Mitochondrial Division Inhibitor 1 (mdivi-1) Protects Neurons against Excitotoxicity through the Modulation of Mitochondrial Function and Intracellular Ca2+ Signaling

Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model

(2017) Seung Hyun Baek et al.   JOURNAL OF NEUROSCIENCE

A mitochondrial division inhibitor, Mdivi-1, inhibits mitochondrial fragmentation and attenuates kainic acid-induced hippocampal cell death

(2016) Hwajin Kim et al.   BMC NEUROSCIENCE

Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy

(2016) Shun-ichi Yamashita et al.   JOURNAL OF CELL BIOLOGY

Molecular mechanisms of NMDA receptor-mediated excitotoxicity: implications for neuroprotective therapeutics for stroke

(2016) YuTian Wang et al.   Neural Regeneration Research

Mdivi-1 Protects Epileptic Hippocampal Neurons from Apoptosis via Inhibiting Oxidative Stress and Endoplasmic Reticulum Stress in Vitro

(2016) Nanchang Xie et al.   NEUROCHEMICAL RESEARCH

Ca2+ homeostasis and endoplasmic reticulum (ER) stress: An integrated view of calcium signaling

(2015) Joachim Krebs et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bax Regulates Neuronal Ca2+ Homeostasis

(2015) B. D'Orsi et al.   JOURNAL OF NEUROSCIENCE

Chronic Glutamate Toxicity in Neurodegenerative Diseases—What is the Evidence?

(2015) Jan Lewerenz et al.   Frontiers in Neuroscience

Amelioration of Ischemic Mitochondrial Injury and Bax-Dependent Outer Membrane Permeabilization by Mdivi-1

(2014) Yan-Xin Zhao et al.   CNS Neuroscience & Therapeutics

Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death

(2014) A. Martorell-Riera et al.   EMBO JOURNAL

Mdivi-1 Prevents Apoptosis Induced by Ischemia–Reperfusion Injury in Primary Hippocampal Cells via Inhibition of Reactive Oxygen Species–Activated Mitochondrial Pathway

(2014) Jinying Wang et al.   Journal of Stroke & Cerebrovascular Diseases

CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels

(2014) A Ruiz et al.   Cell Death & Disease

The eIF2α kinases: their structures and functions

(2013) Neysan Donnelly et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling

(2013) Clare V Logan et al.   NATURE GENETICS

Role of mitochondrial fission in neuronal injury in pilocarpine-induced epileptic rats

(2013) X. Qiu et al.   NEUROSCIENCE

A selective inhibitor of Drp1, mdivi-1, acts against cerebral ischemia/reperfusion injury via an anti-apoptotic pathway in rats

(2013) Ning Zhang et al.   NEUROSCIENCE LETTERS

Atypical mitochondrial fission upon bacterial infection

(2013) F. Stavru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

(2013) Ted Weita Lai et al.   PROGRESS IN NEUROBIOLOGY

Where the endoplasmic reticulum and the mitochondrion tie the knot: The mitochondria-associated membrane (MAM)

(2012) Arun Raturi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibition of Drp1 provides neuroprotection in vitro and in vivo

(2012) J Grohm et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

After half a century mitochondrial calcium in- and efflux machineries reveal themselves

(2011) Ilaria Drago et al.   EMBO JOURNAL

Inner-membrane proteins PMI/TMEM11 regulate mitochondrial morphogenesis independently of the DRP1/MFN fission/fusion pathways

(2011) Thomas Rival et al.   EMBO REPORTS

Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

(2011) P. Tsaytler et al.   SCIENCE

Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases

(2010) P. Hemachandra Reddy et al.   BRAIN RESEARCH REVIEWS

Different pathways lead to mitochondrial fragmentation during apoptotic and excitotoxic cell death in primary neurons

(2010) Kenneth W. Young et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Endoplasmic reticulum Ca2+ release through ryanodine and IP3 receptors contributes to neuronal excitotoxicity

(2009) Asier Ruiz et al.   CELL CALCIUM

Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

(2008) Ann Cassidy-Stone et al.   DEVELOPMENTAL CELL

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

(2008) G. M. Cereghetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA