Overexpression of HHLA2 in human clear cell renal cell carcinoma is significantly associated with poor survival of the patients

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Wide Expression and Significance of Alternative Immune Checkpoint Molecules, B7x and HHLA2, in PD-L1–Negative Human Lung Cancers

(2018) Haiying Cheng et al.   CLINICAL CANCER RESEARCH

Upregulated immune checkpoint HHLA2 in clear cell renal cell carcinoma: a novel prognostic biomarker and potential therapeutic target

(2018) Dongming Chen et al.   JOURNAL OF MEDICAL GENETICS

Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma

(2018) David F. McDermott et al.   NATURE MEDICINE

Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma

(2018) Robert J. Motzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

B7-homolog 4 promotes epithelial-mesenchymal transition and invasion of bladder cancer cells via activation of nuclear factor-κB

(2018) Haoran Wu et al.   ONCOLOGY RESEARCH

Immunomodulatory therapies for renal cell carcinoma

(2018) Min Liu et al.   PROTEIN AND PEPTIDE LETTERS

Overexpression of HHLA2, a member of the B7 family, is associated with worse survival in human colorectal carcinoma

(2018) Ziwen Zhu et al.   OncoTargets and Therapy

Decreased RIG-I expression is associated with poor prognosis and promotes cell invasion in human gastric cancer

(2018) Lujun Chen et al.   Cancer Cell International

The role of tivozanib in advanced renal cell carcinoma therapy

(2018) Bernard Escudier et al.   Expert Review of Anticancer Therapy

The third group of the B7-CD28 immune checkpoint family: HHLA2, TMIGD2, B7x, and B7-H3

(2017) Murali Janakiram et al.   IMMUNOLOGICAL REVIEWS

HHLA2, a New Immune Checkpoint Member of the B7 Family, Is Widely Expressed in Human Lung Cancer and Associated with EGFR Mutational Status

(2016) Haiying Cheng et al.   CLINICAL CANCER RESEARCH

Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma

(2016) Y. Lou et al.   CLINICAL CANCER RESEARCH

PD-L1 expression is associated with epithelial-to-mesenchymal transition in adenocarcinoma of the lung

(2016) Sehui Kim et al.   HUMAN PATHOLOGY

Knockdown of B7-H6 inhibits tumor progression and enhances chemosensitivity in B-cell non-Hodgkin lymphoma

(2016) FEIFEI WU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Targeting renal cell carcinoma with a HIF-2 antagonist

(2016) Wenfang Chen et al.   NATURE

PD-L1 expression is associated with epithelial-mesenchymal transition in head and neck squamous cell carcinoma

(2016) Chan-Young Ock et al.   Oncotarget

HHLA2, a member of the B7 family, is expressed in human osteosarcoma and is associated with metastases and worse survival

(2016) Pratistha Koirala et al.   Scientific Reports

B7-H3 promotes aggression and invasion of hepatocellular carcinoma by targeting epithelial-to-mesenchymal transition via JAK2/STAT3/Slug signaling pathway

(2015) Fu-biao Kang et al.   Cancer Cell International

Renal-Cell Cancer — Targeting an Immune Checkpoint or Multiple Kinases

(2015) David I. Quinn et al.   NEW ENGLAND JOURNAL OF MEDICINE

HHLA2 and TMIGD2: new immunotherapeutic targets of the B7 and CD28 families

(2015) Murali Janakiram et al.   OncoImmunology

B7H1 Expression and Epithelial-To-Mesenchymal Transition Phenotypes on Colorectal Cancer Stem-Like Cells

(2015) Yidan Zhi et al.   PLoS One

Expression, Clinical Significance, and Receptor Identification of the Newest B7 Family Member HHLA2 Protein

(2014) M. Janakiram et al.   CLINICAL CANCER RESEARCH

Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells

(2013) N. Fiegler et al.   BLOOD

HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function

(2013) R. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B7-H5 costimulates human T cells via CD28H

(2013) Yuwen Zhu et al.   Nature Communications

Higher numbers of T-bet+ intratumoral lymphoid cells correlate with better survival in gastric cancer

(2012) Lu-jun Chen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

B7-H4 expression associates with cancer progression and predicts patient’s survival in human esophageal squamous cell carcinoma

(2011) Lu-jun Chen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Targeted therapy for patients with renal-cell carcinoma

(2011) Brian I Rini   LANCET ONCOLOGY

Renal cell carcinoma

(2010) Brian I Rini et al.   CURRENT OPINION IN ONCOLOGY

Renal cell carcinoma

(2009) Brian I Rini et al.   LANCET

Tumor Cell and Tumor Vasculature Expression of B7-H3 Predict Survival in Clear Cell Renal Cell Carcinoma

(2008) P. L. Crispen et al.   CLINICAL CANCER RESEARCH