators on Progression and Prognosis of Triple-Negative Breast Cancer

(2021) Shanshan Wang et al.   Frontiers in Genetics

Comprehensive Analysis of Expression Regulation for RNA m6A Regulators With Clinical Significance in Human Cancers

(2021) Xiaonan Liu et al.   Frontiers in Oncology

m6A Regulators Is Differently Expressed and Correlated With Immune Response of Esophageal Cancer

(2021) Huaying Zhao et al.   Frontiers in Cell and Developmental Biology

USP48 is upregulated by Mettl14 to attenuate hepatocellular carcinoma via regulating SIRT6 stabilization

(2021) Lutao Du et al.   CANCER RESEARCH

CLK1/SRSF5 pathway induces aberrant exon skipping of METTL14 and Cyclin L2 and promotes growth and metastasis of pancreatic cancer

(2021) Shi Chen et al.   Journal of Hematology & Oncology

CircPTPRA blocks the recognition of RNA N6-methyladenosine through interacting with IGF2BP1 to suppress bladder cancer progression

(2021) Fei Xie et al.   Molecular Cancer

m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype

(2021) Pingyu Liu et al.   NATURE CELL BIOLOGY

Immune infiltration-related N6-methyladenosine RNA methylation regulators influence the malignancy and prognosis of endometrial cancer

(2021) Jian Ma et al.   Aging-US

The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth

(2021) Lihui Dong et al.   CANCER CELL

Methyl CpG binding protein 2 promotes colorectal cancer metastasis by regulating N 6 ‐methyladenosine methylation through methyltransferase‐like 14

(2021) Shuo Wang et al.   CANCER SCIENCE

The circular RNA circSPARC enhances the migration and proliferation of colorectal cancer by regulating the JAK/STAT pathway

(2021) Jiaqi Wang et al.   Molecular Cancer

METTL14 facilitates global genome repair and suppresses skin tumorigenesis

(2021) Zizhao Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

METTL14 promotes tumorigenesis by regulating lncRNA OIP5-AS1/miR-98/ADAMTS8 signaling in papillary thyroid cancer

(2021) Xiaoping Zhang et al.   Cell Death & Disease

Prognostic Implication of the m6A RNA Methylation Regulators in Rectal Cancer

(2021) Yajie Chen et al.   Frontiers in Genetics

m6A Methyltransferase METTL14-Mediated Upregulation of Cytidine Deaminase Promoting Gemcitabine Resistance in Pancreatic Cancer

(2021) Congjun Zhang et al.   Frontiers in Oncology

LncRNA HCG11 mediated by METTL14 inhibits the growth of lung adenocarcinoma via IGF2BP2/LATS1

(2021) Jun Mao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

METTL14 gene polymorphisms decrease Wilms tumor susceptibility in Chinese children

(2021) Zhenjian Zhuo et al.   BMC CANCER

Isorhapontigenin (ISO) inhibits EMT through FOXO3A/METTL14/VIMENTIN pathway in bladder cancer cells

(2021) Ning Zhang et al.   CANCER LETTERS

Methyltransferase‐like 14 suppresses growth and metastasis of renal cell carcinoma by decreasing long noncoding RNA NEAT1

(2021) Tao Liu et al.   CANCER SCIENCE

Genetic Variants in METTL14 are Associated with the Risk of Acute Lymphoblastic Leukemia in Southern Chinese Children: A Five-Center Case-Control Study

(2021) Ailing Luo et al.   Cancer Management and Research

N6-Methyladenosine Methyltransferase METTL14-Mediated Autophagy in Malignant Development of Oral Squamous Cell Carcinoma

(2021) Fang Wang et al.   Frontiers in Oncology

The N 6 -methyladenosine (m6 A) erasers alkylation repair homologue 5 (ALKBH5) and fat mass and obesity-associated protein (FTO) are prognostic biomarkers in patients with clear cell renal carcinoma

(2020) Alexander Strick et al.   BJU INTERNATIONAL

M6A-mediated upregulation of LINC00958 increases lipogenesis and acts as a nanotherapeutic target in hepatocellular carcinoma

(2020) Xueliang Zuo et al.   Journal of Hematology & Oncology

The emerging roles of N6-methyladenosine (m6A) deregulation in liver carcinogenesis

(2020) Mengnuo Chen et al.   Molecular Cancer

METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST

(2020) Xiao Yang et al.   Molecular Cancer

The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation

(2020) Tao Liu et al.   NUCLEIC ACIDS RESEARCH

Identification of three m6A‐related mRNAs signature and risk score for the prognostication of hepatocellular carcinoma

(2020) Zedong Li et al.   Cancer Medicine

A five-gene signature derived from m6A regulators to improve prognosis prediction of neuroblastoma

(2020) Zhichao Wang et al.   Cancer Biomarkers

m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer

(2020) Huilin Huang et al.   CANCER CELL

Identification of a m6A RNA methylation regulators-based signature for predicting the prognosis of clear cell renal carcinoma

(2020) Jing Chen et al.   Cancer Cell International

Identification and validation of m6A RNA methylation regulators with clinical prognostic value in Papillary thyroid cancer

(2020) Xinyi Wang et al.   Cancer Cell International

The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs

(2020) Valentina V. Ignatova et al.   GENES & DEVELOPMENT

Downregulation of METTL14 increases apoptosis and autophagy induced by cisplatin in pancreatic cancer cells

(2020) Fanhua Kong et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Insights into the Regulatory Role of m6A Epitranscriptome in Glioblastoma

(2020) Silvia Galardi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner

(2020) Xingya Guo et al.   Molecular Cancer

The potential role of RNA N6-methyladenosine in Cancer progression

(2020) Tianyi Wang et al.   Molecular Cancer

Dysregulated m6A-Related Regulators Are Associated With Tumor Metastasis and Poor Prognosis in Osteosarcoma

(2020) Jianhao Li et al.   Frontiers in Oncology

METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer

(2020) Xiaoxiang Chen et al.   Molecular Cancer

LNC942 promoting METTL14-mediated m6A methylation in breast cancer cell proliferation and progression

(2020) Tong Sun et al.   ONCOGENE

ALKBH5 regulates anti–PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment

(2020) Na Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA N6-methyladenosine modification is required for miR-98/MYCN axis-mediated inhibition of neuroblastoma progression

(2020) Junmei Cheng et al.   Scientific Reports

Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells

(2020) Fei Peng et al.   CELL RESEARCH

Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer

(2020) Min Wang et al.   Molecular Cancer

m6A-Atlas: a comprehensive knowledgebase for unraveling the N6-methyladenosine (m6A) epitranscriptome

(2020) Yujiao Tang et al.   NUCLEIC ACIDS RESEARCH

A Role for N6-Methyladenine in DNA Damage Repair

(2020) Xing Zhang et al.   TRENDS IN BIOCHEMICAL SCIENCES

The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells

(2020) Deobrat Dixit et al.   Cancer Discovery

YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis

(2020) Guoqiang Chang et al.   CANCER CELL

METTL14 Gene Polymorphisms Confer Neuroblastoma Susceptibility: An Eight-Center Case-Control Study

(2020) Zhenjian Zhuo et al.   Molecular Therapy-Nucleic Acids

METTL14 Inhibits Hepatocellular Carcinoma Metastasis Through Regulating EGFR/PI3K/AKT Signaling Pathway in an m6A-Dependent Manner

(2020) Yuntao Shi et al.   Cancer Management and Research

Analysis of N6-Methyladenosine Methyltransferase Reveals METTL14 and ZC3H13 as Tumor Suppressor Genes in Breast Cancer

(2020) Peng-Ju Gong et al.   Frontiers in Oncology

Upregulated N6-Methyladenosine RNA in Peripheral Blood: Potential Diagnostic Biomarker for Breast Cancer

