An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance

Metabolic Responses to Reductive Stress

(2019) Wusheng Xiao et al.   ANTIOXIDANTS & REDOX SIGNALING

mTOR inhibitors may benefit kidney transplant recipients with mitochondrial diseases

(2018) Simon C. Johnson et al.   KIDNEY INTERNATIONAL

Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin

(2016) Dan Y. Gui et al.   Cell Metabolism

A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation

(2016) Jason D. Arroyo et al.   Cell Metabolism

Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio

(2016) D. V. Titov et al.   SCIENCE

A Metabolic Signature of Mitochondrial Dysfunction Revealed through a Monogenic Form of Leigh Syndrome

(2015) Julie Thompson Legault et al.   Cell Reports

The Extracellular Redox State Modulates Mitochondrial Function, Gluconeogenesis, and Glycogen Synthesis in Murine Hepatocytes

(2015) Laura Nocito et al.   PLoS One

Efficacy of pyruvate therapy in patients with mitochondrial disease: A semi-quantitative clinical evaluation study

(2014) Tatsuya Fujii et al.   MOLECULAR GENETICS AND METABOLISM

Prolonged Prophylactic Protection from Botulism with a Single Adenovirus Treatment Promoting Serum Expression of a VHH-Based Antitoxin Protein

(2014) Jean Mukherjee et al.   PLoS One

On the Dynamics of the Adenylate Energy System: Homeorhesis vs Homeostasis

(2014) Ildefonso M. De la Fuente et al.   PLoS One

A complex V ATP5A1 defect causes fatal neonatal mitochondrial encephalopathy

(2013) An I. Jonckheere et al.   BRAIN

Comparative study of three lactate oxidases from Aerococcus viridans for biosensing applications

(2013) Irene Taurino et al.   ELECTROCHIMICA ACTA

Fusing catalase to an alkane-producing enzyme maintains enzymatic activity by converting the inhibitory byproduct H2O2 to the cosubstrate O2

(2013) C. Andre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial disorders as windows into an ancient organelle

(2012) Scott B. Vafai et al.   NATURE

Pyruvate therapy for mitochondrial DNA depletion syndrome

(2011) Keiko Saito et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Imaging Cytosolic NADH-NAD+ Redox State with a Genetically Encoded Fluorescent Biosensor

(2011) Yin Pun Hung et al.   Cell Metabolism

A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells

(2010) O. Shaham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA