Can We Design a Nogo Receptor-Dependent Cellular Therapy to Target MS?

Cerebrospinal fluid level of Nogo receptor 1 antagonist lateral olfactory tract usher substance (LOTUS) correlates inversely with the extent of neuroinflammation

(2018) Keita Takahashi et al.   Journal of Neuroinflammation

Deficient Surveillance and Phagocytic Activity of Myeloid Cells Within Demyelinated Lesions in Ageing Mice Visualized byEx VivoLive Multiphoton Imaging

(2018) Khalil S. Rawji et al.   JOURNAL OF NEUROSCIENCE

The soluble form of LOTUS inhibits Nogo receptor-mediated signaling by interfering with the interaction between Nogo receptor type 1 and p75 neurotrophin receptor

(2018) Yutaka Kawakami et al.   JOURNAL OF NEUROSCIENCE

Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

(2018) Ludwig Kappos et al.   LANCET

Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria

(2018) Alan J Thompson et al.   LANCET NEUROLOGY

Nogo receptor expression in microglia/macrophages during experimental autoimmune encephalomyelitis progression

(2018) Steven Petratos et al.   Neural Regeneration Research

Amyloid-beta-dependent phosphorylation of collapsin response mediator protein-2 dissociates kinesin in Alzheimer's disease

(2018) Steven Petratos et al.   Neural Regeneration Research

Clinical Course of Multiple Sclerosis

(2018) Sylvia Klineova et al.   Cold Spring Harbor Perspectives in Medicine

Multiple sclerosis: The resolving lesion revealed

(2017) Cedric S. Raine   JOURNAL OF NEUROIMMUNOLOGY

Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis

(2017) Xavier Montalban et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of nitric oxide to axonal degeneration in multiple sclerosis via downregulating monocarboxylate transporter 1 in oligodendrocytes

(2017) Xiaoyi Tang et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Long-term Outcomes After Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis

(2017) Paolo A. Muraro et al.   JAMA Neurology

Nogo receptor 1 regulates Caspr distribution at axo-glial units in the central nervous system

(2017) Jae Young Lee et al.   Scientific Reports

An updated histological classification system for multiple sclerosis lesions

(2016) Tanja Kuhlmann et al.   ACTA NEUROPATHOLOGICA

Nogo-66 Restricts Synaptic Strengthening via Lingo1 and the ROCK2–Cofilin Pathway to Control Actin Dynamics

(2016) Cristina Iobbi et al.   CEREBRAL CORTEX

Nogo receptor complex expression dynamics in the inflammatory foci of central nervous system experimental autoimmune demyelination

(2016) Paschalis Theotokis et al.   Journal of Neuroinflammation

Brain trauma elicits non-canonical macrophage activation states

(2016) Charles C. Kim et al.   Journal of Neuroinflammation

Oral fingolimod in primary progressive multiple sclerosis (INFORMS): a phase 3, randomised, double-blind, placebo-controlled trial

(2016) Fred Lublin et al.   LANCET

Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial

(2016) Harold L Atkins et al.   LANCET

Axonal motor protein KIF5A and associated cargo deficits in multiple sclerosis lesional and normal-appearing white matter

(2016) K. Hares et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Nogo Receptor Signaling Restricts Adult Neural Plasticity by Limiting Synaptic AMPA Receptor Delivery

(2015) Susumu Jitsuki et al.   CEREBRAL CORTEX

Intravitreal Delivery of Human NgR-Fc Decoy Protein Regenerates Axons After Optic Nerve Crush and Protects Ganglion Cells in Glaucoma Models

(2015) X. Wang et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

High-Dose Immunosuppressive Therapy and Autologous Hematopoietic Cell Transplantation for Relapsing-Remitting Multiple Sclerosis (HALT-MS)

(2015) Richard A. Nash et al.   JAMA Neurology

Changes in Blood B Cell-Activating Factor (BAFF) Levels in Multiple Sclerosis: A Sign of Treatment Outcome

(2015) Karin Kannel et al.   PLoS One

Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions

(2014) Philip G. Nijland et al.   GLIA

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Human NgR-Fc Decoy Protein via Lumbar Intrathecal Bolus Administration Enhances Recovery from Rat Spinal Cord Contusion

(2014) Xingxing Wang et al.   JOURNAL OF NEUROTRAUMA

Axonal transport rate decreased at the onset of optic neuritis in EAE mice

(2014) Tsen-Hsuan Lin et al.   NEUROIMAGE

Pervasive Axonal Transport Deficits in Multiple Sclerosis Models

(2014) Catherine Diamante Sorbara et al.   NEURON

Axonal degeneration in multiple sclerosis: can we predict and prevent permanent disability?

