Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity

Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population

(2021) Lachlan Harris et al.   Cell Stem Cell

Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life

(2020) Gabriel Berdugo-Vega et al.   Nature Communications

Aging and Rejuvenation of Neural Stem Cells and Their Niches

(2020) Paloma Navarro Negredo et al.   Cell Stem Cell

High Hes1 expression and resultant Ascl1 suppression regulate quiescent vs. active neural stem cells in the adult mouse brain

(2019) Risa Sueda et al.   GENES & DEVELOPMENT

A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis

(2019) Daniel A. Berg et al.   CELL

Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain

(2019) Georgios Kalamakis et al.   CELL

Accelerated bio-cognitive aging in Down syndrome: State of the art and possible deceleration strategies

(2019) Claudio Franceschi et al.   AGING CELL

Functions of adult-born neurons in hippocampal memory interference and indexing

(2019) Samara M. Miller et al.   NATURE NEUROSCIENCE

Id4 Downstream of Notch2 Maintains Neural Stem Cell Quiescence in the Adult Hippocampus

(2019) Runrui Zhang et al.   Cell Reports

Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells

(2019) Isabelle Maria Blomfield et al.   eLife

Enhanced lysosomal degradation maintains the quiescent state of neural stem cells

(2019) Taeko Kobayashi et al.   Nature Communications

Quiescence of Adult Mammalian Neural Stem Cells: A Highly Regulated Rest

(2019) Noelia Urbán et al.   NEURON

Human Adult Neurogenesis: Evidence and Remaining Questions

(2018) Gerd Kempermann et al.   Cell Stem Cell

Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing

(2018) Hannah Hochgerner et al.   NATURE NEUROSCIENCE

Live imaging of neurogenesis in the adult mouse hippocampus

(2018) Gregor-Alexander Pilz et al.   SCIENCE

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

(2018) Dena S. Leeman et al.   SCIENCE

Notch2 Signaling Maintains NSC Quiescence in the Murine Ventricular-Subventricular Zone

(2018) Anna Engler et al.   Cell Reports

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

(2018) Se Hoon Choi et al.   SCIENCE

Noggin rescues age-related stem cell loss in the brain of senescent mice with neurodegenerative pathology

(2018) María Díaz-Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increasing Neural Stem Cell Division Asymmetry and Quiescence Are Predicted to Contribute to the Age-Related Decline in Neurogenesis

(2018) Lisa Bast et al.   Cell Reports

Plag1 and Plagl2 have overlapping and distinct functions in telencephalic development

(2018) Lata Adnani et al.   Biology Open

Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene network

(2017) Annie Varrault et al.   NUCLEIC ACIDS RESEARCH

Single-Cell Transcriptomic Analysis Defines Heterogeneity and Transcriptional Dynamics in the Adult Neural Stem Cell Lineage

(2017) Ben W. Dulken et al.   Cell Reports

A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche

(2017) Benedetta Artegiani et al.   Cell Reports

Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior

(2016) J. Tiago Gonçalves et al.   CELL

Return to quiescence of mouse neural stem cells by degradation of a proactivation protein

(2016) Noelia Urbán et al.   SCIENCE

Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis

(2015) Jaehoon Shin et al.   Cell Stem Cell

Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury

(2015) Enric Llorens-Bobadilla et al.   Cell Stem Cell

Adult Neurogenesis and the Future of the Rejuvenating Brain Circuits

(2015) Gabriel Lepousez et al.   NEURON

A Transcriptional Mechanism Integrating Inputs from Extracellular Signals to Activate Hippocampal Stem Cells

(2014) Jimena Andersen et al.   NEURON

Sustained Mobilization of Endogenous Neural Progenitors Delays Disease Progression in a Transgenic Model of Huntington’s Disease

(2013) Abdellatif Benraiss et al.   Cell Stem Cell

Loss of Dickkopf-1 Restores Neurogenesis in Old Age and Counteracts Cognitive Decline

(2013) Désirée R.M. Seib et al.   Cell Stem Cell

Secreted Frizzled-Related Protein 3 Regulates Activity-Dependent Adult Hippocampal Neurogenesis

(2013) Mi-Hyeon Jang et al.   Cell Stem Cell

Epigenomic enhancer annotation reveals a key role for NFIX in neural stem cell quiescence

(2013) B. Martynoga et al.   GENES & DEVELOPMENT

Neural Stem Cells: Generating and Regenerating the Brain

(2013) Fred H. Gage et al.   NEURON

Oscillatory Control of Factors Determining Multipotency and Fate in Mouse Neural Progenitors

(2013) I. Imayoshi et al.   SCIENCE

An Optimized microRNA Backbone for Effective Single-Copy RNAi

(2013) Christof Fellmann et al.   Cell Reports

Neurogenic Subventricular Zone Stem/Progenitor Cells Are Notch1-Dependent in Their Active But Not Quiescent State

(2012) O. Basak et al.   JOURNAL OF NEUROSCIENCE

In Vivo Clonal Analysis Reveals Self-Renewing and Multipotent Adult Neural Stem Cell Characteristics

(2011) Michael A. Bonaguidi et al.   CELL

Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus

(2011) Juan M. Encinas et al.   Cell Stem Cell

Overexpression of cdk4 and cyclinD1 triggers greater expansion of neural stem cells in the adult mouse brain

(2011) Benedetta Artegiani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PLAGL2 Regulates Wnt Signaling to Impede Differentiation in Neural Stem Cells and Gliomas

(2010) Hongwu Zheng et al.   CANCER CELL

Quiescent and Active Hippocampal Neural Stem Cells with Distinct Morphologies Respond Selectively to Physiological and Pathological Stimuli and Aging

(2010) Sebastian Lugert et al.   Cell Stem Cell

Signaling through BMPR-IA Regulates Quiescence and Long-Term Activity of Neural Stem Cells in the Adult Hippocampus

(2010) Helena Mira et al.   Cell Stem Cell

RBPJ -Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus

(2010) O. Ehm et al.   JOURNAL OF NEUROSCIENCE

Notch1 Is Required for Maintenance of the Reservoir of Adult Hippocampal Stem Cells

(2010) J. L. Ables et al.   JOURNAL OF NEUROSCIENCE

Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains

(2010) I. Imayoshi et al.   JOURNAL OF NEUROSCIENCE

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Hmga2 Promotes Neural Stem Cell Self-Renewal in Young but Not Old Mice by Reducing p16Ink4a and p19Arf Expression

(2008) Jinsuke Nishino et al.   CELL

Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain

(2008) Itaru Imayoshi et al.   NATURE NEUROSCIENCE

Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer’s disease

(2007) Soo-Ryoon Ryoo et al.   JOURNAL OF NEUROCHEMISTRY