Metabolic adaptation to the chronic loss of Ca2+ signaling induced by KO of IP3 receptors or the mitochondrial Ca2+ uniporter

MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer

(2020) Jessica C. Casciano et al.   BRITISH JOURNAL OF CANCER

An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance

(2020) Anupam Patgiri et al.   NATURE BIOTECHNOLOGY

Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells

(2020) Lili Yue et al.   Cells

The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice

(2020) Eleni Georgiadou et al.   DIABETOLOGIA

The debate continues – What is the role of MCU and mitochondrial calcium uptake in the heart?

(2020) Joanne F. Garbincius et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inositol 1,4,5-trisphosphate receptors are essential for fetal-maternal connection and embryo viability

(2020) Feili Yang et al.   PLoS Genetics

Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum–to–mitochondria Ca2+ transfer for survival

(2020) Cesar Cardenas et al.   Science Signaling

Knockout of the Mitochondrial Calcium Uniporter Strongly Suppresses Stimulus-Metabolism Coupling in Pancreatic Acinar Cells but Does Not Reduce Severity of Experimental Acute Pancreatitis

(2020) Michael Chvanov et al.   Cells

Mitochondrial Calcium Uniporter (MCU) deficiency reveals an alternate path for Ca2+ uptake in photoreceptor mitochondria

(2020) Celia M. Bisbach et al.   Scientific Reports

Blockade of MCU-Mediated Ca2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation

(2019) Dhanendra Tomar et al.   Cell Reports

Cardiac-specific deficiency of the mitochondrial calcium uniporter augments fatty acid oxidation and functional reserve

(2019) Tariq R. Altamimi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation

(2019) Olha M. Koval et al.   Science Signaling

Exploring the In Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics

(2019) Daniel Flicker et al.   Cell Reports

High extracellular lactate causes reductive carboxylation in breast tissue cell lines grown under normoxic conditions

(2019) Arthur Nathan Brodsky et al.   PLoS One

Mitochondrial calcium uniporter regulates PGC-1α expression to mediate metabolic reprogramming in pulmonary fibrosis

(2019) Linlin Gu et al.   Redox Biology

A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering

(2019) Tsz-Leung To et al.   CELL

Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation

(2019) Alyssa A. Lombardi et al.   Nature Communications

Inhibitors of the mitochondrial calcium uniporter for the treatment of disease

(2019) Joshua J. Woods et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Metabolomics and Isotope Tracing

(2018) Cholsoon Jang et al.   CELL

Calcium and regulation of the mitochondrial permeability transition

(2018) Valentina Giorgio et al.   CELL CALCIUM

The regulation of autophagy by calcium signals: Do we have a consensus?

(2018) Martin D. Bootman et al.   CELL CALCIUM

TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca 2+ Transfer

(2018) Riccardo Filadi et al.   CURRENT BIOLOGY

Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism

(2018) Gary Yellen   JOURNAL OF CELL BIOLOGY

NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction

(2018) Edoardo Gaude et al.   MOLECULAR CELL

Nicotinamide adenine dinucleotide is transported into mammalian mitochondria

(2018) Antonio Davila et al.   eLife

Loss of mitochondrial calcium uniporter rewires skeletal muscle metabolism and substrate preference

(2018) Gaia Gherardi et al.   CELL DEATH AND DIFFERENTIATION

Deletion of IP3R1 by Pdgfrb-Cre in mice results in intestinal pseudo-obstruction and lethality

(2018) Hong Wang et al.   JOURNAL OF GASTROENTEROLOGY

Aberrant IP3 receptor activities revealed by comprehensive analysis of pathological mutations causing spinocerebellar ataxia 29

(2018) Hideaki Ando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monitoring and Measuring Autophagy

(2017) Saori R. Yoshii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Loss of IP3Receptor–Mediated Ca2+Release in Mouse B Cells Results in Abnormal B Cell Development and Function

(2017) Huayuan Tang et al.   JOURNAL OF IMMUNOLOGY

Simplified CRISPR tools for efficient genome editing and streamlined protocols for their delivery into mammalian cells and mouse zygotes

(2017) Ashley M. Jacobi et al.   METHODS

Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening

(2017) Daniela M. Arduino et al.   MOLECULAR CELL

Intracellular Ca 2+ Sensing: Its Role in Calcium Homeostasis and Signaling

(2017) Rafaela Bagur et al.   MOLECULAR CELL

MCU-dependent mitochondrial Ca2+ inhibits NAD+/SIRT3/SOD2 pathway to promote ROS production and metastasis of HCC cells

(2017) T Ren et al.   ONCOGENE

IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin–NFATc3–Etv2 pathway

(2017) Yi-Jie Wang et al.   Journal of Molecular Cell Biology

IP3 Receptor-Mediated Calcium Signaling and Its Role in Autophagy in Cancer

(2017) Elzbieta Kania et al.   Frontiers in Oncology

Structure, Activity Regulation, and Role of the Mitochondrial Calcium Uniporter in Health and Disease

(2017) Cristina Mammucari et al.   Frontiers in Oncology

A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation

(2016) Jason D. Arroyo et al.   Cell Metabolism

Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development

(2016) Keiko Uchida et al.   DEVELOPMENTAL BIOLOGY

Global ablation of the mitochondrial calcium uniporter increases glycolysis in cortical neurons subjected to energetic stressors

(2016) Matthew Nichols et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+release

(2016) Kamil J. Alzayady et al.   Science Signaling

Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria

(2016) César Cárdenas et al.   Cell Reports

Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+release

(2016) Kamil J. Alzayady et al.   Science Signaling

The roles of IP3 receptor in energy metabolic pathways and reactive oxygen species homeostasis revealed by metabolomic and biochemical studies

(2015) He Wen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter

(2015) Kira M. Holmström et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Tracing the Evolutionary History of Inositol, 1, 4, 5-Trisphosphate Receptor: Insights from Analyses ofCapsaspora owczarzakiCa2+Release Channel Orthologs

(2015) Kamil J. Alzayady et al.   MOLECULAR BIOLOGY AND EVOLUTION

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart

(2015) Tyler P. Rasmussen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

(2015) Timothy S. Luongo et al.   Cell Reports

The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart

(2015) Jennifer Q. Kwong et al.   Cell Reports

Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins

(2014) S. Kim et al.   GENOME RESEARCH

Mitochondrial Calcium Uniporter Activity Is Dispensable for MDA-MB-231 Breast Carcinoma Cell Survival

(2014) Duane D. Hall et al.   PLoS One

Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia

(2014) Kunfu Ouyang et al.   Nature Communications

Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects

(2014) Andrew R. Mullen et al.   Cell Reports

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter

(2013) Xin Pan et al.   NATURE CELL BIOLOGY

EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex

(2013) Y. Sancak et al.   SCIENCE

Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells

(2012) Fabian V. Filipp et al.   Pigment Cell & Melanoma Research

A Multi-Omics Analysis of Recombinant Protein Production in Hek293 Cells

(2012) Stefanie Dietmair et al.   PLoS One

The Mitochondrial Ca2+ Uniporter MCU Is Essential for Glucose-Induced ATP Increases in Pancreatic β-Cells

(2012) Andrei I. Tarasov et al.   PLoS One

Evolutionary Diversity of the Mitochondrial Calcium Uniporter

(2012) A. G. Bick et al.   SCIENCE

Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review)

(2012) JIE ZHENG   Oncology Letters

Role of IP3 receptor in development

(2011) Katsuhiko Mikoshiba   CELL CALCIUM

Inositol 1,4,5-trisphosphate receptors are essential for the development of the second heart field

(2011) Maki Nakazawa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Galactose Enhances Oxidative Metabolism and Reveals Mitochondrial Dysfunction in Human Primary Muscle Cells

(2011) Céline Aguer et al.   PLoS One

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Expanded Palette of Genetically Encoded Ca2+ Indicators

(2011) Y. Zhao et al.   SCIENCE

Unraveling the metabolism of HEK-293 cells using lactate isotopomer analysis

(2010) Olivier Henry et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

Role of Inositol Trisphosphate Receptors in Autophagy in DT40 Cells

(2010) M. Tariq Khan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene Knock-Outs of Inositol 1,4,5-Trisphosphate Receptors Types 1 and 2 Result in Perturbation of Cardiogenesis

(2010) Keiko Uchida et al.   PLoS One

Quiescent Fibroblasts Exhibit High Metabolic Activity

(2010) Johanna M. S. Lemons et al.   PLOS BIOLOGY

An enzymatic fluorimetric assay for glucose-6-phosphate: Application in an in vitro Warburg-like effect

(2009) Aiping Zhu et al.   ANALYTICAL BIOCHEMISTRY

A sensitive fluorimetric assay for pyruvate

(2009) Aiping Zhu et al.   ANALYTICAL BIOCHEMISTRY

Regulation of mitochondrial dehydrogenases by calcium ions

(2009) Richard M. Denton   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

IP3receptors: some lessons from DT40 cells

(2009) Colin W. Taylor et al.   IMMUNOLOGICAL REVIEWS