(2014) Jae Young Lee et al.   Acta Neuropathologica Communications

Remyelination: The True Regeneration of the Central Nervous System

(2013) A.H. Crawford et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status

(2013) Daphne YS Vogel et al.   Journal of Neuroinflammation

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

Deletion of Nrf2 impairs functional recovery, reduces clearance of myelin debris and decreases axonal remyelination after peripheral nerve injury

(2013) Linxia Zhang et al.   NEUROBIOLOGY OF DISEASE

Anatomical Plasticity of Adult Brain Is Titrated by Nogo Receptor 1

(2013) Feras V. Akbik et al.   NEURON

Multiple Sclerosis

(2013) Jae Young Lee et al.   NEUROSCIENTIST

Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator

(2013) Shifeng Pan et al.   ACS Medicinal Chemistry Letters

The carboxyl-terminal region of Crtac1B/LOTUS acts as a functional domain in endogenous antagonism to Nogo receptor-1

(2012) Yuji Kurihara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation

(2012) Steven Petratos et al.   BRAIN

The role of Nogo-A in axonal plasticity, regrowth and repair

(2012) Vincent Pernet et al.   CELL AND TISSUE RESEARCH

Intrinsic axonal degeneration pathways are critical for glaucomatous damage

(2012) Gareth R. Howell et al.   EXPERIMENTAL NEUROLOGY

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

Association between pathological and MRI findings in multiple sclerosis

(2012) Massimo Filippi et al.   LANCET NEUROLOGY

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Recovery from chronic spinal cord contusion after nogo receptor intervention

(2011) Xingxing Wang et al.   ANNALS OF NEUROLOGY

Pathology of Demyelinating Diseases

(2011) Bogdan F.Gh. Popescu et al.   Annual Review of Pathology-Mechanisms of Disease

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

(2011) Ivana Nikić et al.   NATURE MEDICINE

Cartilage Acidic Protein-1B (LOTUS), an Endogenous Nogo Receptor Antagonist for Axon Tract Formation

(2011) Y. Sato et al.   SCIENCE

Demyelination versus remyelination in progressive multiple sclerosis

(2010) Stephan Bramow et al.   BRAIN

Novel Therapeutic Targets for Axonal Degeneration in Multiple Sclerosis

(2010) Steven Petratos et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Endogenous antibodies promote rapid myelin clearance and effective axon regeneration after nerve injury

(2010) M. E. Vargas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rituximab in patients with primary progressive multiple sclerosis: Results of a randomized double-blind placebo-controlled multicenter trial

(2009) Kathleen Hawker et al.   ANNALS OF NEUROLOGY

Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling

(2009) Alexandra S. Baer et al.   BRAIN

Autologous hematopoietic stem cell transplantation for autoimmune diseases: an observational study on 12 years' experience from the European Group for Blood and Marrow Transplantation Working Party on Autoimmune Diseases

(2009) D. Farge et al.   HAEMATOLOGICA

Blockade of Nogo Receptor Ligands Promotes Functional Regeneration of Sensory Axons after Dorsal Root Crush

(2009) P. A. Harvey et al.   JOURNAL OF NEUROSCIENCE

Kif1b is essential for mRNA localization in oligodendrocytes and development of myelinated axons

(2009) David A Lyons et al.   NATURE GENETICS

Oral fingolimod (FTY720) in multiple sclerosis: Two-year results of a phase II extension study

(2009) P. O'Connor et al.   NEUROLOGY

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

(2008) Bruce D. Trapp et al.   Annual Review of Neuroscience

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

Synaptic Function for the Nogo-66 Receptor NgR1: Regulation of Dendritic Spine Morphology and Activity-Dependent Synaptic Strength

(2008) H. Lee et al.   JOURNAL OF NEUROSCIENCE

Autologous haematopoietic stem-cell transplantation in multiple sclerosis

(2008) Gianluigi Mancardi et al.   LANCET NEUROLOGY

Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

(2008) Yurii S Aulchenko et al.   NATURE GENETICS

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis

(2008) Manuel A Friese et al.   NATURE MEDICINE

Incidental MRI anomalies suggestive of multiple sclerosis: The radiologically isolated syndrome

(2008) D. T. Okuda et al.   NEUROLOGY

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Axonal growth therapeutics: regeneration or sprouting or plasticity?

(2008) William B.J. Cafferty et al.   TRENDS IN NEUROSCIENCES