Journal
MOLECULES
Volume 23, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/molecules23020233
Keywords
fragment-based drug discovery; nuclearmagnetic resonance; fragment based virtual screening
Funding
- U.S.-Israeli Binational Science Foundation [2016142]
Ask authors/readers for more resources
Fragment-based drug discovery (FBDD) using NMR has become a central approach over the last twenty years for development of small molecule inhibitors against biological macromolecules, to control a variety of cellular processes. Yet, several considerations should be taken into account for obtaining a therapeutically relevant agent. In this review, we aim to list the considerations that make NMR fragment screening a successful process for yielding potent inhibitors. Factors that may govern the competence of NMR in fragment based drug discovery are discussed, as well as later steps that involve optimization of hits obtained by NMR-FBDD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available