The loss of enzymatic activity of the PHARC‐associated lipase ABHD12 results in increased phagocytosis that causes neuroinflammation

A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster

(2021) Kundan Kumar et al.   BIOCHEMISTRY

Mapping the neuroanatomy of ABHD16A–ABHD12 & lysophosphatidylserines provides new insights into the pathophysiology of the human neurological disorder PHARC

(2020) Shubham Singh et al.   BIOCHEMISTRY

The Lysophosphatidylserines—An Emerging Class of Signalling Lysophospholipids

(2020) Karthik Shanbhag et al.   JOURNAL OF MEMBRANE BIOLOGY

A chemical–genetic screen identifies ABHD12 as an oxidized-phosphatidylserine lipase

(2019) Dhanashree S. Kelkar et al.   Nature Chemical Biology

Discovery and Optimization of Selective and in Vivo Active Inhibitors of the Lysophosphatidylserine Lipase α/β-Hydrolase Domain-Containing 12 (ABHD12)

(2019) Daisuke Ogasawara et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemoproteomics of an Indole-Based Quinone Epoxide Identifies Druggable Vulnerabilities in Vancomycin-Resistant Staphylococcus aureus

(2019) Amogh Kulkarni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Functional Annotation of ABHD14B, an Orphan Serine Hydrolase Enzyme

(2019) Abinaya Rajendran et al.   BIOCHEMISTRY

Lipidomics Suggests a New Role for Ceramide Synthase in Phagocytosis

(2018) Divya Pathak et al.   ACS Chemical Biology

Automated Morphological Analysis of Microglia After Stroke

(2018) Steffanie Heindl et al.   Frontiers in Cellular Neuroscience

Biochemical characterization of the PHARC associated serine hydrolase ABHD12 reveals its preference for very long chain lipids

(2018) Alaumy Joshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efferocytosis Signaling in the Regulation of Macrophage Inflammatory Responses

(2017) Michael R. Elliott et al.   JOURNAL OF IMMUNOLOGY

Characterizing microglia activation: a spatial statistics approach to maximize information extraction

(2017) Benjamin M. Davis et al.   Scientific Reports

Dynein Clusters into Lipid Microdomains on Phagosomes to Drive Rapid Transport toward Lysosomes

(2016) Ashim Rai et al.   CELL

The life cycle of phagosomes: formation, maturation, and resolution

(2016) Roni Levin et al.   IMMUNOLOGICAL REVIEWS

Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution

(2016) Bangwei Luo et al.   Nature Communications

A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation

(2016) Andreu Viader et al.   eLife

Quantitating the cell: turning images into numbers with ImageJ

(2016) Ellen T Arena et al.   Wiley Interdisciplinary Reviews-Developmental Biology

A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells

(2015) Micah J. Niphakis et al.   CELL

The ImageJ ecosystem: An open platform for biomedical image analysis

(2015) Johannes Schindelin et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay

(2015) Siddhesh S Kamat et al.   Nature Chemical Biology

Macrophages clean up: efferocytosis and microbial control

(2013) Constance J Martin et al.   CURRENT OPINION IN MICROBIOLOGY

ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC

(2013) Jacqueline L. Blankman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Review: Activation patterns of microglia and their identification in the human brain

(2012) D. Boche et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Emerging roles for lysophosphatidylserine in resolution of inflammation

(2012) S. Courtney Frasch et al.   PROGRESS IN LIPID RESEARCH

The Cell Biology of Phagocytosis

(2011) Ronald S. Flannagan et al.   Annual Review of Pathology-Mechanisms of Disease

Mutations in ABHD12 Cause the Neurodegenerative Disease PHARC: An Inborn Error of Endocannabinoid Metabolism

(2010) Torunn Fiskerstrand et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Oxidized Phospholipids as Endogenous Pattern Recognition Ligands in Innate Immunity

(2008) Stanley L. Hazen   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH Oxidase-dependent Generation of Lysophosphatidylserine Enhances Clearance of Activated and Dying Neutrophils via G2A

(2008) S. Courtney Frasch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogen destruction versus intracellular survival: the role of lipids as phagosomal fate determinants

(2008) Benjamin E. Steinberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Phagosome maturation: going through the acid test

(2008) Jason M. Kinchen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A novel Refsum-like disorder that maps to chromosome 20

(2008) T. Fiskerstrand et al.   NEUROLOGY