Microbial arginine deiminase: A multifaceted green catalyst in biomedical sciences

Intracellular arginine-dependent translation sensor reveals the dynamics of arginine starvation response and resistance in ASS1-negative cells

(2021) Leonard C. Rogers et al.   Cancer & Metabolism

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Arginine deprivation as a strategy for cancer therapy: An insight into drug design and drug combination

(2021) Yu Zhang et al.   CANCER LETTERS

Microbial enzymes for deprivation of amino acid metabolism in malignant cells: biological strategy for cancer treatment

(2020) Rakhi Dhankhar et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A virus that has gone viral: amino acid mutation in S protein of Indian isolate of Coronavirus COVID-19 might impact receptor binding, and thus, infectivity

(2020) Priyanka Saha et al.   BIOSCIENCE REPORTS

Electrochemical determination of L-arginine in leukemic blood samples based on a polyaniline-multiwalled carbon nanotube—magnetite nanocomposite film modified glassy carbon electrode

(2020) Ashish Kumar Singh et al.   INSTRUMENTATION SCIENCE & TECHNOLOGY

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

The Arginine Deiminase Pathway Impacts Antibiotic Tolerance during Biofilm-Mediated Streptococcus pyogenes Infections

(2020) Jeffrey A. Freiberg et al.   mBio

Biomedical applications of microbial phenylalanine ammonia lyase: Current status and future prospects

(2020) Anubhuti Kawatra et al.   BIOCHIMIE

Design of a structure-based fluorescent biosensor from bioengineered arginine deiminase for rapid determination of L-arginine

(2020) Suet-Ying Tam et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Arginine depletion as a therapeutic approach for patients with COVID-19

(2020) Joseph M. Grimes et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Rational surface engineering of an arginine deiminase (an anti‐tumor enzyme) for increased PEGylation efficiency

(2019) Feng Cheng et al.   BIOTECHNOLOGY AND BIOENGINEERING

Cell penetrating peptide: Sequence-based computational prediction for intercellular delivery of arginine deiminase

(2019) Mahboubeh Zarei et al.   Current Proteomics

Multilevel algorithms and evolutionary hybrid tools for enhanced production of arginine deiminase from Pseudomonas furukawaii RS3

(2019) Rakhi Dhankhar et al.   BIORESOURCE TECHNOLOGY

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Aspergillus nidulans thermostable arginine deiminase-Dextran conjugates with enhanced molecular stability, proteolytic resistance, pharmacokinetic properties and anticancer activity

(2019) Ashraf S.A. El-Sayed et al.   ENZYME AND MICROBIAL TECHNOLOGY

Loop engineering reveals the importance of active-site-decorating loops and gating residue in substrate affinity modulation of arginine deiminase (an anti-tumor enzyme)

(2018) Feng Cheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Medium Optimization for Recombinant Soluble Arginine Deiminase Expression in Escherichia coli Using Response Surface Methodology

(2018) Mahboubeh Zarei et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Decreasing the immunogenicity of arginine deiminase enzyme via structure‐based computational analysis

(2018) Mahboubeh Zarei et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Characterization of a recombinant arginine deiminase from Enterococcus faecalis SK32.001 for L-citrulline production

(2018) Hangyu Jiang et al.   PROCESS BIOCHEMISTRY

Arginine-lowering enzymes against cancer: a technocommercial analysis through patent landscape

(2018) Rakhi Dhankhar et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Thermostability and Specific-Activity Enhancement of an Arginine Deiminase from Enterococcus faecalis SK23.001 via Semirational Design for l-Citrulline Production

(2018) Xue Cai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Amperometric L-arginine biosensor based on a novel recombinant arginine deiminase

(2017) Mykhailo T. Zhybak et al.   MICROCHIMICA ACTA

Citrulline in health and disease. Review on human studies

(2017) Cinzia Papadia et al.   CLINICAL NUTRITION

Arginine deiminase pathway enzymes: evolutionary history in metamonads and other eukaryotes

(2016) Lukáš Novák et al.   BMC EVOLUTIONARY BIOLOGY

Arginine dependence of tumor cells: targeting a chink in cancer’s armor

(2016) M D Patil et al.   ONCOGENE

Hydrophobic Mutagenesis and Semi-rational Engineering of Arginine Deiminase for Markedly Enhanced Stability and Catalytic Efficiency

(2015) Serwanja Jamil et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Extracellular expression of natural cytosolic arginine deiminase from Pseudomonas putida and its application in the production of l -citrulline

(2015) Lingqia Su et al.   BIORESOURCE TECHNOLOGY

Purification, immobilization, and biochemical characterization ofl-arginine deiminase from thermophilicAspergillus fumigatusKJ434941: Anticancer activityin vitro

(2015) Ashraf S. A. El-Sayed et al.   BIOTECHNOLOGY PROGRESS

PEGylation and pharmacological characterization of a potential anti-tumor drug, an engineered arginine deiminase originated from Pseudomonas plecoglossicida

(2015) Long Zhang et al.   CANCER LETTERS

Citrulline Protects Streptococcus pyogenes from Acid Stress Using the Arginine Deiminase Pathway and the F1Fo-ATPase

(2015) Zachary T. Cusumano et al.   JOURNAL OF BACTERIOLOGY

Escherichia coli EDA is a novel fusion expression partner to improve solubility of aggregation-prone heterologous proteins

(2015) Yoon-Sik Kang et al.   JOURNAL OF BIOTECHNOLOGY

Enzymatic production of l-citrulline by hydrolysis of the guanidinium group of l-arginine with recombinant arginine deiminase

(2015) Wei Song et al.   JOURNAL OF BIOTECHNOLOGY

Selective Intracellular Delivery of Recombinant Arginine Deiminase (ADI) Using pH-Sensitive Cell Penetrating Peptides To Overcome ADI Resistance in Hypoxic Breast Cancer Cells

(2015) Tzyy-Harn Yeh et al.   MOLECULAR PHARMACEUTICS

Directed arginine deiminase evolution for efficient inhibition of arginine-auxotrophic melanomas

(2014) Feng Cheng et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Cultivation to improve in vivo solubility of overexpressed arginine deiminases in Escherichia coli and the enzyme characteristics

(2014) Ying Wang et al.   BMC BIOTECHNOLOGY

Synthesis of Mycoplasma arginine deiminase in E. coli using stress-responsive proteins

(2014) Keum-Young Ahn et al.   ENZYME AND MICROBIAL TECHNOLOGY

Intracellular Delivery of Recombinant Arginine Deiminase (rADI) by Heparin-Binding Hemagglutinin Adhesion Peptide Restores Sensitivity in rADI-Resistant Cancer Cells

(2014) Fe-Lin Lin Wu et al.   MOLECULAR PHARMACEUTICS

Depletion of Arginine by Recombinant Arginine Deiminase Induces nNOS-Activated Neurotoxicity in Neuroblastoma Cells

(2014) Shan-Erh Lin et al.   Biomed Research International

Protein Engineering of the Antitumor Enzyme PpADI for Improved Thermal Resistance

(2013) Leilei Zhu et al.   CHEMBIOCHEM

Improved method for expression and isolation of the Mycoplasma hominis arginine deiminase from the recombinant strain of Escherichia coli

(2013) Lyubov R. Fayura et al.   JOURNAL OF BIOTECHNOLOGY

Inducible Nitric Oxide Contributes to Viral Pathogenesis Following Highly Pathogenic Influenza Virus Infection in Mice

(2013) Lucy A. Perrone et al.   JOURNAL OF INFECTIOUS DISEASES

Arginine Deiminase Resistance in Melanoma Cells Is Associated with Metabolic Reprogramming, Glucose Dependence, and Glutamine Addiction

(2013) Yan Long et al.   MOLECULAR CANCER THERAPEUTICS

Kinetic characterization of arginine deiminase and carbamate kinase from Streptococcus pyogenes M49

(2013) Silvio Hering et al.   PROTEIN EXPRESSION AND PURIFICATION

Negative argininosuccinate synthetase expression in melanoma tumours may predict clinical benefit from arginine-depleting therapy with pegylated arginine deiminase

(2012) L G Feun et al.   BRITISH JOURNAL OF CANCER

Expression ofSTM4467-Encoded Arginine Deiminase Controlled by theSTM4463Regulator Contributes to Salmonella enterica Serovar Typhimurium Virulence

(2012) Younho Choi et al.   INFECTION AND IMMUNITY

Rapid evolution of arginine deiminase for improved anti-tumor activity

(2011) Ye Ni et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Protein resistance of dextran and dextran-poly(ethylene glycol) copolymer films

(2011) Darby Kozak et al.   BIOFOULING

A novel Escherichia coli solubility enhancer protein for fusion expression of aggregation-prone heterologous proteins

(2011) Jong-Am Song et al.   ENZYME AND MICROBIAL TECHNOLOGY

A Potential Antitumor Drug (Arginine Deiminase) Reengineered for Efficient Operation under Physiological Conditions

(2010) Leilei Zhu et al.   CHEMBIOCHEM

Directed Evolution of an Antitumor Drug (Arginine Deiminase PpADI) for Increased Activity at Physiological pH

(2010) Leilei Zhu  et al.   CHEMBIOCHEM

Arginine deiminase, a potential anti-tumor drug

(2008) Ye Ni et al.   CANCER LETTERS

Molecular characterization of the arginine deiminase system inListeria monocytogenes: regulation and role in acid tolerance

(2008) Sheila Ryan et al.   ENVIRONMENTAL MICROBIOLOGY

Inactivation of Microbial Arginine Deiminases byl-Canavanine

(2008) Ling Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Isolation and identification of an arginine deiminase producing strain Pseudomonas plecoglossicida CGMCC2039

(2008) Yong-Mei Liu et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY