Interference on Cytosolic DNA Activation Attenuates Sepsis Severity: Experiments on Cyclic GMP–AMP Synthase (cGAS) Deficient Mice

Prominent Indomethacin-Induced Enteropathy in Fcgriib Defi-cient lupus Mice: An Impact of Macrophage Responses and Immune Deposition in Gut

(2021) Thansita Bhunyakarnjanarat et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lipopolysaccharide-Enhanced Responses against Aryl Hydrocarbon Receptor in FcgRIIb-Deficient Macrophages, a Profound Impact of an Environmental Toxin on a Lupus-Like Mouse Model

(2021) Kanyarat Udompornpitak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Candida Administration in Bilateral Nephrectomy Mice Elevates Serum (1→3)-β-D-glucan That Enhances Systemic Inflammation Through Energy Augmentation in Macrophages

(2021) Jiraphorn Issara-Amphorn et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Perillaldehyde Inhibition of cGAS Reduces dsDNA-Induced Interferon Response

(2021) Lei Chu et al.   Frontiers in Immunology

cGAS knockdown promotes microglial M2 polarization to alleviate neuroinflammation by inhibiting cGAS-STING signaling pathway in cerebral ischemic stroke

(2021) Guo-Liang Jiang et al.   BRAIN RESEARCH BULLETIN

Increased susceptibility to dextran sulfate-induced mucositis of iron-overload β-thalassemia mice, another endogenous cause of septicemia in thalassemia

(2021) Peerapat Visitchanakun et al.   CLINICAL SCIENCE

BAM15, a Mitochondrial Uncoupling Agent, Attenuates Inflammation in the LPS Injection Mouse Model: An Adjunctive Anti-Inflammation on Macrophages and Hepatocytes

(2021) Cong Phi Dang et al.   Journal of Innate Immunity

STING1 in sepsis: Mechanisms, functions, and implications

(2021) Ruo-Xi Zhang et al.   Chinese Journal of Traumatology

Targeting immunometabolism as an anti-inflammatory strategy

(2020) Eva M. Pålsson-McDermott et al.   CELL RESEARCH

Rapid diagnosis and comprehensive bacteria profiling of sepsis based on cell-free DNA

(2020) Pei Chen et al.   Journal of Translational Medicine

The complete blood count to diagnose septic shock

(2020) Joshua David Farkas   Journal of Thoracic Disease

Gut leakage enhances sepsis susceptibility in iron-overloaded β-thalassemia mice through macrophage hyperinflammatory responses

(2020) Peerapat Visitchanakun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Glycolysis – a key player in the inflammatory response

(2020) Gonzalo Soto‐Heredero et al.   FEBS Journal

mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

(2020) Long Shuang Huang et al.   IMMUNITY

Molecular mechanisms and cellular functions of cGAS–STING signalling

(2020) Karl-Peter Hopfner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Increased Plasma Levels of Mitochondrial DNA and Normal Inflammasome Gene Expression in Monocytes Characterize Patients With Septic Shock Due to Multidrug Resistant Bacteria

(2020) Stefano Busani et al.   Frontiers in Immunology

AMPK, Mitochondrial Function, and Cardiovascular Disease

(2020) Shengnan Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Over-expression of miR-223 induces M2 macrophage through glycolysis alteration and attenuates LPS-induced sepsis mouse model, the cell-based therapy in sepsis

(2020) Cong Phi Dang et al.   PLoS One

Dysregulation of Lipid Metabolism in Macrophages Is Responsible for Severe Endotoxin Tolerance in FcgRIIB-Deficient Lupus Mice

(2020) Thiranut Jaroonwitchawan et al.   Frontiers in Immunology

Macrophages and the maintenance of homeostasis

(2020) David M. Mosser et al.   Cellular & Molecular Immunology

The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development

(2020) Zhenxing Cheng et al.   MEDIATORS OF INFLAMMATION

Identification of cGAS as an innate immune sensor of extracellular bacterium Pseudomonas aeruginosa

(2020) Chuan-min Zhou et al.   iScience

STING-mediated intestinal barrier dysfunction contributes to lethal sepsis

(2019) Qiongyuan Hu et al.   EBioMedicine

Gut Leakage of Fungal-Derived Inflammatory Mediators: Part of a Gut-Liver-Kidney Axis in Bacterial Sepsis

(2019) Panomwat Amornphimoltham et al.   DIGESTIVE DISEASES AND SCIENCES

The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism

(2019) Juli Bai et al.   DIABETES

Plasma miR-370-3p As a Biomarker of Sepsis-Associated Encephalopathy, The Transcriptomic Profiling Analysis of Microrna-Arrays From Mouse Brains

(2019) Peerapat Visitchanakun et al.   SHOCK

STING signaling and host defense against microbial infection

(2019) Jeonghyun Ahn et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Mesenchymal stromal cells and macrophages in sepsis: new insights

(2018) Maya E. Kotas et al.   EUROPEAN RESPIRATORY JOURNAL

STING Signaling Promotes Inflammation in Experimental Acute Pancreatitis

(2018) Qinglan Zhao et al.   GASTROENTEROLOGY

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathogen- and Danger-Associated Molecular Patterns and the Cytokine Response in Sepsis

(2018) Arezoo Rajaee et al.   Surgical Infections

Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts

(2018) Daniel Torralba et al.   Nature Communications

The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires’ disease in humans

(2018) Juan S. Ruiz-Moreno et al.   PLoS Pathogens

Lipopolysaccharide-Induced Dephosphorylation of AMPK-Activated Protein Kinase Potentiates Inflammatory Injury via Repression of ULK1-Dependent Autophagy

(2018) Kerui Fan et al.   Frontiers in Immunology

Gold nanoparticles attenuates bacterial sepsis in cecal ligation and puncture mouse model through the induction of M2 macrophage polarization

(2018) Sujittra Taratummarat et al.   BMC MICROBIOLOGY

STING and TRIF Contribute to Mouse Sepsis, Depending on Severity of the Disease Model

(2017) Erica L. Heipertz et al.   SHOCK

Evolutionary Origins of cGAS-STING Signaling

(2017) Shally R. Margolis et al.   TRENDS IN IMMUNOLOGY

Comprehensive detection and identification of bacterial DNA in the blood of patients with sepsis and healthy volunteers using next-generation sequencing method - the observation of DNAemia

(2016) T. Gosiewski et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The role of cGAS in innate immunity and beyond

(2016) Andrea Ablasser et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Plasma Mitochondrial DNA—a Novel DAMP in Pediatric Sepsis

(2016) Valentina Di Caro et al.   SHOCK

Plasma Nuclear and Mitochondrial DNA Levels, and Markers of Inflammation, Shock, and Organ Damage in Patients with Septic Shock

(2016) Kim Timmermans et al.   SHOCK

Gastrointestinal Leakage Detected by Serum (1→3)-β-D-Glucan in Mouse Models and a Pilot Study in Patients with Sepsis

(2016) Asada Leelahavanichkul et al.   SHOCK

DNA sensor cGAS-mediated immune recognition

(2016) Pengyan Xia et al.   Protein & Cell

Sepsis and septic shock

(2016) Richard S. Hotchkiss et al.   Nature Reviews Disease Primers

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

(2015) Robert O. Watson et al.   Cell Host & Microbe

Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria

(2015) Yunhao Tan et al.   IMMUNITY

Origin of Circulating Free DNA in Sepsis: Analysis of the CLP Mouse Model

(2015) Shigeto Hamaguchi et al.   MEDIATORS OF INFLAMMATION

Immobilized Immune Complexes Induce Neutrophil Extracellular Trap Release by Human Neutrophil Granulocytes via FcγRIIIB and Mac-1

(2014) Martina Behnen et al.   JOURNAL OF IMMUNOLOGY

Endocytosis-free DNA sensing by cell surface TLR9 in neutrophils: Rapid defense with autoimmune risks

(2013) Kensuke Miyake et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Human Adrenomedullin and Its Binding Protein Attenuate Organ Injury and Reduce Mortality After Hepatic Ischemia-Reperfusion

(2009) Juntao Yang et al.   ANNALS OF SURGERY

Cell death during sepsis: integration of disintegration in the inflammatory response to overwhelming infection

(2009) Fabiano Pinheiro da Silva et al.   APOPTOSIS

Animal models of sepsis and sepsis-induced kidney injury

(2009) Kent Doi et al.   JOURNAL OF CLINICAL INVESTIGATION