Designing strategies of small-molecule compounds for modulating non-coding RNAs in cancer therapy

Circular RNAs as biomarkers and therapeutic targets in cancer

(2021) Aferin Beilerli et al.   SEMINARS IN CANCER BIOLOGY

Long Noncoding RNAs at the Crossroads of Cell Cycle and Genome Integrity

(2021) Giulia Guiducci et al.   TRENDS IN GENETICS

Long noncoding RNA: A resident staff of genomic instability regulation in tumorigenesis

(2021) Feifei Guo et al.   CANCER LETTERS

Repositioning Azelnidipine as a Dual Inhibitor Targeting CD47/SIRPα and TIGIT/PVR Pathways for Cancer Immuno-Therapy

(2021) Xiuman Zhou et al.   Biomolecules

The role of miR-21/RECK in the inhibition of osteosarcoma by curcumin

(2020) Li Zhou et al.   MOLECULAR AND CELLULAR PROBES

Pan-genomics in the human genome era

(2020) Rachel M. Sherman et al.   NATURE REVIEWS GENETICS

A High-Throughput Screening Identifies MICU1 Targeting Compounds

(2020) Giulia Di Marco et al.   Cell Reports

Carvedilol serves as a novel CYP1B1 inhibitor, a systematic drug repurposing approach through structure-based virtual screening and experimental verification

(2020) Ying Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Hsa_circ_0000515 is a novel circular RNA implicated in the development of breast cancer through its regulation of the microRNA‐296‐5p/CXCL10 axis

(2020) Fenglin Cai et al.   FEBS Journal

The Novel ncRNA OsiR Positively Regulates Expression of katE2 and is Required for Oxidative Stress Tolerance in Deinococcus radiodurans

(2020) Lihua Gao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High-Throughput Screening For The Discovery Of Enzyme Inhibitors

(2020) Matthew D. Lloyd   JOURNAL OF MEDICINAL CHEMISTRY

How We Think about Targeting RNA with Small Molecules

(2020) Matthew G. Costales et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands

(2020) Xiaohui Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Long noncoding RNA SNHG12 induces proliferation, migration, epithelial-mesenchymal transition and stemness of esophageal squamous cell carcinoma cells via post-transcriptional regulation of BMI1 and CTNNB1

(2020) Duoguang Wu et al.   Molecular Oncology

2-O-Methylmagnolol, a Magnolol Derivative, Suppresses Hepatocellular Carcinoma Progression via Inhibiting Class I Histone Deacetylase Expression

(2020) Chi-Yuan Chen et al.   Frontiers in Oncology

Targeting RNA structures in diseases with small molecules

(2020) Yanqiu Shao et al.   Essays in Biochemistry

Critical role of HOX transcript antisense intergenic RNA (HOTAIR) in gliomas

(2020) Efthalia Angelopoulou et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

LncRNA SNAI3-AS1 promotes PEG10-mediated proliferation and metastasis via decoying of miR-27a-3p and miR-34a-5p in hepatocellular carcinoma

(2020) Yarui Li et al.   Cell Death & Disease

Selective small molecule targeting of a triple helix encoded by the long non-coding RNA, MALAT1

(2019) Fardokht A Abulwerdi et al.   ACS Chemical Biology

PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA

(2019) Liping Tan et al.   Molecular Cancer

Targeted design and identification of AC1NOD4Q to block activity of HOTAIR by abrogating the scaffold interaction with EZH2

(2019) Yu Ren et al.   Clinical Epigenetics

Extracellular vesicles secreted by hypoxia pre-challenged mesenchymal stem cells promote non-small cell lung cancer cell growth and mobility as well as macrophage M2 polarization via miR-21-5p delivery

(2019) Weihua Ren et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The Small Non-coding Vault RNA1-1 Acts as a Riboregulator of Autophagy

(2019) Rastislav Horos et al.   CELL

Long noncoding RNA CA7-4 promotes autophagy and apoptosis via sponging MIR877-3P and MIR5680 in high glucose-induced vascular endothelial cells

(2019) Xuan Zhao et al.   Autophagy

HOTAIR/miR-326/FUT6 axis facilitates colorectal cancer progression through regulating fucosylation of CD44 via PI3K/AKT/mTOR pathway

(2019) Shimeng Pan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Small Molecule Inhibition of MicroRNA-21 Expression Reduces Cell Viability and Microtumor Formation

(2019) Nicholas Ankenbruck et al.   BIOORGANIC & MEDICINAL CHEMISTRY

microRNA-21 promotes breast cancer proliferation and metastasis by targeting LZTFL1

(2019) Hui Wang et al.   BMC CANCER

tRNA-derived fragments and tRNA halves: The new players in cancers

(2019) Linwen Zhu et al.   CANCER LETTERS

HOX transcript antisense RNA (HOTAIR) in cancer

(2019) Xiaohan Qu et al.   CANCER LETTERS

The biogenesis, biology and characterization of circular RNAs

(2019) Lasse S. Kristensen et al.   NATURE REVIEWS GENETICS

The SOX4/miR-17-92/RB1 Axis Promotes Prostate Cancer Progression

(2019) Hui Liu et al.   NEOPLASIA

The Role of Non-coding RNAs in Oncology

(2019) Frank J. Slack et al.   CELL

Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune response

(2019) Mahnaz Sahraei et al.   JOURNAL OF CLINICAL INVESTIGATION

Exosomal miR-21 regulates the TETs/PTENp1/PTEN pathway to promote hepatocellular carcinoma growth

(2019) Liang-qi Cao et al.   Molecular Cancer

METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-Dependent Primary miR-375 Processing

(2019) Xiaoxiang Chen et al.   MOLECULAR THERAPY

Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds

(2019) Zhaoyang Li et al.   NATURE

Long Non-Coding RNA HOTAIR Modulates KLF12 to Regulate Gastric Cancer Progression via PI3K/ATK Signaling Pathway by Sponging miR-618

(2019) Jin Xun et al.   OncoTargets and Therapy

Upregulation of miR-17-92 cluster is associated with progression and lymph node metastasis in oesophageal adenocarcinoma

(2019) Patrick Sven Plum et al.   Scientific Reports

Discovery of Selective RNA-Binding Small Molecules by Affinity-Selection Mass Spectrometry

(2018) Noreen F. Rizvi et al.   ACS Chemical Biology

Therapeutic vulnerability of multiple myeloma to MIR17PTi, a first-in-class inhibitor of pri-mir-17-92

(2018) Eugenio Morelli et al.   BLOOD

Functional Classification and Experimental Dissection of Long Noncoding RNAs

(2018) Florian Kopp et al.   CELL

MicroRNA

(2018) Thomas X. Lu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Long non-coding RNA MIAT promotes gastric cancer growth and metastasis through regulation of miR-141/DDX5 pathway

(2018) Min Sha et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Small-Molecule Activator of UNC-51-Like Kinase 1 (ULK1) That Induces Cytoprotective Autophagy for Parkinson’s Disease Treatment

(2018) Liang Ouyang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small Molecule Targeted Recruitment of a Nuclease to RNA

(2018) Matthew G. Costales et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Serum long noncoding RNA HOTAIR as a novel diagnostic and prognostic biomarker in glioblastoma multiforme

(2018) Sze Kiat Tan et al.   Molecular Cancer

NMR-Fragment Based Virtual Screening: A Brief Overview

(2018) et al.   MOLECULES

Principles for targeting RNA with drug-like small molecules

(2018) Katherine Deigan Warner et al.   NATURE REVIEWS DRUG DISCOVERY

Emerging Roles of Non-Coding RNA Transcription

(2018) Minna U. Kaikkonen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Computer-aided drug design and inhibitive effect of a novel nitrogenous heterocyclic compound and its mechanism on glioma U251 cells and breast cancer MCF-7 cells

(2018) Liyu Qian et al.   Drug Design Development and Therapy

Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold

(2018) Anita Donlic et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cobomarsen, an oligonucleotide inhibitor of miR-155, co-ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T-cell lymphoma

(2018) Anita G. Seto et al.   BRITISH JOURNAL OF HAEMATOLOGY

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

(2018) Abhishek Ranaware et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MALAT1 induces osteosarcoma progression by targeting miR-206/CDK9 axis

(2018) Dong Ren et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MicroRNA-122 negatively associates with peroxiredoxin-II expression in human gefitinib-resistant lung cancer stem cells

(2018) Nisansala Chandimali et al.   CANCER GENE THERAPY

Circular RNA YAP1 inhibits the proliferation and invasion of gastric cancer cells by regulating the miR-367-5p/p27 Kip1 axis

(2018) Hui Liu et al.   Molecular Cancer

Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics

(2018) Chunmei Chang et al.   MOLECULAR CELL

Revealing lncRNA Structures and Interactions by Sequencing-Based Approaches

(2018) Xingyang Qian et al.   TRENDS IN BIOCHEMICAL SCIENCES

Drugging the RNA World

(2018) Matthew D. Disney et al.   Cold Spring Harbor Perspectives in Biology

One-Bead–Two-Compound Thioether Bridged Macrocyclic γ-AApeptide Screening Library against EphA2

(2017) Yan Shi et al.   JOURNAL OF MEDICINAL CHEMISTRY

RNA-MoIP: prediction of RNA secondary structure and local 3D motifs from sequence data

(2017) Jason Yao et al.   NUCLEIC ACIDS RESEARCH

Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo

(2017) Lan Zhang et al.   Chemical Science

2-O-Methylmagnolol upregulates the long non-coding RNA, GAS5 and enhances apoptosis in skin cancer cells

(2017) Tong-Hong Wang et al.   Cell Death & Disease

MicroRNA cluster miR-17-92 regulates multiple functionally related voltage-gated potassium channels in chronic neuropathic pain

(2017) Atsushi Sakai et al.   Nature Communications

The miR-17-92 cluster as a potential biomarker for the early diagnosis of gastric cancer: evidence and literature review

(2017) Hong Li et al.   Oncotarget

Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain

(2017) Nathanael G. Lintner et al.   PLOS BIOLOGY

Microfluidics for cell-based high throughput screening platforms—A review

(2016) Guansheng Du et al.   ANALYTICA CHIMICA ACTA

Small Molecule Microarray Based Discovery of PARP14 Inhibitors

(2016) Bo Peng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modulation of the E. coli rpoH Temperature Sensor with Triptycene-Based Small Molecules

(2016) Stephanie A. Barros et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42

(2016) Jinjiang Chou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LncRNA HOXA11-AS Promotes Proliferation and Invasion of Gastric Cancer by Scaffolding the Chromatin Modification Factors PRC2, LSD1, and DNMT1

(2016) Ming Sun et al.   CANCER RESEARCH

Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors

(2016) Muhammad S. Beg et al.   INVESTIGATIONAL NEW DRUGS

Modern mass spectrometry for synthetic biology and structure-based discovery of natural products

(2016) Matthew T. Henke et al.   NATURAL PRODUCT REPORTS

Non-coding RNAs as drug targets

(2016) Masayuki Matsui et al.   NATURE REVIEWS DRUG DISCOVERY

Design of a small molecule against an oncogenic noncoding RNA

(2016) Sai Pradeep Velagapudi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic resolution mechanistic studies of ribocil: A highly selective unnatural ligand mimic of theE. coliFMN riboswitch

(2016) John A. Howe et al.   RNA Biology

Psmir: a database of potential associations between small molecules and miRNAs

(2016) Fanlin Meng et al.   Scientific Reports

Small Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression

(2015) Kenneth M. Felsenstein et al.   ACS Chemical Biology

Novel Riboswitch-Binding Flavin Analog That Protects Mice against Clostridium difficile Infection without Inhibiting Cecal Flora

(2015) Kenneth F. Blount et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

AC1MMYR2 impairs high dose paclitaxel-induced tumor metastasis by targeting miR-21/CDK5 axis

(2015) Yu Ren et al.   CANCER LETTERS

MicroRNA-34a suppresses the breast cancer stem cell-like characteristics by downregulating Notch1 pathway

(2015) Le Kang et al.   CANCER SCIENCE

High-throughput analysis of behavior for drug discovery

(2015) Vadim Alexandrov et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Long noncoding RNADANCRincreases stemness features of hepatocellular carcinoma by derepression ofCTNNB1

(2015) Sheng-xian Yuan et al.   HEPATOLOGY

Selective small-molecule inhibition of an RNA structural element

(2015) John A. Howe et al.   NATURE

SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice

(2015) James Palacino et al.   Nature Chemical Biology

Discovery of Selective Ligands for Telomeric RNA G-quadruplexes (TERRA) through 19F-NMR Based Fragment Screening

(2014) Miguel Garavís et al.   ACS Chemical Biology

Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo

(2014) Arunoday Bhan et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Identification of Biologically Active, HIV TAR RNA-Binding Small Molecules Using Small Molecule Microarrays

(2014) Joanna Sztuba-Solinska et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix

(2014) Jessica A Brown et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MALAT1 promotes the proliferation and metastasis of osteosarcoma cells by activating the PI3K/Akt pathway

(2014) Yongqiang Dong et al.   TUMOR BIOLOGY

AC1MMYR2, an Inhibitor of Dicer-Mediated Biogenesis of Oncomir miR-21, Reverses Epithelial-Mesenchymal Transition and Suppresses Tumor Growth and Progression

(2013) Z. Shi et al.   CANCER RESEARCH

A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication

(2013) Mi-Kyung Lee et al.   CHEMICAL COMMUNICATIONS

Recent discoveries and applications involving small-molecule microarrays

(2013) Jiyoung A Hong et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Antisense Transcript Long Noncoding RNA (lncRNA) HOTAIR is Transcriptionally Induced by Estradiol

(2013) Arunoday Bhan et al.   JOURNAL OF MOLECULAR BIOLOGY

Expanding the Number of ‘Druggable’ Targets: Non-Enzymes and Protein-Protein Interactions

(2012) Leah N. Makley et al.   Chemical Biology & Drug Design

STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer

(2010) Dimitrios Iliopoulos et al.   MOLECULAR CELL

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE

The widespread regulation of microRNA biogenesis, function and decay

(2010) Jacek Krol et al.   NATURE REVIEWS GENETICS

Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

(2010) M.-C. Tsai et al.   SCIENCE

Small-molecule microarrays as tools in ligand discovery

(2008) Arturo J. Vegas et al.   CHEMICAL SOCIETY REVIEWS

Two-Dimensional Combinatorial Screening Identifies Specific Aminoglycoside−RNA Internal Loop Partners

(2008) Matthew D. Disney et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The MC-Fold and MC-Sym pipeline infers RNA structure from sequence data

(2008) Marc Parisien et al.   NATURE

A small molecule enhances RNA interference and promotes microRNA processing

(2008) Ge Shan et al.   NATURE BIOTECHNOLOGY

The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning

(2008) D. N. Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA