p53 regulates lipid metabolism in cancer

A Mouse Homolog of a Human TP53 Germline Mutation Reveals a Lipolytic Activity of p53

(2020) Ju-Gyeong Kang et al.   Cell Reports

Liver osteopontin is required to prevent the progression of age‐related nonalcoholic fatty liver disease

(2020) Beatriz Gómez‐Santos et al.   AGING CELL

SOAT1 promotes mevalonate pathway dependency in pancreatic cancer

(2020) Tobiloba E. Oni et al.   JOURNAL OF EXPERIMENTAL MEDICINE

p53‐Mediated Repression of the PGC1A (PPARG Coactivator 1α) and APLNR (Apelin Receptor) Signaling Pathways Limits Fatty Acid Oxidation Energetics: Implications for Cardio‐oncology

(2020) Bruno Saleme et al.   Journal of the American Heart Association

The BRD7-P53-SLC25A28 axis regulates ferroptosis in hepatic stellate cells

(2020) Zili Zhang et al.   Redox Biology

The Intricate Role of p53 in Adipocyte Differentiation and Function

(2020) Yun Kyung Lee et al.   Cells

Dysregulation of lysophospholipid signaling by p53 in malignant cells and the tumor microenvironment

(2020) Sue Chin Lee et al.   CELLULAR SIGNALLING

p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake

(2019) Xazmin H. Lowman et al.   Cell Reports

Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA

(2019) Min Wang et al.   CELL DEATH AND DIFFERENTIATION

Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53

(2019) Yufei Wang et al.   EMBO REPORTS

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer

(2019) Matthieu Lacroix et al.   Molecular Metabolism

Reprogramming of fatty acid metabolism in cancer

(2019) Nikos Koundouros et al.   BRITISH JOURNAL OF CANCER

Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer

(2019) Marteinn Thor Snaebjornsson et al.   Cell Metabolism

Lipid metabolism and lipophagy in cancer

(2018) Meenu Maan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p53 mediated regulation of coactivator associated arginine methyltransferase 1 (CARM1) expression is critical for suppression of adipogenesis

(2018) Amit K. Behera et al.   FEBS Journal

p53 and glucose metabolism: an orchestra to be directed in cancer therapy

(2018) Ana Sara Gomes et al.   PHARMACOLOGICAL RESEARCH

ALIMA1variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption

(2018) Ying-Yu Zhang et al.   SCIENCE

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

(2018) Amy Tarangelo et al.   Cell Reports

p53 cooperates with SIRT6 to regulate cardiolipin de novo biosynthesis

(2018) Meiting Li et al.   Cell Death & Disease

The p53/Adipose-Tissue/Cancer Nexus

(2018) Kevin Zwezdaryk et al.   Frontiers in Endocrinology

p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression

(2018) Sung-Hwan Moon et al.   CELL

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2

(2017) Yanhong Zhang et al.   GENES & DEVELOPMENT

Mutant p53 in Cancer: Accumulation, Gain-of-Function, and Therapy

(2017) Xuetian Yue et al.   JOURNAL OF MOLECULAR BIOLOGY

Exogenous lipids promote the growth of breast cancer cells via CD36

(2017) Jing Zhao et al.   ONCOLOGY REPORTS

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

(2017) Yangchun Xie et al.   Cell Reports

p53 regulates expression of uncoupling protein 1 through binding and repression of PPARγ coactivator-1α

(2016) Philip Hallenborg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

DNA Damage and the Activation of the p53 Pathway Mediate Alterations in Metabolic and Secretory Functions of Adipocytes

(2016) Bastien Vergoni et al.   DIABETES

Pharmacological and Genetic Manipulation of p53 in Brown Fat at Adult But Not Embryonic Stages Regulates Thermogenesis and Body Weight in Male Mice

(2016) Omar Al-Massadi et al.   ENDOCRINOLOGY

CerS6Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress

(2016) Baharan Fekry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer metabolism at a glance

(2016) Alexei Vazquez et al.   JOURNAL OF CELL SCIENCE

Activation ofSAT1engages polyamine metabolism with p53-mediated ferroptotic responses

(2016) Yang Ou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

(2016) Shang-Jui Wang et al.   Cell Reports

The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction

(2016) Che-Pei Kung et al.   Cell Reports

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

Fatty acid metabolism and cancer development

(2016) Yuanying Chen et al.   Science Bulletin

Tumor suppressor p53 and its mutants in cancer metabolism

(2015) Juan Liu et al.   CANCER LETTERS

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression

(2015) Zhaoyong Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanisms of p53 degradation

(2015) Chuck C.-K. Chao   CLINICA CHIMICA ACTA

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

(2015) Flore Kruiswijk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

p53 regulates the mevalonate pathway in human glioblastoma multiforme

(2015) C Laezza et al.   Cell Death & Disease

P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest

(2015) A A Shamseddine et al.   Cell Death & Disease

The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis

(2015) Chiara Saponaro et al.   Nutrients

p53 attenuates AKT signaling by modulating membrane phospholipid composition

(2015) Natalia Rueda-Rincon et al.   Oncotarget

Analysis of p53 Transactivation Domain Mutants Reveals Acad11 as a Metabolic Target Important for p53 Pro-Survival Function

(2015) Dadi Jiang et al.   Cell Reports

Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

(2015) Aritro Nath et al.   Scientific Reports

Inhibitory effect of p53 on mitochondrial content and function during adipogenesis

(2014) Naoyuki Okita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of p53 in preadipocyte differentiation

(2014) Qiong Huang et al.   CELL BIOLOGY INTERNATIONAL

De novo lipogenesis in health and disease

(2014) Fatima Ameer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation

(2014) Ge Zhou et al.   MOLECULAR CELL

Lipid landscapes and pipelines in membrane homeostasis

(2014) Joost C.M. Holthuis et al.   NATURE

Leptin Is an Anti-Apoptotic Effector in Placental Cells Involving p53 Downregulation

(2014) Ayelén Rayen Toro et al.   PLoS One

Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation

(2014) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor suppressor p53 and its gain-of-function mutants in cancer

(2013) J. Liu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

p53-dependent regulation of metabolic function through transcriptional activation of pantothenate kinase-1 gene

(2013) Shang-Jui Wang et al.   CELL CYCLE

Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model

(2013) N Sanchez-Macedo et al.   CELL DEATH AND DIFFERENTIATION

p53 is required for brown adipogenic differentiation and has a protective role against diet-induced obesity

(2013) A Molchadsky et al.   CELL DEATH AND DIFFERENTIATION

Semaphorin3E-Induced Inflammation Contributes to Insulin Resistance in Dietary Obesity

(2013) Ippei Shimizu et al.   Cell Metabolism

Inflammation and insulin resistance exert dual effects on adipose tissue tumor protein 53 expression

(2013) F J Ortega et al.   INTERNATIONAL JOURNAL OF OBESITY

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

(2013) Peng Jiang et al.   NATURE

Glioma tumor grade correlates with parkin depletion in mutant p53-linked tumors and results from loss of function of p53 transcriptional activity

(2013) J Viotti et al.   ONCOGENE

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

p53-Induced Adipose Tissue Inflammation Is Critically Involved in the Development of Insulin Resistance in Heart Failure

(2012) Ippei Shimizu et al.   Cell Metabolism

FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

(2012) Rudolf Zechner et al.   Cell Metabolism

Omentin-1, a new adipokine, promotes apoptosis through regulating Sirt1-dependent p53 deacetylation in hepatocellular carcinoma cells

(2012) Yuan-Yuan Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lipid metabolism in cancer

(2012) Claudio R. Santos et al.   FEBS Journal

Mdm2 and MdmX partner to regulate p53

(2012) Xinjiang Wang et al.   FEBS LETTERS

Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis

(2012) Dania Daye et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A new role of p53 in regulating lipid metabolism

(2012) Xingwu Wang et al.   Journal of Molecular Cell Biology

Sirtuin 1 in lipid metabolism and obesity

(2011) Thaddeus T. Schug et al.   ANNALS OF MEDICINE

The integral role of mTOR in lipid metabolism

(2011) Ghada A. Soliman   CELL CYCLE

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

(2011) K. Zaugg et al.   GENES & DEVELOPMENT

p53-inducible DHRS3 Is an Endoplasmic Reticulum Protein Associated with Lipid Droplet Accumulation

(2011) Chad Deisenroth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Many Ceramides

(2011) Yusuf A. Hannun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53, a novel regulator of lipid metabolism pathways

(2011) Ido Goldstein et al.   JOURNAL OF HEPATOLOGY

Feedback Control of p53 Translation by REDD1 and mTORC1 Limits the p53-Dependent DNA Damage Response

(2011) D. D. Vadysirisack et al.   MOLECULAR AND CELLULAR BIOLOGY

Immunity as a link between obesity and insulin resistance

(2011) Nishan S. Kalupahana et al.   MOLECULAR ASPECTS OF MEDICINE

ROS-Mediated p53 Induction of Lpin1 Regulates Fatty Acid Oxidation in Response to Nutritional Stress

(2011) Wissam Assaily et al.   MOLECULAR CELL

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

Defining a role for sphingosine kinase 1 in p53-dependent tumors

(2011) L A Heffernan-Stroud et al.   ONCOGENE

Tumor suppressor p53 regulates bile acid homeostasis via small heterodimer partner

(2011) D.-H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

(2011) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipokines as novel biomarkers and regulators of the metabolic syndrome

(2010) Yingfeng Deng et al.   Annals of the New York Academy of Sciences

Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice

(2010) Dan Ye et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

apoB and apobec1, two genes key to lipid metabolism, are transcriptionally regulated by p53

(2010) Osnat Ashur-Fabian et al.   CELL CYCLE

The role of p53 in glucose metabolism

(2010) Eric C Cheung et al.   CURRENT OPINION IN CELL BIOLOGY

Identification and characterization of new long chain Acyl-CoA dehydrogenases

(2010) Miao He et al.   MOLECULAR GENETICS AND METABOLISM

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein

(2010) Zhaohui Feng et al.   TRENDS IN CELL BIOLOGY

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Posttranslational Modification of p53: Cooperative Integrators of Function

(2009) D. W. Meek et al.   Cold Spring Harbor Perspectives in Biology

Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases

(2008) James P. Hardwick   BIOCHEMICAL PHARMACOLOGY

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

CARM1 promotes adipocyte differentiation by coactivating PPARγ

(2008) Neelu Yadav et al.   EMBO REPORTS

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

p53 Plays a Role in Mesenchymal Differentiation Programs, in a Cell Fate Dependent Manner

(2008) Alina Molchadsky et al.   PLoS One

A Mouse Model of Harlequin Ichthyosis Delineates a Key Role for Abca12 in Lipid Homeostasis

(2008) Ian Smyth et al.   PLoS Genetics