Antimalarial application of quinones: A recent update

1,4-Naphthoquinones: Some Biological Properties and Application

(2020) Dmitry Aminin et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Antiplasmodial Activity of p-Substituted Benzyl Thiazinoquinone Derivatives and Their Potential against Parasitic Infections

(2020) Marcello Casertano et al.   MOLECULES

In silico, in vitro and in vivo evaluation of natural Bignoniaceous naphthoquinones in comparison with atovaquone targeting the selection of potential antimalarial candidates

(2020) Maria Fernanda Alves do Nascimento et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Molecular mechanism of action of new 1,4-naphthoquinones tethered to 1,2,3-1H-triazoles with cytotoxic and selective effect against oral squamous cell carcinoma

(2020) Ingrid Cavalcanti Chipoline et al.   BIOORGANIC CHEMISTRY

Plasmodium falciparum : multi-drug resistance

(2019) Subhashree Rout et al.   Chemical Biology & Drug Design

Exploring the antimalarial potential of the methoxy-thiazinoquinone scaffold: Identification of a new lead candidate

(2019) Concetta Imperatore et al.   BIOORGANIC CHEMISTRY

Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells

(2019) Om P.S. Patel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Antimicrobial Evaluation of 1,4‐Naphthoquinone Derivatives as Potential Antibacterial Agents

(2019) Palanisamy Ravichandiran et al.   ChemistryOpen

Artemisinin-(Iso)Quinoline Hybrids by C-H Activation and Click Chemistry: Combating Multidrug-Resistant Malaria

(2019) Aysun Çapcı et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and biological evaluation of 2-chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinones

(2019) Emmanuel O. Olawode et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Molecular Hybridization as a Tool for Designing Multitarget Drug Candidates for Complex Diseases

(2019) Viktoriya Ivasiv et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

New dimensions in the field of antimalarial research against malaria resurgence

(2019) Anudeep K. Narula et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical, pharmacological, and genetic study

(2019) Rob W van der Pluijm et al.   LANCET INFECTIOUS DISEASES

Total Synthesis of the Antimalarial Ascidian Natural Product Albopunctatone

(2019) Glenn A. Pullella et al.   ORGANIC LETTERS

Antimalarial Properties of Dunnione Derivatives as NQO2 Substrates

(2019) Monivan Chhour et al.   MOLECULES

Synthesis and Antiplasmodial Activity of 1,2,3-Triazole-Naphthoquinone Conjugates

(2019) Oramas-Royo et al.   MOLECULES

Thiazinoquinones as New Promising Multistage Schistosomicidal Compounds Impacting Schistosoma mansoni and Egg Viability

(2019) Roberto Gimmelli et al.   ACS Infectious Diseases

Antimalarial N1,N3-Dialkyldioxonaphthoimidazoliums: Synthesis, Biological Activity, and Structure–activity Relationships

(2019) Stephen Ahenkorah et al.   ACS Medicinal Chemistry Letters

The Antifungal Activity of Naphthoquinones: An Integrative Review

(2018) DÉBORA O. FUTURO et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

Drug targets for resistant malaria: Historic to future perspectives

(2018) Sahil Kumar et al.   BIOMEDICINE & PHARMACOTHERAPY

Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin

(2018) Aysun Çapcı Karagöz et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents

(2018) Okiemute Rosa Johnson-Ajinwo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hepatoprotective effect of lawsone on rifampicin-isoniazid induced hepatotoxicity in in vitro and in vivo models

(2018) S. Sylvester Darvin et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Antimalarial naphthoquinones. Synthesis via click chemistry, in vitro activity , docking to Pf DHODH and SAR of lapachol-based compounds

(2018) Geraldo Célio Brandão et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Antimalarial Activity of Lawsone Mannich Base Derivatives

(2018) Medhi Arundhati et al.   Indian Journal of Pharmaceutical Education and Research

Antibacterial naphthoquinone derivatives targeting resistant strain Gram-negative bacteria in biofilms

(2018) Juliana S. Novais et al.   MICROBIAL PATHOGENESIS

Naphthoquinone Derivatives as Scaffold to Develop New Drugs for Tuberculosis Treatment

(2018) Priscila C. B. Halicki et al.   Frontiers in Microbiology

Humanized Mouse Models for the Study of Human Malaria Parasite Biology, Pathogenesis, and Immunity

(2018) Nana K. Minkah et al.   Frontiers in Immunology

Evidence of Artemisinin-Resistant Plasmodium falciparum Malaria in Eastern India

(2018) Sabyasachi Das et al.   NEW ENGLAND JOURNAL OF MEDICINE

Current scenario of artemisinin and its analogues for antimalarial activity

(2018) Akriti Kumari et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Natural Products and Their Mimics as Targets of Opportunity for Discovery

(2017) Stephen F. Martin   JOURNAL OF ORGANIC CHEMISTRY

Pharmacomodulation of the Antimalarial Plasmodione: Synthesis of Biaryl- and N-Arylalkylamine Analogues, Antimalarial Activities and Physicochemical Properties

(2017) Karène Urgin et al.   MOLECULES

Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic

(2017) Benjamin Blasco et al.   NATURE MEDICINE

Synthesis of Thymoquinone–Artemisinin Hybrids: New Potent Antileukemia, Antiviral, and Antimalarial Agents

(2017) Tony Fröhlich et al.   ACS Medicinal Chemistry Letters

Thymoquinone, as an anticancer molecule: from basic research to clinical investigation

(2017) Md. Asaduzzaman Khan et al.   Oncotarget

The Redox Cycler Plasmodione Is a Fast-Acting Antimalarial Lead Compound with Pronounced Activity against Sexual and Early Asexual Blood-Stage Parasites

(2016) Katharina Ehrhardt et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Design, Synthesis and Antimalarial Activity of Some New 2-Hydroxy-1,4-naphthoquinone-4-hydroxyaniline Hybrid Mannich Bases

(2016) Dipshikha Sharma et al.   ASIAN JOURNAL OF CHEMISTRY

An analysis of FDA-approved drugs: natural products and their derivatives

(2016) Eric Patridge et al.   DRUG DISCOVERY TODAY

Synthesis and antimalarial activity of quinones and structurally-related oxirane derivatives

(2016) Paula F. Carneiro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Naturally Occurring Carbazole Alkaloids from Murraya koenigii as Potential Antidiabetic Agents

(2016) Om P. S. Patel et al.   JOURNAL OF NATURAL PRODUCTS

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Anthraquinones As Pharmacological Tools and Drugs

(2016) Enas M. Malik et al.   MEDICINAL RESEARCH REVIEWS

Insecticide Resistance in African Anopheles Mosquitoes: A Worsening Situation that Needs Urgent Action to Maintain Malaria Control

(2016) Hilary Ranson et al.   TRENDS IN PARASITOLOGY

Synthetic alkyl substituted quinones oxidize membrane proteins and arrest Plasmodium falciparum growth in vitro

(2015) M Duran Lengua et al.   African Journal of Pharmacy and Pharmacology

Synthesis and evaluation of (±)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H:quinone oxidoreductase 1 (NQO1)

(2015) Jinlei Bian et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Quinine conjugates and quinine analogues as potential antimalarial agents

(2015) Rachel A. Jones et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel 1,4-naphthoquinone-based sulfonamides: Synthesis, QSAR, anticancer and antimalarial studies

(2015) Ratchanok Pingaew et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tetracyclines in malaria

(2015) Tiphaine Gaillard et al.   MALARIA JOURNAL

Direct evidence for the atovaquone action on the Plasmodium cytochrome bc 1 complex

(2015) Josephine E. Siregar et al.   PARASITOLOGY INTERNATIONAL

Marine inspired antiplasmodial thiazinoquinones: synthesis, computational studies and electrochemical assays

(2015) C. Imperatore et al.   RSC Advances

Fucoxanthin, Tetraprenylated Toluquinone and Toluhydroquinone Metabolites from Sargassum heterophyllum Inhibit the in vitro Growth of the Malaria Parasite Plasmodium falciparum

(2015) Anthonia F. Afolayan et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

Evaluation of naphthoquinones identified the acetylated isolapachol as a potent and selective antiplasmodium agent

(2014) Diogo R. M. Moreira et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

2-Chloro-1,4-naphthoquinone derivative of quercetin as an inhibitor of aldose reductase and anti-inflammatory agent

(2014) Ivana Milackova et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

(2014) Xiaoyi Deng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Blood shizonticidal activities of phenazines and naphthoquinoidal compounds against Plasmodium falciparum in vitro and in mice malaria studies

(2014) Nicolli Bellotti de Souza et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Antiplasmodial anthraquinones and hemisynthetic derivatives from the leaves of Tectona grandis (Verbenaceae)

(2014) Theodora K. Kopa et al.   Phytochemistry Letters

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

(2014) J. Straimer et al.   SCIENCE

Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action

(2014) Dominic Birth et al.   Nature Communications

Quinone compounds regulate the level of ROS production by the NADPH oxidase Nox4

(2013) Minh Vu Chuong Nguyen et al.   BIOCHEMICAL PHARMACOLOGY

Isolation of antiplasmodial anthraquinones from Kniphofia ensifolia, and synthesis and structure–activity relationships of related compounds

(2013) Yumin Dai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

In vivo antimalarial activity of novel 2-hydroxy-3-anilino-1,4-naphthoquinones obtained by epoxide ring-opening reaction

(2013) Lucas Cunha Dias de Rezende et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of novel ferrocene–naphthoquinones as antiplasmodial agents

(2013) Pedro M. García-Barrantes et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antimalarial pharmacology and therapeutics of atovaquone

(2013) G. L. Nixon et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies

(2013) Benoit Witkowski et al.   LANCET INFECTIOUS DISEASES

Biological evaluation of hydroxynaphthoquinones as anti-malarials

(2013) Desiree C Schuck et al.   MALARIA JOURNAL

Discovery and Evaluation of Thiazinoquinones as Anti-Protozoal Agents

(2013) Cary Lam et al.   Marine Drugs

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Malaria biology and disease pathogenesis: insights for new treatments

(2013) Louis H Miller et al.   NATURE MEDICINE

Synthesis and antimalarial evaluation of a screening library based on a tetrahydroanthraquinone natural product scaffold

(2012) Vanida Choomuenwai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Phosphonium lipocations as antiparasitic agents

(2012) Timothy E. Long et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anthraquinones: Analytical Techniques as a Novel Tool to Investigate on the Triggering of Biological Targets

(2012) Marcello Locatelli   CURRENT DRUG TARGETS

New quinoline-5,8-dione and hydroxynaphthoquinone derivatives inhibit a chloroquine resistant Plasmodium falciparum strain

(2012) Hidayat Hussain et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Addition of thiols to o-quinone methide: New 2-hydroxy-3-phenylsulfanylmethyl[1,4]naphthoquinones and their activity against the human malaria parasite Plasmodium falciparum (3D7)

(2012) Abhinay Sharma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc 1 Catalytic Turnover and Protein Expression

(2012) Nicholas Fisher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Albopunctatone, an Antiplasmodial Anthrone-Anthraquinone from the Australian Ascidian Didemnum albopunctatum

(2012) Anthony R. Carroll et al.   JOURNAL OF NATURAL PRODUCTS

Antibiotic and Antimalarial Quinones from Fungus-Growing Ant-Associated Pseudonocardia sp.

(2012) Gavin Carr et al.   JOURNAL OF NATURAL PRODUCTS

Anti-malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii

(2012) Rubul Mout et al.   MALARIA JOURNAL

Synthesis and biological evaluation of 1,4-naphthoquinones and quinoline-5,8-diones as antimalarial and schistosomicidal agents

(2012) Don Antoine Lanfranchi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Antimalarial and antitubercular C-glycosylated benz[α]anthraquinones from the marine-derived Streptomyces sp. BCC45596

(2012) Khomsan Supong et al.   Phytochemistry Letters

Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria

(2012) G. A. Biagini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of novel β-lactams bearing an anthraquinone moiety, and evaluation of their antimalarial activities

(2012) Aliasghar Jarrahpour et al.   TETRAHEDRON

1,4-Naphthoquinone Cations as Antiplasmodial Agents: Hydroxy-, Acyloxy-, and Alkoxy-Substituted Analogues

(2012) Xiao Lu et al.   ACS Medicinal Chemistry Letters

Thymoquinone: Potential cure for inflammatory disorders and cancer

(2011) Chern Chiuh Woo et al.   BIOCHEMICAL PHARMACOLOGY

Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: Evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO

(2011) Eduardo Coelho Cerqueira et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Artemisinin: Discovery from the Chinese Herbal Garden

(2011) Louis H. Miller et al.   CELL

Glutathione Reductase-Catalyzed Cascade of Redox Reactions To Bioactivate Potent Antimalarial 1,4-Naphthoquinones – A New Strategy to Combat Malarial Parasites

(2011) Tobias Müller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials?

(2011) Eric Guantai et al.   MALARIA JOURNAL

A new world malaria map: Plasmodium falciparum endemicity in 2010

(2011) Peter W Gething et al.   MALARIA JOURNAL

Design of anti-parasitic and anti-fungal hydroxy-naphthoquinones that are less susceptible to drug resistance

(2011) Louise M. Hughes et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Malaria vector control: from past to future

(2011) Kamaraju Raghavendra et al.   PARASITOLOGY RESEARCH

Antimalarial peroxides: advances in drug discovery and design

(2011) Rachel D. Slack et al.   MedChemComm

Quinolines and structurally related heterocycles as antimalarials

(2010) Kirandeep Kaur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Thermodynamic and kinetic considerations for the reaction of semiquinone radicals to form superoxide and hydrogen peroxide

(2010) Yang Song et al.   FREE RADICAL BIOLOGY AND MEDICINE

Transforming Rhinacanthin Analogues from Potent Anticancer Agents into Potent Antimalarial Agents

(2010) Ngampong Kongkathip et al.   JOURNAL OF MEDICINAL CHEMISTRY

Probing binding determinants in center P of the cytochrome bc1 complex using novel hydroxy-naphthoquinones

(2009) Louise M. Hughes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker

(2009) Natascha Chavain et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antiproliferative and antimalarial anthraquinones of Scutia myrtina from the Madagascar forest

(2009) Yanpeng Hou et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antimalarials from nature

(2009) Kirandeep Kaur et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antimalarial natural products of marine and freshwater origin

(2009) Karl Gademann et al.   CHEMICAL RECORD

Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents

(2009) Devdutt Chaturvedi et al.   CHEMICAL SOCIETY REVIEWS

Hybrid Drugs for Malaria

(2009) J. Walsh et al.   CURRENT PHARMACEUTICAL DESIGN

Synthesis and antimalarial activity of new atovaquone derivatives

(2009) Salomé El Hage et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives

(2009) Alcides J.M. da Silva et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

Spread and evolution of Plasmodium falciparum drug resistance

(2009) Toshihiro Mita et al.   PARASITOLOGY INTERNATIONAL

Resistance to Antimalarial Drugs: Molecular, Pharmacologic, and Clinical Considerations

(2009) Mark A Travassos et al.   PEDIATRIC RESEARCH

Electrochemical parameters and techniques in drug development, with an emphasis on quinones and related compounds

(2008) Elizabeth Anne Hillard et al.   CHEMICAL COMMUNICATIONS

Inhibition of Efflux of Quinolines as New Therapeutic Strategy in Malaria

(2008) Maud Henry et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Iron Chelators and Free Radical Scavengers in Naturally Occurring Polyhydroxylated 1,4-Naphthoquinones

(2008) Alexander V. Lebedev et al.   HEMOGLOBIN

Selection of a trioxaquine as an antimalarial drug candidate

(2008) F. Cosledan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Joziknipholones A and B: The First Dimeric Phenylanthraquinones, from the Roots ofBulbine frutescens

(2007) Gerhard Bringmann et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ferrocene Conjugates of Chloroquine and other Antimalarials: the Development of Ferroquine, a New Antimalarial

(2007) Daniel Dive et al.   ChemMedChem