Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 59, Issue 5, Pages 1914-1924Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.5b01494
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Funding
- MIUR [PRIN: 2010W2KM5L_006]
- MAECI, Ministero Affari Esteri e Cooperazione Internazionale [PGR00171]
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2,6-Dipeptidyl-anthraquinones are a promising class of nucleic acid-binding compounds that act as NC inhibitors in vitro. We designed, synthesized, and tested new series of 2,6-disubstituted-anthraquinones, which are able to bind viral nucleic acid substrates of NC. We demonstrate here that these novel derivatives interact preferentially with noncanonical structures of TAR and cTAR, stabilize their dynamics, and interfere with NC chaperone activity.
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