VISTA expression by microglia decreases during inflammation and is differentially regulated in CNS diseases

Neurological adverse events associated with immune checkpoint inhibitors: Review of the literature

(2017) S. Cuzzubbo et al.   EUROPEAN JOURNAL OF CANCER

Systemic immune-checkpoint blockade with anti-PD1 antibodies does not alter cerebral amyloid-β burden in several amyloid transgenic mouse models

(2017) Martine Latta-Mahieu et al.   GLIA

Dicer Deficiency Differentially Impacts Microglia of the Developing and Adult Brain

(2017) Diana Varol et al.   IMMUNITY

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

(2017) Thais F Galatro et al.   NATURE NEUROSCIENCE

Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives

(2017) Lidia M. Yshii et al.   Nature Reviews Neurology

VISTA Deficiency Accelerates the Development of Fatal Murine Lupus Nephritis

(2017) Sabrina Ceeraz et al.   Arthritis & Rheumatology

Effects of Cdh23 single nucleotide substitutions on age-related hearing loss in C57BL/6 and 129S1/Sv mice and comparisons with congenic strains

(2017) Kenneth R. Johnson et al.   Scientific Reports

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

(2016) W. P. Vermeij et al.   NATURE

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

(2016) Kuti Baruch et al.   NATURE MEDICINE

Microglial brain region−dependent diversity and selective regional sensitivities to aging

(2016) Kathleen Grabert et al.   NATURE NEUROSCIENCE

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration

(2016) Melissa A Lopes Pinheiro et al.   eLife

Long-lasting pro-inflammatory suppression of microglia by LPS-preconditioning is mediated by RelB-dependent epigenetic silencing

(2015) W. Schaafsma et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammasome-Induced IL-1  Secretion in Microglia Is Characterized by Delayed Kinetics and Is Only Partially Dependent on Inflammatory Caspases

(2015) S. M. Burm et al.   JOURNAL OF NEUROSCIENCE

Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53

(2015) K. W. Yoon et al.   SCIENCE

Sublime Microglia: Expanding Roles for the Guardians of the CNS

(2014) Michael W. Salter et al.   CELL

Glial cells suppress postencephalitic CD8+T lymphocytes through PD-L1

(2014) Scott J. Schachtele et al.   GLIA

In acute experimental autoimmune encephalomyelitis, infiltrating macrophages are immune activated, whereas microglia remain immune suppressed

(2014) I. D. Vainchtein et al.   GLIA

Coinhibitory receptor PD-1H preferentially suppresses CD4+ T cell–mediated immunity

(2014) Dallas B. Flies et al.   JOURNAL OF CLINICAL INVESTIGATION

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

Characterization of Programmed Death-1 Homologue-1 (PD-1H) Expression and Function in Normal and HIV Infected Individuals

(2014) Preeti Bharaj et al.   PLoS One

Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity

(2014) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VISTA Is a Novel Broad-Spectrum Negative Checkpoint Regulator for Cancer Immunotherapy

(2014) J. L. Lines et al.   Cancer Immunology Research

The transcription factor PU.1 is critical for viability and function of human brain microglia

(2013) Amy M. Smith et al.   GLIA

Immune checkpoints in central nervous system autoimmunity

(2012) Nicole Joller et al.   IMMUNOLOGICAL REVIEWS

Role of microglia in CNS inflammation

(2011) Manuel B. Graeber et al.   FEBS LETTERS

VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses

(2011) Li Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: A Monoclonal Antibody Specific for the Programmed Death-1 Homolog Prevents Graft-versus-Host Disease in Mouse Models

(2011) D. B. Flies et al.   JOURNAL OF IMMUNOLOGY

Human brain endothelial cells endeavor to immunoregulate CD8 T cells via PD-1 ligand expression in multiple sclerosis

(2011) Camille L Pittet et al.   Journal of Neuroinflammation

CNS Expression of B7-H1 Regulates Pro-Inflammatory Cytokine Production and Alters Severity of Theiler's Virus-Induced Demyelinating Disease

(2011) D'Anne S. Duncan et al.   PLoS One

GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase

(2010) Moustafa A. Sakr et al.   CANCER SCIENCE

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Differentiation of Embryonic Stem Cells 1 (Dies1) Is a Component of Bone Morphogenetic Protein 4 (BMP4) Signaling Pathway Required for Proper Differentiation of Mouse Embryonic Stem Cells

(2009) Luigi Aloia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY