Review
Oncology
Jiaqi Liu, Chi Tim Leung, Luyun Liang, Yuqin Wang, Jian Chen, Keng Po Lai, William Ka Fai Tse
Summary: This review summarizes the current findings of DUBs in the most common cancers worldwide, including liver, breast, prostate, colorectal, pancreatic, and lung cancers, with regards to their roles in proliferation, metastasis, and apoptosis. The review provides an updated overview of the current findings and can serve as a quick guide for researchers in identifying target DUBs in cancer.
Review
Immunology
Yating Xu, Xiao Yu, Wenzhi Guo, Yuting He
Summary: m6A modification plays an important role in various biological processes and also affects the metabolic processes of non-coding genes. However, the specific interaction between m6A and ncRNAs in gastrointestinal cancers is still not fully discussed. In this study, we analyzed and summarized how ncRNAs affect the regulators of m6A and how the expression of ncRNAs is altered via m6A in gastrointestinal cancers. Our findings reveal more possibilities of using ncRNAs for diagnosis and treatment in terms of epigenetic modification.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Katarzyna Ratajczak, Sylwia Borska
Summary: Cancer diseases pose a major challenge in clinical medicine globally, with drug resistance being a significant issue. Natural compounds, particularly polyphenols, are believed to have pleiotropic effects on cells and toxic effects on cancer cells, showing promise as a new approach to cancer treatment. Studies on the effectiveness of resveratrol in treating cancer, including reversing multidrug resistance, are ongoing and may provide valuable insights for future in vivo and clinical studies.
Article
Multidisciplinary Sciences
L. E. Anselmino, M. Baglioni, F. Malizia, N. Cesatti Laluce, C. Borini Etichetti, V. L. Martinez Marignac, V Rozados, O. G. Scharovsky, J. Girardini, M. J. Rico, M. Menacho Marquez
Summary: Drug repositioning accelerates drug development process, finding effective drugs with reduced side effects and lower costs. Combining metformin and propranolol shows potential as adjuvant therapy for both CRC and TNBC, as well as effective alternative for chemo-resistant CRC.
SCIENTIFIC REPORTS
(2021)
Review
Food Science & Technology
Si-Xia Wu, Ruo-Gu Xiong, Si-Yu Huang, Dan-Dan Zhou, Adila Saimaiti, Cai-Ning Zhao, Ao Shang, Yun-Jian Zhang, Ren-You Gan, Hua-Bin Li
Summary: Cancer is a severe public health problem, and resveratrol, a natural compound with various bioactivities, has been shown to have preventive and therapeutic effects on different types of cancers. This review summarizes the effects and mechanisms of resveratrol in cancer prevention and treatment, providing guidance for the development of functional food, dietary supplements, or auxiliary agents for cancer management.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
George Denis Alexandru Popescu, Cristian Scheau, Ioana Anca Badarau, Mihai-Daniel Dumitrache, Ana Caruntu, Andreea-Elena Scheau, Daniel Octavian Costache, Raluca Simona Costache, Carolina Constantin, Monica Neagu, Constantin Caruntu
Summary: Gastrointestinal (GI) cancers are highly prevalent diseases with complicated molecular mechanisms. The treatment of these cancers is challenging due to chemoresistance and adverse reactions, leading to a growing focus on new therapies such as phytochemicals, with capsaicin being a subject of intense research.
Review
Oncology
Kai Zimmer, Florian Kocher, Alberto Puccini, Andreas Seeber
Summary: Mutations in the DDR genes BRCA1 and BRCA2 were originally identified as major susceptibility genes in breast and ovarian cancers, and with the advancement of cost-effective gene sequencing methods, these mutations have been detected in various cancers. The approval of PARP inhibitors for BRCA-mutated cancers has increased the therapeutic implications of BRCA mutations, while other genes in the DDR pathway like ATM, ATR, and CHK1 have emerged as potential new treatment targets currently under clinical investigation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Mei-Zhu Hong, Jing-Mao Li, Zhi-Jian Chen, Xiao-Yun Lin, Jin-Shui Pan, Li-Li Gong
Summary: This study analyzed the relationship between the burden of gastrointestinal tract cancers and socioeconomic status, revealing that high-income countries should pay attention to screening for colon and rectum cancer and pancreatic cancer, while low-income countries should focus on screening for stomach cancer and esophageal cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Chemistry, Medicinal
Belal Almajali, Hamid Ali Nagi Al-Jamal, Wan Rohani Wan Taib, Imilia Ismail, Muhammad Farid Johan, Abd Almonem Doolaanea, Wisam Nabeel Ibrahim
Summary: Natural product thymoquinone (TQ) from Nigella sativa has shown promising anticancer activities through inhibiting cell proliferation, migration, and invasion in various human cancers. Its efficacy in inducing apoptosis and mechanisms on different cancer types are still not fully understood, but there is ongoing research on its potential as a future anticancer therapy nominee, especially in combination with other anticancer agents using nanotechnology.
Review
Oncology
Azadeh Tabari, Shin Mei Chan, Omar Mustafa Fathy Omar, Shams I. I. Iqbal, Michael S. S. Gee, Dania Daye
Summary: Worldwide, about 25% of global cancer cases are gastrointestinal (GI) malignancies. However, many GI malignancies lack effective biomarkers for staging and prognosis. Radiomics, using high-throughput data to extract features from medical images, and machine learning, analyzing and predicting patterns from sample data, offer potential for personalized precision medicine. This review explores the use of radiomics and machine learning in the diagnosis, staging, prognosis, and treatment response of different GI cancers, and discusses the challenges and future opportunities.
Review
Oncology
Mei-Mei Li, Jun Yuan, Xin-Yuan Guan, Ning-Fang Ma, Ming Liu
Summary: Human gastrointestinal malignancies are highly heterogeneous cancers defined by molecular subtypes, with cancer stem cells playing a significant role in tumor heterogeneity. Abnormally active embryonic genes and developmental signaling pathways may act as drivers in certain tumor subtypes.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Review
Oncology
Vaibhav Wadhwa, Nicole Patel, Dheera Grover, Faisal S. S. Ali, Nirav Thosani
Summary: Cancer in the gastrointestinal tract is a major global health issue, and early diagnosis and prompt management are crucial in preventing morbidity and mortality. Endoscopy has become the cornerstone in the diagnosis and management of gastrointestinal tract cancers.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Review
Oncology
Artur Rebelo, Johannes Klose, Jorg Kleeff, Ulrich Ronellenfitsch
Summary: This article discusses the importance of randomised trials comparing surgery with non-surgical therapies for specific scenarios in the treatment of gastrointestinal cancers. The authors performed a selective review of these trials, highlighting their differences, advantages, and limitations.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Daryl Ramai, Joseph Heaton, Michele Ghidini, Saurabh Chandan, Mohamed Barakat, Banreet Dhindsa, Amaninder Dhaliwal, Antonio Facciorusso
Summary: Patients with major gastrointestinal cancers are at increased risk for cardiac-specific mortality compared with noncardiac mortality. The use of chemotherapy, radiation, or a combination of both for treatment is associated with higher cardiac mortality in these patients.
Review
Pharmacology & Pharmacy
Xiaoxia Yang, Hua Cui, Lin Lin, Ganting Zhao
Summary: Due to limitations of conventional therapy for various cancers, including gastrointestinal cancers, and the decrease in patient survival rate, there is an urgent need for new effective therapeutic approaches without the adverse effects of traditional agents. Antimicrobial peptides (AMPs), known for their role in innate immunity, have attracted much attention. Besides their antimicrobial activity, AMPs exhibit strong anticancer potential against various malignancies. They specifically target tumor cells and have selective toxicity, sparing normal cells. This article aims to comprehensively overview the current knowledge on using AMPs as novel therapeutic agents for gastrointestinal cancer.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Olabisi Oluwabukola Coker, Angkana Chaiprasert, Chumpol Ngamphiw, Sissades Tongsima, Sanjib Mani Regmi, Taane G. Clark, Rick Twee Hee Ong, Yik-Ying Teo, Therdsak Prammananan, Prasit Palittapongarnpim
Article
Gastroenterology & Hepatology
Olabisi Oluwabukola Coker, Zhenwei Dai, Yongzhan Nie, Guijun Zhao, Lei Cao, Geicho Nakatsu, William K. K. Wu, Sunny Hei Wong, Zigui Chen, Joseph J. Y. Sung, Jun Yu
Article
Gastroenterology & Hepatology
Geicho Nakatsu, Haokui Zhou, William Ka Kei Wu, Sunny Hei Wong, Olabisi Oluwabukola Coker, Zhenwei Dai, Xiangchun Li, Chun-Ho Szeto, Naoki Sugimura, Thomas Yuen-Tung Lam, Allen Chi-Shing Yu, Xiansong Wang, Zigui Chen, Martin Chi-Sang Wong, Siew Chien Ng, Matthew Tak Vai Chan, Paul Kay Sheung Chan, Francis Ka Leung Chan, Joseph Jao-Yiu Sung, Jun Yu
Article
Microbiology
Zhenwei Dai, Olabisi Oluwabukola Coker, Geicho Nakatsu, William K. K. Wu, Liuyang Zhao, Zigui Chen, Francis K. L. Chan, Karsten Kristiansen, Joseph J. Y. Sung, Sunny Hei Wong, Jun Yu
Article
Oncology
X. Wang, X. Li, L. Zhang, S. H. Wong, M. H. T. Wang, G. Tse, R. Z. W. Dai, G. Nakatsu, O. O. Coker, Z. Chen, H. Ko, J. Y. K. Chan, T. Liu, C. H. K. Cheng, A. S. L. Cheng, K. F. To, D. Plewczynski, J. J. Y. Sung, J. Yu, T. Gin, M. T. V. Chan, W. K. K. Wu
ANNALS OF ONCOLOGY
(2018)
Article
Microbiology
Olabisi Oluwabukola Coker, Saradee Warit, Kamolchanok Rukseree, Pijug Summpunn, Therdsak Prammananan, Prasit Palittapongarnpim
Article
Gastroenterology & Hepatology
Olabisi Oluwabukola Coker, Geicho Nakatsu, Rudin Zhenwei Dai, William Ka Kei Wu, Sunny Hei Wong, Siew Chien Ng, Francis Ka Leung Chan, Joseph Jao Yiu Sung, Jun Yu
Article
Microbiology
Xiaohang Long, Chi Chun Wong, Li Tong, Eagle S. H. Chu, Chun Ho Szeto, Minne Y. Y. Go, Olabisi Oluwabukola Coker, Anthony W. H. Chan, Francis K. L. Chan, Joseph J. Y. Sung, Jun Yu
NATURE MICROBIOLOGY
(2019)
Article
Infectious Diseases
Sanjib Mani Regmi, Olabisi Oluwabukola Coker, Supasak Kulawonganunchai, Sissades Tongsima, Therdsak Prammananan, Wasna Viratyosin, Iyarit Thaipisuttikul, Angkana Chaiprasert
INTERNATIONAL JOURNAL OF MYCOBACTERIOLOGY
(2015)