(2020) Han Xiao et al.   Cancer Research and Treatment

Analyzing the interactions of mRNAs, miRNAs, lncRNAs and circRNAs to predict competing endogenous RNA networks in osteosarcoma chemo-resistance

(2019) Kun-Peng Zhu et al.   MOLECULAR THERAPY

Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells

(2019) Dali Han et al.   NATURE

Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally

(2019) Huilin Huang et al.   NATURE

RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3

(2019) Yi Niu et al.   Molecular Cancer

Gene signatures and prognostic values of m6A regulators in clear cell renal cell carcinoma – a retrospective study using TCGA database

(2019) Jingcheng Zhou et al.   Aging-US

The role of m6A RNA methylation in cancer

(2019) Ting Sun et al.   BIOMEDICINE & PHARMACOTHERAPY

Changes of N6-methyladenosine modulators promote breast cancer progression

(2019) Lianpin Wu et al.   BMC CANCER

N6-Methyladenosine (m6A): A Promising New Molecular Target in Acute Myeloid Leukemia

(2019) Zaira Ianniello et al.   Frontiers in Oncology

The m6A-suppressed P2RX6 activation promotes renal cancer cells migration and invasion through ATP-induced Ca2+ influx modulating ERK1/2 phosphorylation and MMP9 signaling pathway

(2019) Dongkui Gong et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner

(2019) Jie Han et al.   Molecular Cancer

The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112

(2019) Nhan van Tran et al.   NUCLEIC ACIDS RESEARCH

Reduced m6A modification predicts malignant phenotypes and augmented Wnt/PI3K-Akt signaling in gastric cancer

(2019) Cheng Zhang et al.   Cancer Medicine

WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1

(2019) Yunhao Chen et al.   Molecular Cancer

A global view of hepatocellular carcinoma: trends, risk, prevention and management

(2019) Ju Dong Yang et al.   Nature Reviews Gastroenterology & Hepatology

Reading, writing and erasing mRNA methylation

(2019) Sara Zaccara et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

N6-methyladenosine modification of ITGA6 mRNA promotes the development and progression of bladder cancer

(2019) Huan Jin et al.   EBioMedicine

Mettl14 inhibits bladder TIC self-renewal and bladder tumorigenesis through N6-methyladenosine of Notch1

(2019) Chaohui Gu et al.   Molecular Cancer

METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-Dependent Primary miR-375 Processing

(2019) Xiaoxiang Chen et al.   MOLECULAR THERAPY

Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA

(2019) Wendan Ren et al.   Nature Communications

The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA

(2019) Rita Pinto et al.   NUCLEIC ACIDS RESEARCH

Integrative network analysis identifies cell-specific trans regulators of m6A

(2019) Sanqi An et al.   NUCLEIC ACIDS RESEARCH

Human MettL3–MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro

(2019) Clayton B. Woodcock et al.   Cell Discovery

RNA N6-methyladenosine modification in cancers: current status and perspectives

(2018) Xiaolan Deng et al.   CELL RESEARCH

Meddling with METTLs in Normal and Leukemia Stem Cells

(2018) Gaëlle H. Martin et al.   Cell Stem Cell

METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m 6 A Modification

(2018) Hengyou Weng et al.   Cell Stem Cell

Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d

(2018) Philip Knuckles et al.   GENES & DEVELOPMENT

RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2

(2018) Mengnuo Chen et al.   HEPATOLOGY

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

(2018) Huilin Huang et al.   NATURE CELL BIOLOGY

N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications

(2018) Yang Wang et al.   NATURE NEUROSCIENCE

SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function

(2018) Yuzhang Du et al.   NUCLEIC ACIDS RESEARCH

Interactions, localization, and phosphorylation of the m 6 A generating METTL3–METTL14–WTAP complex

(2018) Eva Schöller et al.   RNA

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

N6-methyladenosine links RNA metabolism to cancer progression

(2018) Dongjun Dai et al.   Cell Death & Disease

Structural Insights into N 6 -methyladenosine (m 6 A) Modification in the Transcriptome

(2018) Jinbo Huang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

(2018) Yanan Yue et al.   Cell Discovery

FTO regulates adipogenesis by controlling cell cycle progression via m6A-YTHDF2 dependent mechanism

(2018) Ruifan Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer

(2018) Jun Liu et al.   NATURE CELL BIOLOGY

The Role of m6A/m-RNA Methylation in Stress Response Regulation

(2018) Mareen Engel et al.   NEURON

RNA m6A modification and its function in diseases

(2018) Jiyu Tong et al.   Frontiers of Medicine

N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation

(2018) Honghui Ma et al.   Nature Chemical Biology

m6A modification controls the innate immune response to infection by targeting type I interferons

(2018) Roni Winkler et al.   NATURE IMMUNOLOGY

Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs

(2018) Zhuojia Chen et al.   NUCLEIC ACIDS RESEARCH

Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis

(2017) Liping Li et al.   HUMAN MOLECULAR GENETICS

m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways

(2017) Hua-Bing Li et al.   NATURE

RNA m6A methylation regulates the ultraviolet-induced DNA damage response

(2017) Yang Xiang et al.   NATURE

The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells

(2017) Ly P Vu et al.   NATURE MEDICINE

N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein

(2017) Nian Liu et al.   NUCLEIC ACIDS RESEARCH

m 6 A in mRNA: An Ancient Mechanism for Fine-Tuning Gene Expression

(2017) Jean-Yves Roignant et al.   TRENDS IN GENETICS

m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

(2017) Qi Cui et al.   Cell Reports

AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells

(2017) Yuko Ueda et al.   Scientific Reports

METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulatingN6-methyladenosine-dependent primary MicroRNA processing

(2016) Jin-zhao Ma et al.   HEPATOLOGY

Structures of the m 6 A Methyltransferase Complex: Two Subunits with Distinct but Coordinated Roles

(2016) Katherine I. Zhou et al.   MOLECULAR CELL

Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing

(2016) Wen Xiao et al.   MOLECULAR CELL

Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases

(2016) Ping Wang et al.   MOLECULAR CELL

The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells

(2016) Shuibin Lin et al.   MOLECULAR CELL

Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex

(2016) Xiang Wang et al.   NATURE

m6A RNA methylation promotes XIST-mediated transcriptional repression

(2016) Deepak P. Patil et al.   NATURE

Non-coding RNAs as drug targets

(2016) Masayuki Matsui et al.   NATURE REVIEWS DRUG DISCOVERY

Post-transcriptional gene regulation by mRNA modifications

(2016) Boxuan Simen Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

N6-methyladenosine–encoded epitranscriptomics

(2016) Nian Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

N6-methyladenosine–encoded epitranscriptomics

(2016) Nian Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural insights into the molecular mechanism of the m6A writer complex

(2016) Paweł Śledź et al.   eLife

5′ UTR m6A Promotes Cap-Independent Translation

(2015) Kate D. Meyer et al.   CELL

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

(2015) Claudio R. Alarcón et al.   CELL

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

(2015) Xiao Wang et al.   CELL

Colorectal cancer

(2015) Herb Brody   NATURE

N6-methyladenosine marks primary microRNAs for processing

(2015) Claudio R. Alarcón et al.   NATURE

Dynamic m6A mRNA methylation directs translational control of heat shock response

(2015) Jun Zhou et al.   NATURE

Widespread occurrence ofN6-methyladenosine in bacterial mRNA

(2015) Xin Deng et al.   NUCLEIC ACIDS RESEARCH

m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

(2015) Shay Geula et al.   SCIENCE

Pathways related to PMA-differentiated THP1 human monocytic leukemia cells revealed by RNA-Seq

(2015) ChengWu Zeng et al.   Science China-Life Sciences

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

(2014) Xu Zhao et al.   CELL RESEARCH

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

Gene expression regulation mediated through reversible m6A RNA methylation

(2014) Ye Fu et al.   NATURE REVIEWS GENETICS

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells

(2011) Kyung-Dal Choi et al.   Nature Protocols