Breaking barriers: Neurodegenerative repercussions of radiotherapy induced damage on the blood-brain and blood-tumor barrier

ANG1005, a brain penetrating peptide-drug conjugate, shows activity in patients with breast cancer with leptomeningeal carcinomatosis and recurrent brain metastases

(2020) Priya Kumthekar et al.   CLINICAL CANCER RESEARCH

A retrospective qualitative report of symptoms and safety from transcranial focused ultrasound for neuromodulation in humans

(2020) Wynn Legon et al.   Scientific Reports

Brain irradiation leads to persistent neuroinflammation and long-term neurocognitive dysfunction in a region-specific manner

(2020) Julie Constanzo et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Glymphatic failure as a final common pathway to dementia

(2020) Maiken Nedergaard et al.   SCIENCE

Astrocytes: News about Brain Health and Diseases

(2020) Jacopo Meldolesi   Biomedicines

Exploratory Analysis of Qualitative MR Imaging Features for the Differentiation of Glioblastoma and Brain Metastases

(2020) Raphael Meier et al.   Frontiers in Oncology

Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies

(2019) Chrysovalantis Voutouri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rho Flares Repair Local Tight Junction Leaks

(2019) Rachel E. Stephenson et al.   DEVELOPMENTAL CELL

Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species

(2019) Pierre Montay-Gruel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired Glymphatic Transport in Spontaneously Hypertensive Rats

(2019) Kristian Nygaard Mortensen et al.   JOURNAL OF NEUROSCIENCE

Transcytosis at the blood–brain barrier

(2019) Swathi Ayloo et al.   CURRENT OPINION IN NEUROBIOLOGY

The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke

(2019) Yilong Shan et al.   Journal of Neuroinflammation

First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound

(2019) Agessandro Abrahao et al.   Nature Communications

Protein Expression and Functional Relevance of Efflux and Uptake Drug Transporters at the Blood–Brain Barrier of Human Brain and Glioblastoma

(2019) Xun Bao et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges

(2018) Dai Fukumura et al.   Nature Reviews Clinical Oncology

Reactive astrocytic S1P3 signaling modulates the blood–tumor barrier in brain metastases

(2018) Brunilde Gril et al.   Nature Communications

Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a

(2018) Shweta Tiwary et al.   Scientific Reports

Capillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection

(2018) Luis Alarcon-Martinez et al.   eLife

Distribution of 4-Hydroxynonenal-Protein Conjugates as a Marker of Lipid Peroxidation and Parameter of Malignancy in Astrocytic and Ependymal Tumors of the Brain

(2018) Gordana Juric-Sekhar et al.   TUMORI

Can We Design a Nogo Receptor-Dependent Cellular Therapy to Target MS?

(2018) Min Kim et al.   Cells

Oxidative stress in the choroid plexus contributes to blood–cerebrospinal fluid barrier disruption during sepsis development

(2018) Mariana Pereira Goldim et al.   MICROVASCULAR RESEARCH

Loss of Pericytes in Radiation Necrosis after Glioblastoma Treatments

(2017) Soon-Tae Lee et al.   MOLECULAR NEUROBIOLOGY

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

(2017) Pierre Montay-Gruel et al.   RADIOTHERAPY AND ONCOLOGY

Blood–tumor barrier opening changes in brain metastases from pre to one-month post radiation therapy

(2017) Feifei Teng et al.   RADIOTHERAPY AND ONCOLOGY

Brain Pericytes As Mediators of Neuroinflammation

(2017) Justin Rustenhoven et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP 5+

(2017) David Leu et al.   Redox Biology

Acute effects of focused ultrasound-induced increases in blood-brain barrier permeability on rat microvascular transcriptome

(2017) Dallan McMahon et al.   Scientific Reports

Alterations in Pericyte Subpopulations Are Associated with Elevated Blood-Tumor Barrier Permeability in Experimental Brain Metastasis of Breast Cancer

(2016) L. T. Lyle et al.   CLINICAL CANCER RESEARCH

Nonclinical Safety and Toxicokinetics of MnTnBuOE-2-PyP5+ (BMX-001)

(2016) Shayne Cox Gad et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Pericytes as Inducers of Rapid, Matrix Metalloproteinase-9-Dependent Capillary Damage during Ischemia

(2016) Robert G. Underly et al.   JOURNAL OF NEUROSCIENCE

Neural correlates of single-vessel haemodynamic responses in vivo

(2016) Philip O’Herron et al.   NATURE

Disrupting the blood–brain barrier by focused ultrasound induces sterile inflammation

(2016) Zsofia I. Kovacs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown

(2016) Yu Yamazaki et al.   STROKE

Evaluating Changes to Blood-Brain Barrier Integrity in Brain Metastasis over Time and after Radiation Treatment

(2016) Donna H. Murrell et al.   Translational Oncology

Targeting Receptor-Mediated Transport for Delivery of Biologics Across the Blood-Brain Barrier

(2015) Jason M. Lajoie et al.   Annual Review of Pharmacology and Toxicology

Activation of eNOS in endothelial cells exposed to ionizing radiation involves components of the DNA damage response pathway

(2015) Masaki Nagane et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Astrocytic TYMP and VEGFA drive blood–brain barrier opening in inflammatory central nervous system lesions

(2015) Candice Chapouly et al.   BRAIN

Ultra-fast magnetic resonance encephalography of physiological brain activity – Glymphatic pulsation mechanisms?

(2015) Vesa Kiviniemi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Integrative Proteomics and Targeted Transcriptomics Analyses in Cardiac Endothelial Cells Unravel Mechanisms of Long-Term Radiation-Induced Vascular Dysfunction

(2015) Omid Azimzadeh et al.   JOURNAL OF PROTEOME RESEARCH

A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome

(2015) Vafa Alakbarzade et al.   NATURE GENETICS

The Glymphatic System: A Beginner’s Guide

(2015) Nadia Aalling Jessen et al.   NEUROCHEMICAL RESEARCH

Radiation and Inflammation

(2015) Dörthe Schaue et al.   SEMINARS IN RADIATION ONCOLOGY

Facilitation of Drug Transport across the Blood–Brain Barrier with Ultrasound and Microbubbles

(2015) Stephen Meairs   Pharmaceutics

Ultrasound-mediated blood–brain barrier disruption for targeted drug delivery in the central nervous system

(2014) Muna Aryal et al.   ADVANCED DRUG DELIVERY REVIEWS

Coupling Mechanism and Significance of the BOLD Signal: A Status Report

(2014) Elizabeth M.C. Hillman   Annual Review of Neuroscience

Transporters at CNS Barrier Sites: Obstacles or Opportunities for Drug Delivery?

(2014) Lucy Sanchez-Covarrubias et al.   CURRENT PHARMACEUTICAL DESIGN

Postradiation imaging changes in the CNS: how can we differentiate between treatment effect and disease progression?

(2014) Amanda J Walker et al.   Future Oncology

Nitric Oxide Synthase Inhibition with the Antipterin VAS203 Improves Outcome in Moderate and Severe Traumatic Brain Injury: A Placebo-Controlled Randomized Phase IIa Trial (NOSTRA)

(2014) John F. Stover et al.   JOURNAL OF NEUROTRAUMA

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Low Dose Cranial Irradiation-Induced Cerebrovascular Damage Is Reversible in Mice

(2014) Nikolett Sándor et al.   PLoS One

Disruption of astrocyte–vascular coupling and the blood–brain barrier by invading glioma cells

(2014) Stacey Watkins et al.   Nature Communications

A Critical Role for the Vascular Endothelium in Functional Neurovascular Coupling in the Brain

(2014) Brenda R. Chen et al.   Journal of the American Heart Association

SOD Therapeutics: Latest Insights into Their Structure-Activity Relationships and Impact on the Cellular Redox-Based Signaling Pathways

(2013) Ines Batinic-Haberle et al.   ANTIOXIDANTS & REDOX SIGNALING

Krüppel-Like Factor 4 Regulates Blood-Tumor Barrier Permeability via ZO-1, Occludin and Claudin-5

(2013) Jun Ma et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases

(2013) Frits Thorsen et al.   JOURNAL OF CONTROLLED RELEASE

Pericyte loss influences Alzheimer-like neurodegeneration in mice

(2013) Abhay P. Sagare et al.   Nature Communications

Cerebral Edema

(2012) Mai-Lan Ho et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Anti-VEGF/VEGFR Therapy for Cancer: Reassessing the Target

(2012) B. Sitohy et al.   CANCER RESEARCH

The Blood-Brain Barrier: Its Influence in the Treatment of Brain Tumors Metastases

(2012) D. Fortin   CURRENT CANCER DRUG TARGETS

Attributes of brain metastases from breast and lung cancer

(2012) Kyle Hengel et al.   International Journal of Clinical Oncology

Drug Transport across the Blood–Brain Barrier

(2012) William M Pardridge   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease

(2012) Azeb Tadesse Argaw et al.   JOURNAL OF CLINICAL INVESTIGATION

Design, Mechanism of Action, Bioavailability and Therapeutic Effects of Mn Porphyrin-Based Redox Modulators

(2012) Artak Tovmasyan et al.   MEDICAL PRINCIPLES AND PRACTICE

Serum tight-junction proteins predict hemorrhagic transformation in ischemic stroke patients

(2012) R. Kazmierski et al.   NEUROLOGY

Up-regulation of P-glycoprotein is involved in the increased paclitaxel resistance in human esophageal cancer radioresistant cells

(2012) Yan Wang et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Oxidative Stress and Blood–Brain Barrier Dysfunction Under Particular Consideration of Matrix Metalloproteinases

(2011) Christine Lehner et al.   ANTIOXIDANTS & REDOX SIGNALING

Radiation-induced blood–brain barrier damages: An in vitro study

(2011) William Fauquette et al.   BRAIN RESEARCH

Inhibition of vascular endothelial growth factor (VEGF) is sufficient to completely restore barrier malfunction induced by growth factors in microvascular retinal endothelial cells

(2011) H. L. Deissler et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Persistent vascular normalization as an alternative goal of anti-angiogenic cancer therapy

(2011) Yasufumi Sato   CANCER SCIENCE

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics

(2011) Ines Batinic-Haberle et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipophilicity of Mn(III) N-Alkylpyridylporphyrins Dominates Their Accumulation Within Mitochondria and Therefore in Vivo Efficacy: a Mouse Study

(2011) Ivan Spasojevic et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of pericytes in angiogenesis

(2011) Domenico Ribatti et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Salinomycin, a p-glycoprotein inhibitor, sensitizes radiation-treated cancer cells by increasing DNA damage and inducing G2 arrest

(2011) Won Ki Kim et al.   INVESTIGATIONAL NEW DRUGS

Normalization of the Vasculature for Treatment of Cancer and Other Diseases

(2011) Shom Goel et al.   PHYSIOLOGICAL REVIEWS

Nitric Oxide Synthase Inhibition Enhances the Antitumor Effect of Radiation in the Treatment of Squamous Carcinoma Xenografts

(2011) Robert J. G. Cardnell et al.   PLoS One

Epidemiology of Brain Metastases

(2011) Lakshmi Nayak et al.   Current Oncology Reports

Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer

(2010) P. R. Lockman et al.   CLINICAL CANCER RESEARCH

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Regulation of P-glycoprotein and other ABC drug transporters at the blood–brain barrier

(2010) David S. Miller   TRENDS IN PHARMACOLOGICAL SCIENCES

Increased nitric oxide synthase activity is essential for electromagnetic-pulse-induced blood–retinal barrier breakdown in vivo

(2009) Lianjun Lu et al.   BRAIN RESEARCH

Disruptions of occludin and claudin-5 in brain endothelial cells in vitro and in brains of mice with acute liver failure

(2009) Feng Chen et al.   HEPATOLOGY

Radiation-Induced Astrogliosis and Blood-Brain Barrier Damage Can Be Abrogated Using Anti-TNF Treatment

(2009) Christy M. Wilson et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Occludin Phosphorylation and Ubiquitination Regulate Tight Junction Trafficking and Vascular Endothelial Growth Factor-induced Permeability

(2009) Tomoaki Murakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Uptake of ANG1005, A Novel Paclitaxel Derivative, Through the Blood-Brain Barrier into Brain and Experimental Brain Metastases of Breast Cancer

(2009) Fancy C. Thomas et al.   PHARMACEUTICAL RESEARCH

VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown

(2009) Azeb Tadesse Argaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier

(2008) Svetlana Stamatovic et al.   Current Neuropharmacology

Time-course of blood–brain barrier disruption in senescence-accelerated mouse prone 8 (SAMP8) mice

(2008) Jaume del Valle et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE