Microbial enzymes for deprivation of amino acid metabolism in malignant cells: biological strategy for cancer treatment

Thermosensitive Micelles Encapsulating Phenylalanine Ammonia Lyase Act as a Sustained and Efficacious Therapy Against Colorectal Cancer

(2019) Jin Yang et al.   Journal of Biomedical Nanotechnology

A Review of the Microbial Production of Bioactive Natural Products and Biologics

(2019) Janette V. Pham et al.   Frontiers in Microbiology

Amino acid metabolism in hematologic malignancies and the era of targeted therapy

(2019) Yoko Tabe et al.   BLOOD

Arginine metabolism and deprivation in cancer therapy

(2019) Songyun Zou et al.   BIOMEDICINE & PHARMACOTHERAPY

Multilevel algorithms and evolutionary hybrid tools for enhanced production of arginine deiminase from Pseudomonas furukawaii RS3

(2019) Rakhi Dhankhar et al.   BIORESOURCE TECHNOLOGY

Asparagine bioavailability governs metastasis in a model of breast cancer

(2018) Simon R. V. Knott et al.   NATURE

Characterization of a recombinant arginine deiminase from Enterococcus faecalis SK32.001 for L-citrulline production

(2018) Hangyu Jiang et al.   PROCESS BIOCHEMISTRY

Abstract LB-247: Targeting methionine metabolism to eradicate cancer stem cells

(2018) Elena Strekalova et al.   CANCER RESEARCH

Arginine-lowering enzymes against cancer: a technocommercial analysis through patent landscape

(2018) Rakhi Dhankhar et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Arginine deiminase: recent advances in discovery, crystal structure, and protein engineering for improved properties as an anti-tumor drug

(2016) Rui-Zhi Han et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice

(2016) J. R. Hens et al.   BMC CANCER

Current applications and different approaches for microbial l-asparaginase production

(2016) Jorge Javier Muso Cachumba et al.   BRAZILIAN JOURNAL OF MICROBIOLOGY

Recent developments in l-asparaginase discovery and its potential as anticancer agent

(2016) Abhinav Shrivastava et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Amino acid deprivation using enzymes as a targeted therapy for cancer and viral infections

(2016) H. S. Fernandes et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs

(2016) Peter L. Turecek et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Arginine dependence of tumor cells: targeting a chink in cancer’s armor

(2016) M D Patil et al.   ONCOGENE

World Cancer Report 2014. Geneva, Switzerland: World Health Organization, International Agency for Research on Cancer, WHO Press, 2015

(2016) Shelley McGuire   Advances in Nutrition

PEGylation in anti-cancer therapy: An overview

(2016) Prajna Mishra et al.   Asian Journal of Pharmaceutical Sciences

Fusion Proteins for Half-Life Extension of Biologics as a Strategy to Make Biobetters

(2015) William R. Strohl   BIODRUGS

The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential

(2015) Stephen H.K. Wong et al.   CANCER CELL

PEGylation and pharmacological characterization of a potential anti-tumor drug, an engineered arginine deiminase originated from Pseudomonas plecoglossicida

(2015) Long Zhang et al.   CANCER LETTERS

Recombinant expression, molecular characterization and crystal structure of antitumor enzyme, L-lysine  -oxidase from Trichoderma viride

(2015) M. Amano et al.   JOURNAL OF BIOCHEMISTRY

Arginase: an old enzyme with new tricks

(2015) Ruth B. Caldwell et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Optimization and purification of anticancer enzyme L-glutaminase from Alcaligenes faecalis KLU102

(2015) Sureshbabu Pandian et al.   BIOLOGIA

Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes

(2015)   Oncotarget

Synthesis of Mycoplasma arginine deiminase in E. coli using stress-responsive proteins

(2014) Keum-Young Ahn et al.   ENZYME AND MICROBIAL TECHNOLOGY

Development of recombinant methioninase to target the general cancer-specific metabolic defect of methionine dependence: a 40-year odyssey

(2014) Robert M Hoffman   EXPERT OPINION ON BIOLOGICAL THERAPY

Crystal structure of active site mutant of antileukemicl-asparaginase reveals conserved zinc-binding site

(2014) Dominika Borek et al.   FEBS Journal

Cell-penetrating peptides meditated encapsulation of protein therapeutics into intact red blood cells and its application

(2014) Huining He et al.   JOURNAL OF CONTROLLED RELEASE

Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

(2014) M. I. Gross et al.   MOLECULAR CANCER THERAPEUTICS

Control of the translational machinery by amino acids

(2013) Christopher G Proud   AMERICAN JOURNAL OF CLINICAL NUTRITION

Functional amino acids in nutrition and health

(2013) Guoyao Wu   AMINO ACIDS

Enzymatic properties and anticancer activity of L-lysine α-oxidase from Trichoderma cf. aureoviride Rifai BKMF-4268D

(2013) Vadim S. Pokrovsky et al.   ANTI-CANCER DRUGS

Biochemical Characterization and Antitumor Study of l-Glutaminase from Bacillus cereus MTCC 1305

(2013) P. Singh et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Recombinantl-phenylalanine ammonia lyase fromRhodosporidium toruloidesas a potential anticancer agent

(2013) Olga O. Babich et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Therapeutic strategies impacting cancer cell glutamine metabolism

(2013) Michael J Lukey et al.   Future Medicinal Chemistry

Red blood cells as innovative antigen carrier to induce specific immune tolerance

(2013) Magali Cremel et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Glutamine and cancer: cell biology, physiology, and clinical opportunities

(2013) Christopher T. Hensley et al.   JOURNAL OF CLINICAL INVESTIGATION

Efficient production of l-asparaginase from Bacillus licheniformis with low-glutaminase activity: Optimization, scale up and acrylamide degradation studies

(2012) Richi V. Mahajan et al.   BIORESOURCE TECHNOLOGY

A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension

(2012) Paul Cavuoto et al.   CANCER TREATMENT REVIEWS

Breathless cancer cells get fat on glutamine

(2012) Dimitrios Anastasiou et al.   CELL RESEARCH

A phase 1 dose-escalating study of pegylated recombinant human arginase 1 (Peg-rhArg1) in patients with advanced hepatocellular carcinoma

(2012) Thomas Yau et al.   INVESTIGATIONAL NEW DRUGS

TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation

(2012) Min You et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

l-asparaginase loaded red blood cells in refractory or relapsing acute lymphoblastic leukaemia in children and adults: results of the GRASPALL 2005-01 randomized trial

(2011) Carine Domenech et al.   BRITISH JOURNAL OF HAEMATOLOGY

A novel Escherichia coli solubility enhancer protein for fusion expression of aggregation-prone heterologous proteins

(2011) Jong-Am Song et al.   ENZYME AND MICROBIAL TECHNOLOGY

Microbial l-methioninase: production, molecular characterization, and therapeutic applications

(2010) Ashraf S. El-Sayed   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

A Potential Antitumor Drug (Arginine Deiminase) Reengineered for Efficient Operation under Physiological Conditions

(2010) Leilei Zhu et al.   CHEMBIOCHEM

Amino acids: metabolism, functions, and nutrition

(2009) Guoyao Wu   AMINO ACIDS

Growth Inhibition of Human Melanoma Cells by a Recombinant Arginine Deiminase Expressed in Escherichia coli

(2009) Megumi KOZAI et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Arginine deiminase, a potential anti-tumor drug

(2008) Ye Ni et al.   CANCER LETTERS

Anti-cancer PEG-enzymes: 30 years old, but still a current approach

(2007) Gianfranco Pasut et al.   ADVANCED DRUG DELIVERY REVIEWS