Article
Endocrinology & Metabolism
Xiaohui Sun, Yuyan Shi, Nan Hua
Summary: In this study, HOTAIR was found to be highly expressed in patients with gastric cancer and OXA-resistant cells. Silencing HOTAIR significantly inhibited the proliferation, migration, and invasion ability of gastric cancer cells, increased apoptosis rate, and arrested cells in the G2 phase. Furthermore, HOTAIR silencing inhibited the PI3K/Akt signaling pathway and epithelial-mesenchymal transition process, leading to the inhibition of OXA resistance in gastric cancer.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Cell Biology
Chen Mi, Dan Zhang, Yarui Li, Mudan Ren, Wenhui Ma, Guifang Lu, Shuixiang He
Summary: Gastric cancer ranks among the top three leading causes of cancer-related deaths globally. The dysregulation of miR-4677-3p has been linked to the modulation of invasion and migration in various cancer cell types. This study demonstrates that miR-4677-3p is down-regulated in gastric cancer tissues and cells, and over-expression of miR-4677-3p suppresses cell proliferation, migration, and invasion by targeting the CEMIP-PI3K/AKT signaling pathway axis.
Article
Oncology
Danfang Wang, Jianhui Li, Wenhan Li
Summary: This study investigates the role of LHPP in gastric cancer (GC) and finds that LHPP acts as a tumor suppressor gene by inhibiting proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of GC cells. The underlying mechanism involves regulating the PI3K/AKT/mTOR pathway.
Article
Oncology
Guoxian Wu, Aimin Zhang, Yinglin Yang, Dongping Wu
Summary: The study revealed that high expression of circ-RNF111 in gastric cancer cells, and silencing circ-RNF111 inhibited cell growth, invasion, and glycolysis while inducing apoptosis. Circ-RNF111 positively regulated KLF12 expression through absorbing miR-876-3p.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Xiaosi Hu, Shuai Zhou, Haohao Li, Zehui Wu, Ye Wang, Lei Meng, Zhangming Chen, Zhijian Wei, Qing Pang, Aman Xu
Summary: This study found that MND1 is highly expressed in gastric cancer and is associated with resistance to the chemotherapy drug oxaliplatin. Overexpression of MND1 is linked to worse prognosis and advanced pathological characteristics in gastric cancer patients. FOXA1 regulates gastric cancer progression by inhibiting the transcription of MND1. The interaction between MND1 and TKT activates the PI3K/AKT signaling pathway, promoting gastric cancer progression.
CANCER CELL INTERNATIONAL
(2023)
Article
Genetics & Heredity
Qian Zhang, Jun Dan, Shuang Meng, Yingjie Li, Jing Li
Summary: This study investigated the role of Toll-like receptor 4 (TLR4) in autophagy and proliferation in gastric cancer (GC) cells. The levels of TLR4 were determined in different stages of GC cells/tissues using RT-qPCR and WB, along with the levels of autophagy-related proteins (ARPs) and the underlying signaling mechanism. Proliferation was assessed using the CCK-8 assay. The results revealed that modulation of the PI3K/AKT/mTOR pathway was induced by the overexpression and knockdown of TLR4, leading to inhibition/induction of autophagy, and TLR4 played a vital role in GC progression.
Review
Oncology
Huayi Li, Lorenzo Prever, Emilio Hirsch, Federico Gulluni
Summary: The PI3K signaling pathway is crucial in breast cancer and inhibitors targeting this pathway show promising activity, but resistance and adverse reactions limit their efficacy. Combination therapies and identifying suitable patient subpopulations are needed to enhance therapeutic benefit.
Article
Pharmacology & Pharmacy
Yunhao Ma, Hao Xu, Zhongkun Zhou, Yanan Tian, Kangjia Du, Hao Zhang, Xinrong Jiang, Juan Lu, Yuqing Niu, Lixue Tu, Huanxiang Liu, Hongmei Zhu, Peng Chen, Yingqian Liu
Summary: In the treatment of gastric cancer, natural products modified by structural modification can be a promising strategy for finding anti-gastric cancer drugs. In this study, a novel derivative CFNC was synthesized and found to have potential anti-gastric cancer effects by regulating the PI3K/AKT/mTOR signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Anatomy & Morphology
Wenying Zhang, Qiongwei Wu, Yu Liu, Xujie Wang, Chengbin Ma, Weipei Zhu
Summary: This study reveals the mechanism of HOTAIR involvement in cervical cancer, showing that it promotes tumor cell migration, proliferation, and chemoresistance through the miR-29b/PTEN/PI3K axis.
CELLS TISSUES ORGANS
(2022)
Review
Pharmacology & Pharmacy
Ayda Baghery Saghchy Khorasani, Atieh Pourbagheri-Sigaroodi, Ali Pirsalehi, Ava Safaroghli-azar, Mohammad Reza Zali, Davood Bashash
Summary: Genetic and epigenetic alterations have long been the focus of cancer pathogenesis research, with dysregulated genes and protein products potentially affecting cancer cell growth through signaling cascades regulating cell survival and metabolism. The activation of the phosphatidylinositol-3-kinase (PI3K) axis in about one-third of human cancers, including gastric cancer, plays a significant role in the development of malignancies. This indicates the potential importance of targeting this axis in therapeutic strategies for such cancers.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Plant Sciences
Dan Qiao, Jian Xing, Yunxiao Duan, Shiyu Wang, Guangyuan Yao, Shengjun Zhang, Jingchun Jin, Zhenhua Lin, Liyan Chen, Yingshi Piao
Summary: Baicalein inhibits the progression of gastric cancer by regulating the miR-7/FAK/AKT signaling pathway, leading to the suppression of proliferation, metastasis, and angiogenesis in gastric cancer cells.
Article
Biochemistry & Molecular Biology
Qianxiu Li, Zhongxiu Zhu, Hanyu Zhang, Xu Wu, Huan Yang, Xiaobing Li, Wanping Li, Yueshui Zhao, Fukuan Du, Yu Chen, Jing Shen, Zhangang Xiao, Meijuan Chen, Fang Wang, Li Gu, Yuhong Sun, Lan Lu, Yuliang Jia, Mingxing Li
Summary: This study found that long non-coding RNA (lncRNA) RP11-93B14.5 facilitates tumor progression and regulates the PI3K/AKT signaling pathway in gastric cancer (GC). Bioinformatics analysis revealed that RP11-93B14.5 was upregulated in GC tissues. Knockdown of RP11-93B14.5 decreased cell viability and colony formation, and altered cell cycle distribution. RNA-seq analysis indicated that RP11-93B14.5 may modulate expression of S100A2 and TIMP2 genes.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Biology
Ning Ding, Yu Zhang, Mengna Huang, Jianfeng Liu, Chonglong Wang, Chun Zhang, Jinkang Cao, Qin Zhang, Li Jiang
Summary: This study identified circ-CREBBP as a biomarker and therapeutic target for male reproductive diseases. It promotes sperm motility and inhibits apoptosis by sponging miR-10384 and miR-143-3p.
COMMUNICATIONS BIOLOGY
(2022)
Article
Oncology
Zhendan Zhao, Zhiling Wang, Pengling Wang, Shujie Liu, Yingwei Li, Xingsheng Yang
Summary: The study identified EPDR1 as a tumor-suppressor gene negatively regulated by miR-429 in EOC development, inhibiting proliferation, migration, and invasion of cancer cells through the PI3K/AKT pathway. The miR-429/EPDR1 axis may offer novel therapeutic targets for personalized treatment of EOC patients in the future.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mahtab Yadollahi-Farsani, Zeinab Amini-Farsani, Fatemeh Moayedi, Niusha Khazaei, Hajar Yaghoobi
Summary: This study revealed that miR-548k is significantly overexpressed in breast cancer tissues and promotes cell proliferation and inhibits apoptosis by suppressing the expression of the PTEN gene through the PI3K/Akt pathway. It provides insights into the biological role and potential mechanism of miR-548k in breast cancer.