The Lysophosphatidylserines—An Emerging Class of Signalling Lysophospholipids

Membrane Phospholipid Analogues as Molecular Rulers to Probe the Position of Hydrophobic Contact Point of Lysophospholipid Ligands on the Surface of G-Protein-coupled Receptor during Membrane Approach

(2020) Misa Sayama et al.   BIOCHEMISTRY

Blockade of the Lysophosphatidylserine Lipase ABHD12 Potentiates Ferroptosis in Cancer Cells

(2020) Stefan G. Kathman et al.   ACS Chemical Biology

ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease

(2020) Taka-Aki Ichu et al.   BIOCHEMISTRY

Mapping the neuroanatomy of ABHD16A–ABHD12 & lysophosphatidylserines provides new insights into the pathophysiology of the human neurological disorder PHARC

(2020) Shubham Singh et al.   BIOCHEMISTRY

Genetic Study in a Large Cohort Supported Different Pathogenesis of Graves’ Disease and Hashimoto’s Hypothyroidism

(2020) Qian-Yue Zhang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Candidate gene associations reveal sex‐specific Graves’ disease risk alleles among Chinese Han populations

(2020) Chen‐Yan Yan et al.   Molecular Genetics & Genomic Medicine

A chemical–genetic screen identifies ABHD12 as an oxidized-phosphatidylserine lipase

(2019) Dhanashree S. Kelkar et al.   Nature Chemical Biology

Discovery and Optimization of Selective and in Vivo Active Inhibitors of the Lysophosphatidylserine Lipase α/β-Hydrolase Domain-Containing 12 (ABHD12)

(2019) Daisuke Ogasawara et al.   JOURNAL OF MEDICINAL CHEMISTRY

GPR34 in spinal microglia exacerbates neuropathic pain in mice

(2019) Akira Sayo et al.   Journal of Neuroinflammation

A GPR174–CCL21 module imparts sexual dimorphism to humoral immunity

(2019) Ruozhu Zhao et al.   NATURE

Lipidomics Suggests a New Role for Ceramide Synthase in Phagocytosis

(2018) Divya Pathak et al.   ACS Chemical Biology

Lysophosphatidylserine receptor P2Y10: A G protein-coupled receptor that mediates eosinophil degranulation

(2018) S. M. Hwang et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Lysophosphatidylserine suppression of T-cell activation via GPR174 requires Gαs proteins

(2018) Michael J Barnes et al.   IMMUNOLOGY AND CELL BIOLOGY

Gαs-coupled GPCRs GPR65 and GPR174. Downers for immune responses

(2018) Remy Robert et al.   IMMUNOLOGY AND CELL BIOLOGY

Synthesis of Phosphatidylserine and Its Stereoisomers: Their Role in Activation of Blood Coagulation

(2018) Suman Mallik et al.   ACS Medicinal Chemistry Letters

Biochemical characterization of the PHARC associated serine hydrolase ABHD12 reveals its preference for very long chain lipids

(2018) Alaumy Joshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo

(2018) Daisuke Ogasawara et al.   Nature Chemical Biology

Discovery of 12-Thiazole Abietanes as Selective Inhibitors of the Human Metabolic Serine Hydrolase hABHD16A

(2018) Tiina J. Ahonen et al.   ACS Medicinal Chemistry Letters

Transforming Growth Factor-β Signaling in Regulatory T Cells Controls T Helper-17 Cells and Tissue-Specific Immune Responses

(2017) Joanne E. Konkel et al.   IMMUNITY

Efferocytosis Signaling in the Regulation of Macrophage Inflammatory Responses

(2017) Michael R. Elliott et al.   JOURNAL OF IMMUNOLOGY

Probing the Hydrophobic Binding Pocket of G-Protein-Coupled Lysophosphatidylserine Receptor GPR34/LPS1 by Docking-Aided Structure–Activity Analysis

(2017) Misa Sayama et al.   JOURNAL OF MEDICINAL CHEMISTRY

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet

(2016) Bo Wang et al.   Cell Metabolism

Novel ABHD12 Mutations in PHARC Patients

(2015) Hidekane Yoshimura et al.   ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY

Combining cross-metathesis and activity-based protein profiling: New β-lactone motifs for targeting serine hydrolases

(2015) Kaddy Camara et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

G-protein Coupled Receptor 34 Knockdown Impairs the Proliferation and Migration of HGC-27 Gastric Cancer Cells In Vitro

(2015) Wei-Dong Yu et al.   CHINESE MEDICAL JOURNAL

Role of the X-Linked GeneGPR174in Autoimmune Addison's Disease

(2015) C. Napier et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function

(2015) Michael J. Barnes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structure–Activity Relationships of Lysophosphatidylserine Analogs as Agonists of G-Protein-Coupled Receptors GPR34, P2Y10, and GPR174

(2015) Masaya Ikubo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay

(2015) Siddhesh S Kamat et al.   Nature Chemical Biology

BioGPS: building your own mash-up of gene annotations and expression profiles

(2015) Chunlei Wu et al.   NUCLEIC ACIDS RESEARCH

Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion

(2015) Xin Rong et al.   eLife

Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport

(2015) Tomomi Hashidate-Yoshida et al.   eLife

Altered microglial phagocytosis in GPR34-deficient mice

(2014) Julia Preissler et al.   GLIA

Lysophosphatidylserine analogues differentially activate three LysoPS receptors

(2014) A. Uwamizu et al.   JOURNAL OF BIOCHEMISTRY

Inborn errors of metabolism in the biosynthesis and remodelling of phospholipids

(2014) Saskia B. Wortmann et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS/MS

(2014) Michiyo Okudaira et al.   JOURNAL OF LIPID RESEARCH

Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells

(2014) Daisuke Hishikawa et al.   JOURNAL OF LIPID RESEARCH

G-protein coupled receptor 34 activates Erk and phosphatidylinositol 3-kinase/Akt pathways and functions as alternative pathway to mediate p185Bcr–Abl-induced transformation and leukemogenesis

(2014) Bo Zuo et al.   LEUKEMIA & LYMPHOMA

Exome Sequencing Extends the Phenotypic Spectrum for ABHD12 Mutations

(2014) Koji M. Nishiguchi et al.   OPHTHALMOLOGY

Biochemical and Pharmacological Characterization of the Human Lymphocyte Antigen B-Associated Transcript 5 (BAT5/ABHD16A)

(2014) Juha R. Savinainen et al.   PLoS One

Phospholipid Synthesis and Transport in Mammalian Cells

(2014) Jean E. Vance   TRAFFIC

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Sphingosine-1-Phosphate and Its Receptors: Structure, Signaling, and Influence

(2013) Hugh Rosen et al.   Annual Review of Biochemistry

Mammalian alpha beta hydrolase domain (ABHD) proteins: Lipid metabolizing enzymes at the interface of cell signaling and energy metabolism

(2013) Caleb C. Lord et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

LXRs Regulate ER Stress and Inflammation through Dynamic Modulation of Membrane Phospholipid Composition

(2013) Xin Rong et al.   Cell Metabolism

Macrophages clean up: efferocytosis and microbial control

(2013) Constance J Martin et al.   CURRENT OPINION IN MICROBIOLOGY

Polyneuropathy, hearing loss, ataxia, retinitis pigmentosa and cataracts (PHARC) screening in an Italian population

(2013) C. Criscuolo et al.   EUROPEAN JOURNAL OF NEUROLOGY

Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis

(2013) Shuang-Xia Zhao et al.   HUMAN MOLECULAR GENETICS

Two Novel Mutations inABHD12: Expansion of the Mutation Spectrum in PHARC and Assessment of Their Functional Effects

(2013) Dong-Hui Chen et al.   HUMAN MUTATION

Generation of membrane diversity by lysophospholipid acyltransferases

(2013) H. Shindou et al.   JOURNAL OF BIOCHEMISTRY

Neutrophils Regulate Tissue Neutrophilia in Inflammation via the Oxidant-modified Lipid Lysophosphatidylserine

(2013) S. Courtney Frasch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An X chromosome-wide association analysis identifies variants inGPR174as a risk factor for Graves’ disease

(2013) Xun Chu et al.   JOURNAL OF MEDICAL GENETICS

ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC

(2013) Jacqueline L. Blankman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

rs3827440, a nonsynonymous single nucleotide polymorphism withinGPR174gene in X chromosome, is associated with Graves' disease in Polish Caucasian population

(2013) K. Szymański et al.   TISSUE ANTIGENS

Structure-Function of the G Protein–Coupled Receptor Superfamily

(2012) Vsevolod Katritch et al.   Annual Review of Pharmacology and Toxicology

Expression of orphan G-protein coupled receptor GPR174 in CHO cells induced morphological changes and proliferation delay via increasing intracellular cAMP

(2012) Kazuya Sugita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position

(2012) Hajime Kitamura et al.   JOURNAL OF BIOCHEMISTRY

Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)

(2012) Dina Navia-Paldanius et al.   JOURNAL OF LIPID RESEARCH

TGFα shedding assay: an accurate and versatile method for detecting GPCR activation

(2012) Asuka Inoue et al.   NATURE METHODS

Targeted next-generation sequencing identifies a homozygous nonsense mutation in ABHD12, the gene underlying PHARC, in a family clinically diagnosed with Usher syndrome type 3

(2012) Tobias Eisenberger et al.   Orphanet Journal of Rare Diseases

Emerging roles for lysophosphatidylserine in resolution of inflammation

(2012) S. Courtney Frasch et al.   PROGRESS IN LIPID RESEARCH

The Metabolic Serine Hydrolases and Their Functions in Mammalian Physiology and Disease

(2011) Jonathan Z. Long et al.   CHEMICAL REVIEWS

Phospholipases A1

(2011) Gregory S. Richmond et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Signaling via Macrophage G2A Enhances Efferocytosis of Dying Neutrophils by Augmentation of Rac Activity

(2011) S. Courtney Frasch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in ABHD12 Cause the Neurodegenerative Disease PHARC: An Inborn Error of Endocannabinoid Metabolism

(2010) Torunn Fiskerstrand et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Altered Immune Response in Mice Deficient for the G Protein-coupled Receptor GPR34

(2010) Ines Liebscher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine 1-Phosphate Receptor Signaling

(2009) Hugh Rosen et al.   Annual Review of Biochemistry

Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis

(2009) Athena Kalyvas et al.   BRAIN

Synthesis and Evaluation of Lysophosphatidylserine Analogues as Inducers of Mast Cell Degranulation. Potent Activities of Lysophosphatidylthreonine and Its 2-Deoxy Derivative

(2009) Masazumi Iwashita et al.   JOURNAL OF MEDICINAL CHEMISTRY

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources

(2009) Chunlei Wu et al.   GENOME BIOLOGY

Lysophosphatidylserine-induced functional switch of human cytochrome P450 1A2 and 2E1 from monooxygenase to phospholipase D

(2008) Eun Yi Cho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of the orphan GPCR, P2Y10 receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor

(2008) Masanori Murakami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lysophosphatidylserine stimulates chemotactic migration in U87 human glioma cells

(2008) Sun Young Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lysophosphatidylserine regulates blood glucose by enhancing glucose transport in myotubes and adipocytes

(2008) Kyungmoo Yea et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling

(2008) Heather S. Hoover et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phospholipase A2 Biochemistry

(2008) John E. Burke et al.   CARDIOVASCULAR DRUGS AND THERAPY

Member of the membrane-boundO-acyltransferase (MBOAT) family encodes a lysophospholipid acyltransferase with broad substrate specificity

(2008) Shinji Matsuda et al.   GENES TO CELLS

Lysophospholipid Acyltransferases and Arachidonate Recycling in Human Neutrophils

(2008) Miguel A. Gijón et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH Oxidase-dependent Generation of Lysophosphatidylserine Enhances Clearance of Activated and Dying Neutrophils via G2A

(2008) S. Courtney Frasch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase A2structure/function, mechanism, and signaling

(2008) John E. Burke et al.   JOURNAL OF LIPID RESEARCH

A novel Refsum-like disorder that maps to chromosome 20

(2008) T. Fiskerstrand et al.   NEUROLOGY

Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity

(2008) D. Hishikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA