Iron overload cardiomyopathy: Using the latest evidence to inform future applications

Modulating mitochondrial dynamics attenuates cardiac ischemia-reperfusion injury in prediabetic rats

(2021) Chayodom Maneechote et al.   ACTA PHARMACOLOGICA SINICA

The role of mitochondrial dynamics in cardiovascular diseases

(2020) Maurizio Forte et al.   BRITISH JOURNAL OF PHARMACOLOGY

Combined chelation with high-dose deferiprone and deferoxamine to improve survival and restore cardiac function effectively in patients with transfusion-dependent thalassemia presenting severe cardiac complications

(2020) Tzu-Yao Chuang et al.   ANNALS OF HEMATOLOGY

The Molecular Mechanisms of Iron Metabolism and Its Role in Cardiac Dysfunction and Cardioprotection

(2020) Tanya Ravingerová et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Silencing of lipocalin‐2 improves cardiomyocyte viability under iron overload conditions via decreasing mitochondrial dysfunction and apoptosis

(2020) Sirinart Kumfu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Keeping heart homeostasis in check through the balance of iron metabolism

(2019) Driton Vela   Acta Physiologica

A randomized controlled trial evaluating the effects of amlodipine on myocardial iron deposition in pediatric patients with thalassemia major

(2019) Arwa Khaled et al.   Drug Design Development and Therapy

Oral ferroportin inhibitor VIT‐2763: First‐in‐human, phase 1 study in healthy volunteers

(2019) Frank Richard et al.   AMERICAN JOURNAL OF HEMATOLOGY

Mitochondrial fusion promoter restores mitochondrial dynamics balance and ameliorates diabetic cardiomyopathy in an optic atrophy 1‐dependent way

(2019) Mingge Ding et al.   Acta Physiologica

RNAi-mediated reduction of hepatic Tmprss6 diminishes anemia and secondary iron overload in a splenectomized mouse model of β-thalassemia intermedia

(2018) Paul J. Schmidt et al.   AMERICAN JOURNAL OF HEMATOLOGY

Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes

(2018) Yuichi Baba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors

(2018) Shenglin Fang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Programmed necrosis in heart disease: Molecular mechanisms and clinical implications

(2018) Hong Zhu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondrial Division Inhibitor 1 (mdivi-1) Protects Neurons against Excitotoxicity through the Modulation of Mitochondrial Function and Intracellular Ca2+ Signaling

(2018) Asier Ruiz et al.   Frontiers in Molecular Neuroscience

A randomized, controlled study evaluating effects of amlodipine addition to chelators to reduce iron loading in patients with thalassemia major

(2017) Aziz Eghbali et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Effects of iron overload, an iron chelator and a T-Type calcium channel blocker on cardiac mitochondrial biogenesis and mitochondrial dynamics in thalassemic mice

(2017) Juthamas Khamseekaew et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A combination of an iron chelator with an antioxidant exerts greater efficacy on cardioprotection than monotherapy in iron-overload thalassemic mice

(2017) Sirinart Kumfu et al.   FREE RADICAL RESEARCH

Females Are Protected From Iron‐Overload Cardiomyopathy Independent of Iron Metabolism: Key Role of Oxidative Stress

(2017) Subhash K. Das et al.   Journal of the American Heart Association

A randomized trial of amlodipine in addition to standard chelation therapy in patients with thalassemia major

(2016) J. L. Fernandes et al.   BLOOD

Dual T-type and L-type calcium channel blocker exerts beneficial effects in attenuating cardiovascular dysfunction in iron-overloaded thalassaemic mice

(2016) Sirinart Kumfu et al.   EXPERIMENTAL PHYSIOLOGY

Clinical Experience With Deferiprone Treatment for Friedreich Ataxia

(2016) Sandra Elincx-Benizri et al.   JOURNAL OF CHILD NEUROLOGY

A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloids-β accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload

(2016) Jirapas Sripetchwandee et al.   NEUROSCIENCE

Tetrahydrocurcumin in combination with deferiprone attenuates hypertension, vascular dysfunction, baroreflex dysfunction, and oxidative stress in iron-overloaded mice

(2016) Weerapon Sangartit et al.   VASCULAR PHARMACOLOGY

Combined Iron Chelator and Antioxidant Exerted Greater Efficacy on Cardioprotection Than Monotherapy in Iron-Overloaded Rats

(2016) Suwakon Wongjaikam et al.   PLoS One

Combination therapy with aTmprss6RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of β-thalassemia intermedia

(2015) Paul J. Schmidt et al.   AMERICAN JOURNAL OF HEMATOLOGY

Effects of deferasirox-deferoxamine on myocardial and liver iron in patients with severe transfusional iron overload

(2015) Yesim Aydinok et al.   BLOOD

Combination of Tmprss6- ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermedia

(2015) C. Casu et al.   HAEMATOLOGICA

Resveratrol mediates therapeutic hepatic effects in acquired and genetic murine models of iron-overload

(2015) Subhash K. Das et al.   LIVER INTERNATIONAL

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Treatment ofβ-Thalassemia/Hemoglobin E with Antioxidant Cocktails Results in Decreased Oxidative Stress, Increased Hemoglobin Concentration, and Improvement of the Hypercoagulable State

(2015) Orn-uma Yanpanitch et al.   Oxidative Medicine and Cellular Longevity

Iron-overload injury and cardiomyopathy in acquired and genetic models is attenuated by resveratrol therapy

(2015) Subhash K. Das et al.   Scientific Reports

Combination of Tmprss6- ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermedia

(2015) C. Casu et al.   HAEMATOLOGICA

N-Acetylcysteine Supplementation Reduces Oxidative Stress and DNA Damage in Children with β-Thalassemia

(2014) Zeynep Canan Ozdemir et al.   HEMOGLOBIN

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Study of Cardioprotective Effects of Necroptosis Inhibitors on Isolated Rat Heart Subjected to Global Ischemia–Reperfusion

(2013) Yu. V. Dmitriev et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Combination of necroptosis and apoptosis inhibition enhances cardioprotection against myocardial ischemia–reperfusion injury

(2013) Shizuka Koshinuma et al.   Journal of Anesthesia

Combination therapy of deferasirox and deferoxamine shows significant improvements in markers of iron overload in a patient with β-thalassemia major and severe iron burden

(2013) Ersi Voskaridou et al.   TRANSFUSION

Role of sex steroids and sexual dimorphism on cardiac iron metabolism in iron-overload cardiomyopathy

(2013) Subhash K. Das et al.   Translational Research

THERAPEUTIC VALUE OF COMBINED THERAPY WITH DEFERASIROX AND SILYMARIN ON IRON OVERLOAD IN CHILDREN WITH BETA THALASSEMIA

(2013) Adel Abd elhaleim Hagag   Mediterranean Journal of Hematology and Infectious Diseases

Mitochondrial calcium uniporter blocker prevents cardiac mitochondrial dysfunction induced by iron overload in thalassemic mice

(2012) Sirinart Kumfu et al.   BIOMETALS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Ferric iron uptake into cardiomyocytes of β-thalassemic mice is not through calcium channels

(2012) Sirinart Kumfu et al.   DRUG AND CHEMICAL TOXICOLOGY

T-type calcium channel blockade improves survival and cardiovascular function in thalassemic mice

(2012) Sirinart Kumfu et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine

(2012) Behjat Moayedi et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Chronic Cardiorenal Failure is Correlated with Endogenous Erythropoietin Levels and Decreases in Response to Low-Dose Erythropoietin Treatment

(2012) Mireille E. Emans et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Calcium Channel Blockers

(2011) William J. Elliott et al.   Journal of Clinical Hypertension

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

(2011) Gloria C. Preza et al.   JOURNAL OF CLINICAL INVESTIGATION

Iron-Chelating Therapy for Transfusional Iron Overload

(2011) Gary M. Brittenham   NEW ENGLAND JOURNAL OF MEDICINE

SnapShot: Extrinsic Apoptosis Pathways

(2010) Inge Verbrugge et al.   CELL

Combined Therapy with Idebenone and Deferiprone in Patients with Friedreich’s Ataxia

(2010) Daniel Velasco-Sánchez et al.   CEREBELLUM

Lipocalin-2/Neutrophil Gelatinase-B Associated Lipocalin Is Strongly Induced in Hearts of Rats With Autoimmune Myocarditis and in Human Myocarditis

(2010) Limin Ding et al.   CIRCULATION JOURNAL

T-type calcium channel as a portal of iron uptake into cardiomyocytes of beta-thalassemic mice

(2010) Sirinart Kumfu et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Iron-Overload Cardiomyopathy: Pathophysiology, Diagnosis, and Treatment

(2010) Colm J. Murphy et al.   JOURNAL OF CARDIAC FAILURE

Reversal of Cardiac Iron Loading and Dysfunction in Thalassemic Mice by Curcuminoids

(2010) C. Thephinlap et al.   Medicinal Chemistry

Cell Death Mechanisms and Their Implications in Toxicology

(2010) Sten Orrenius et al.   TOXICOLOGICAL SCIENCES

Interdependence of cardiac iron and calcium in a murine model of iron overload

(2010) Maya Otto-Duessel et al.   Translational Research

Vitamin E Supplementation Reduces Oxidative Stress in Beta Thalassaemia Intermedia

(2009) W.P. Pfeifer et al.   ACTA HAEMATOLOGICA

Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure

(2009) A. Yndestad et al.   EUROPEAN HEART JOURNAL

A Case of Iron Overload Cardiomyopathy

(2009) Kazuro Sugishita et al.   International Heart Journal

Upregulation of Neutrophil Gelatinase-associated Lipocalin, NGAL/Lcn2, in β-Thalassemia Patients

(2008) Mehryar Habibi Roudkenar et al.   ARCHIVES OF MEDICAL RESEARCH

Cardiac iron across different transfusion-dependent diseases

(2008) John C. Wood   BLOOD REVIEWS

Caspase inhibitor zVAD.fmk reduces infarct size after myocardial ischaemia and reperfusion in rats but not in mice

(2008) Jan Mersmann et al.   RESUSCITATION