Polygala saponins inhibit NLRP3 inflammasome-mediated neuroinflammation via SHP-2-Mediated mitophagy
出版年份 2021 全文链接
标题
Polygala saponins inhibit NLRP3 inflammasome-mediated neuroinflammation via SHP-2-Mediated mitophagy
作者
关键词
NLRP3 inflammasome, Neurodegenerative disease, Mitophagy, SHP-2, Radix polygalae, Polygala saponins
出版物
FREE RADICAL BIOLOGY AND MEDICINE
Volume 179, Issue -, Pages 76-94
出版商
Elsevier BV
发表日期
2021-12-20
DOI
10.1016/j.freeradbiomed.2021.12.263
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- NLRP3 inflammasome in cancer and metabolic diseases
- (2021) Bhesh Raj Sharma et al. NATURE IMMUNOLOGY
- Enhanced mPGES-1 Contributes to PD-Related Peritoneal Fibrosis via Activation of the NLRP3 Inflammasome
- (2021) Qimei Luo et al. Frontiers in Medicine
- Saponins isolated from Radix polygalae extent lifespan by modulating complement C3 and gut microbiota
- (2021) Wu Zeng et al. PHARMACOLOGICAL RESEARCH
- Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy
- (2021) Xiaojuan Han et al. Redox Biology
- High-throughput screening for amyloid-β binding natural small-molecules based on the combinational use of biolayer interferometry and UHPLC−DAD-Q/TOF-MS/MS
- (2021) Minsong Guo et al. Acta Pharmaceutica Sinica B
- Kaixinsan, a Well-Known Chinese Herbal Prescription, for Alzheimer's Disease and Depression: A Preclinical Systematic Review
- (2020) Huan Fu et al. Frontiers in Neuroscience
- Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells
- (2020) Yueshan Sun et al. Frontiers in Pharmacology
- Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease
- (2020) Shi-Yu Chen et al. Frontiers in Pharmacology
- Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1/Parkin signaling pathway
- (2020) Yan Gao et al. BIOCHEMICAL PHARMACOLOGY
- Lychee seed polyphenol inhibits Aβ-induced activation of NLRP3 inflammasome via the LRP1/AMPK mediated autophagy induction
- (2020) Wen-Qiao Qiu et al. BIOMEDICINE & PHARMACOTHERAPY
- Sepsis and Cerebral Dysfunction: BBB Damage, Neuroinflammation, Oxidative Stress, Apoptosis and Autophagy as Key Mediators and the Potential Therapeutic Approaches
- (2020) Ming Gu et al. NEUROTOXICITY RESEARCH
- Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases
- (2020) An-Guo Wu et al. AGEING RESEARCH REVIEWS
- Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
- (2020) Hyuk Sung Kwon et al. Translational Neurodegeneration
- The New Application of UHPLC-DAD-TOF/MS in Identification of Inhibitors on β-Amyloid Fibrillation From Scutellaria baicalensis
- (2019) Lu Yu et al. Frontiers in Pharmacology
- Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo
- (2019) Ilie-Cosmin Stancu et al. ACTA NEUROPATHOLOGICA
- Polyphyllin VI, a saponin from Trillium tschonoskii Maxim. induces apoptotic and autophagic cell death via the ROS triggered mTOR signaling pathway in non-small cell lung cancer
- (2019) Jin-Feng Teng et al. PHARMACOLOGICAL RESEARCH
- Neuroinflammation as a Common Feature of Neurodegenerative Disorders
- (2019) Leonardo Guzman-Martinez et al. Frontiers in Pharmacology
- Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease
- (2019) Jian Jing Siew et al. Nature Communications
- Targeting SHP2 as a promising strategy for cancer immunotherapy
- (2019) Qianqian Liu et al. PHARMACOLOGICAL RESEARCH
- Targeting the NLRP3 inflammasome in inflammatory diseases
- (2018) Matthew S. J. Mangan et al. NATURE REVIEWS DRUG DISCOVERY
- Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease
- (2017) Carmen Venegas et al. NATURE
- Hederagenin and α-hederin promote degradation of proteins in neurodegenerative diseases and improve motor deficits in MPTP-mice
- (2017) An-Guo Wu et al. PHARMACOLOGICAL RESEARCH
- Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis
- (2017) Wenjie Guo et al. Nature Communications
- Protein misfolding in neurodegenerative diseases: implications and strategies
- (2017) Patrick Sweeney et al. Translational Neurodegeneration
- Polygalasaponin XXXII, a triterpenoid saponin from Polygalae Radix, attenuates scopolamine-induced cognitive impairments in mice
- (2016) Heng Zhou et al. ACTA PHARMACOLOGICA SINICA
- Inflammasomes: mechanism of action, role in disease and therapeutics
- (2015) Haitao Guo et al. NATURE MEDICINE
- Indirect identification of antioxidants in Polygalae Radix through their reaction with 2,2-diphenyl-1-picrylhydrazyl and subsequent HPLC–ESI-Q-TOF-MS/MS
- (2015) Qiyuan Shi et al. TALANTA
- Identification of novel autophagic Radix Polygalae fraction by cell membrane chromatography and UHPLC-(Q)TOF-MS for degradation of neurodegenerative disease proteins
- (2015) An-Guo Wu et al. Scientific Reports
- Mitochondrial homeostasis: The interplay between mitophagy and mitochondrial biogenesis
- (2014) Konstantinos Palikaras et al. EXPERIMENTAL GERONTOLOGY
- Preclinical Evidence of Rapid-Onset Antidepressant-Like Effect in Radix Polygalae Extract
- (2014) Im-Joon Shin et al. PLoS One
- Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits
- (2014) Yujun Hou et al. PLoS One
- The discovery of Yuanzhi-1, a triterpenoid saponin derived from the traditional Chinese medicine, has antidepressant-like activity
- (2014) Zeng-liang Jin et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Onjisaponin B Derived from Radix Polygalae Enhances Autophagy and Accelerates the Degradation of Mutant α-Synuclein and Huntingtin in PC-12 Cells
- (2013) An-Guo Wu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A representative prescription for emotional disease, Ding-Zhi-Xiao-Wan restores 5-HT system deficit through interfering the synthesis and transshipment in chronic mild stress-induced depressive rats
- (2013) Xian-Zhe Dong et al. JOURNAL OF ETHNOPHARMACOLOGY
- Review: Microglia in protein aggregation disorders: friend or foe?
- (2013) S. M. Gentleman NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Xanthones from Polygala karensium inhibit neuraminidases from influenza A viruses
- (2012) Trong Tuan Dao et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Novel Role for SHP-2 in Nutrient-Responsive Control of S6 Kinase 1 Signaling
- (2012) F. Mercan et al. MOLECULAR AND CELLULAR BIOLOGY
- Anti-inflammatory effects of Polygala tenuifolia root through inhibition of NF-κB activation in lipopolysaccharide-induced BV2 microglial cells
- (2011) Myung-Hee Cheong et al. JOURNAL OF ETHNOPHARMACOLOGY
- Signaling by ROS drives inflammasome activation
- (2010) Fabio Martinon EUROPEAN JOURNAL OF IMMUNOLOGY
- Protein Misfolding and Neurodegeneration
- (2008) Claudio Soto et al. ARCHIVES OF NEUROLOGY
- Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling
- (2008) Adrienne M. Gorman JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now