Polygala saponins inhibit NLRP3 inflammasome-mediated neuroinflammation via SHP-2-Mediated mitophagy
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Title
Polygala saponins inhibit NLRP3 inflammasome-mediated neuroinflammation via SHP-2-Mediated mitophagy
Authors
Keywords
NLRP3 inflammasome, Neurodegenerative disease, Mitophagy, SHP-2, Radix polygalae, Polygala saponins
Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 179, Issue -, Pages 76-94
Publisher
Elsevier BV
Online
2021-12-20
DOI
10.1016/j.freeradbiomed.2021.12.263
References
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Note: Only part of the references are listed.- NLRP3 inflammasome in cancer and metabolic diseases
- (2021) Bhesh Raj Sharma et al. NATURE IMMUNOLOGY
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- High-throughput screening for amyloid-β binding natural small-molecules based on the combinational use of biolayer interferometry and UHPLC−DAD-Q/TOF-MS/MS
- (2021) Minsong Guo et al. Acta Pharmaceutica Sinica B
- Kaixinsan, a Well-Known Chinese Herbal Prescription, for Alzheimer's Disease and Depression: A Preclinical Systematic Review
- (2020) Huan Fu et al. Frontiers in Neuroscience
- Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells
- (2020) Yueshan Sun et al. Frontiers in Pharmacology
- Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease
- (2020) Shi-Yu Chen et al. Frontiers in Pharmacology
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- (2020) Yan Gao et al. BIOCHEMICAL PHARMACOLOGY
- Lychee seed polyphenol inhibits Aβ-induced activation of NLRP3 inflammasome via the LRP1/AMPK mediated autophagy induction
- (2020) Wen-Qiao Qiu et al. BIOMEDICINE & PHARMACOTHERAPY
- Sepsis and Cerebral Dysfunction: BBB Damage, Neuroinflammation, Oxidative Stress, Apoptosis and Autophagy as Key Mediators and the Potential Therapeutic Approaches
- (2020) Ming Gu et al. NEUROTOXICITY RESEARCH
- Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases
- (2020) An-Guo Wu et al. AGEING RESEARCH REVIEWS
- Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
- (2020) Hyuk Sung Kwon et al. Translational Neurodegeneration
- The New Application of UHPLC-DAD-TOF/MS in Identification of Inhibitors on β-Amyloid Fibrillation From Scutellaria baicalensis
- (2019) Lu Yu et al. Frontiers in Pharmacology
- Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo
- (2019) Ilie-Cosmin Stancu et al. ACTA NEUROPATHOLOGICA
- Polyphyllin VI, a saponin from Trillium tschonoskii Maxim. induces apoptotic and autophagic cell death via the ROS triggered mTOR signaling pathway in non-small cell lung cancer
- (2019) Jin-Feng Teng et al. PHARMACOLOGICAL RESEARCH
- Neuroinflammation as a Common Feature of Neurodegenerative Disorders
- (2019) Leonardo Guzman-Martinez et al. Frontiers in Pharmacology
- Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease
- (2019) Jian Jing Siew et al. Nature Communications
- Targeting SHP2 as a promising strategy for cancer immunotherapy
- (2019) Qianqian Liu et al. PHARMACOLOGICAL RESEARCH
- Targeting the NLRP3 inflammasome in inflammatory diseases
- (2018) Matthew S. J. Mangan et al. NATURE REVIEWS DRUG DISCOVERY
- Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease
- (2017) Carmen Venegas et al. NATURE
- Hederagenin and α-hederin promote degradation of proteins in neurodegenerative diseases and improve motor deficits in MPTP-mice
- (2017) An-Guo Wu et al. PHARMACOLOGICAL RESEARCH
- Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis
- (2017) Wenjie Guo et al. Nature Communications
- Protein misfolding in neurodegenerative diseases: implications and strategies
- (2017) Patrick Sweeney et al. Translational Neurodegeneration
- Polygalasaponin XXXII, a triterpenoid saponin from Polygalae Radix, attenuates scopolamine-induced cognitive impairments in mice
- (2016) Heng Zhou et al. ACTA PHARMACOLOGICA SINICA
- Inflammasomes: mechanism of action, role in disease and therapeutics
- (2015) Haitao Guo et al. NATURE MEDICINE
- Indirect identification of antioxidants in Polygalae Radix through their reaction with 2,2-diphenyl-1-picrylhydrazyl and subsequent HPLC–ESI-Q-TOF-MS/MS
- (2015) Qiyuan Shi et al. TALANTA
- Identification of novel autophagic Radix Polygalae fraction by cell membrane chromatography and UHPLC-(Q)TOF-MS for degradation of neurodegenerative disease proteins
- (2015) An-Guo Wu et al. Scientific Reports
- Mitochondrial homeostasis: The interplay between mitophagy and mitochondrial biogenesis
- (2014) Konstantinos Palikaras et al. EXPERIMENTAL GERONTOLOGY
- Preclinical Evidence of Rapid-Onset Antidepressant-Like Effect in Radix Polygalae Extract
- (2014) Im-Joon Shin et al. PLoS One
- Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits
- (2014) Yujun Hou et al. PLoS One
- The discovery of Yuanzhi-1, a triterpenoid saponin derived from the traditional Chinese medicine, has antidepressant-like activity
- (2014) Zeng-liang Jin et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Onjisaponin B Derived from Radix Polygalae Enhances Autophagy and Accelerates the Degradation of Mutant α-Synuclein and Huntingtin in PC-12 Cells
- (2013) An-Guo Wu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A representative prescription for emotional disease, Ding-Zhi-Xiao-Wan restores 5-HT system deficit through interfering the synthesis and transshipment in chronic mild stress-induced depressive rats
- (2013) Xian-Zhe Dong et al. JOURNAL OF ETHNOPHARMACOLOGY
- Review: Microglia in protein aggregation disorders: friend or foe?
- (2013) S. M. Gentleman NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Xanthones from Polygala karensium inhibit neuraminidases from influenza A viruses
- (2012) Trong Tuan Dao et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Novel Role for SHP-2 in Nutrient-Responsive Control of S6 Kinase 1 Signaling
- (2012) F. Mercan et al. MOLECULAR AND CELLULAR BIOLOGY
- Anti-inflammatory effects of Polygala tenuifolia root through inhibition of NF-κB activation in lipopolysaccharide-induced BV2 microglial cells
- (2011) Myung-Hee Cheong et al. JOURNAL OF ETHNOPHARMACOLOGY
- Signaling by ROS drives inflammasome activation
- (2010) Fabio Martinon EUROPEAN JOURNAL OF IMMUNOLOGY
- Protein Misfolding and Neurodegeneration
- (2008) Claudio Soto et al. ARCHIVES OF NEUROLOGY
- Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling
- (2008) Adrienne M. Gorman JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
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