Mdm2 and MdmX partner to regulate p53

The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior

(2011) Yan Liu et al.   CELL CYCLE

Regulation of p53 stability and function by the deubiquitinating enzyme USP42

(2011) Andreas K Hock et al.   EMBO JOURNAL

p53 regulation by ubiquitin

(2011) Christopher L. Brooks et al.   FEBS LETTERS

Inactivation ofarf-bp1Induces p53 Activation and Diabetic Phenotypes in Mice

(2011) Ning Kon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E3 Ligases Determine Ubiquitination Site and Conjugate Type by Enforcing Specificity on E2 Enzymes

(2011) Yael David et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MdmX Protein Is Essential for Mdm2 Protein-mediated p53 Polyubiquitination

(2011) Xinjiang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Critical Role for Noncoding 5S rRNA in Regulating Mdmx Stability

(2011) Muyang Li et al.   MOLECULAR CELL

UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53

(2011) Hong Wu et al.   NATURE MEDICINE

Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11

(2011) Masato Sasaki et al.   NATURE MEDICINE

Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability

(2011) V. Pant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo

(2011) L. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Pirh2 in Mediating the Regulation of p53 and c-Myc

(2011) Anne Hakem et al.   PLoS Genetics

Making sense of ubiquitin ligases that regulate p53

(2010) Abhinav K. Jain et al.   CANCER BIOLOGY & THERAPY

USP10 Regulates p53 Localization and Stability by Deubiquitinating p53

(2010) Jian Yuan et al.   CELL

Unlocking the Mdm2-p53 loop: Ubiquitin is the key

(2010) Hilary V. Clegg et al.   CELL CYCLE

p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors

(2010) Baozong Li et al.   CELL CYCLE

HDMX-L Is Expressed from a Functional p53-responsive Promoter in the First Intron of theHDMXGene and Participates in an Autoregulatory Feedback Loop to Control p53 Activity

(2010) Anna Phillips et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E2 Ubiquitin-conjugating Enzymes Direct Polyubiquitination to Preferred Lysines

(2010) Yael David et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Abl Phosphorylation of Mdm2 Facilitates Mdm2-Mdmx Complex Formation

(2010) David L. Waning et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The p53 orchestra: Mdm2 and Mdmx set the tone

(2010) Mark Wade et al.   TRENDS IN CELL BIOLOGY

Increased Radioresistance and Accelerated B Cell Lymphomas in Mice with Mdmx Mutations that Prevent Modifications by DNA-Damage-Activated Kinases

(2009) Yunyuan V. Wang et al.   CANCER CELL

Signaling to p53: Ribosomal Proteins Find Their Way

(2009) Yanping Zhang et al.   CANCER CELL

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Mdm2-mediated ubiquitylation: p53 and beyond

(2009) J-C Marine et al.   CELL DEATH AND DIFFERENTIATION

ATM activates p53 by regulating MDM2 oligomerization and E3 processivity

(2009) Qian Cheng et al.   EMBO JOURNAL

Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase

(2009) Koji Okamoto et al.   FEBS LETTERS

Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes

(2009) Joerg Kallen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation of HAUSP in vivo modulates p53 function

(2009) N Kon et al.   ONCOGENE

MdmX is a substrate for the deubiquitinating enzyme USP2a

(2009) N Allende-Vega et al.   ONCOGENE

JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation

(2009) L. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53

(2009) D. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRL4s: the CUL4-RING E3 ubiquitin ligases

(2009) Sarah Jackson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Posttranslational Modification of p53: Cooperative Integrators of Function

(2009) D. W. Meek et al.   Cold Spring Harbor Perspectives in Biology

Acetylation Is Indispensable for p53 Activation

(2008) Yi Tang et al.   CELL

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

(2008) K Linke et al.   CELL DEATH AND DIFFERENTIATION

Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26

(2008) Yaara Ofir-Rosenfeld et al.   MOLECULAR CELL