1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity

Shedding light on RNaseH: a promising target for hepatitis B virus (HBV)

(2019) Tiffany C. Edwards et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Ribonuclease H, an unexploited target for antiviral intervention against HIV and hepatitis B virus

(2019) Enzo Tramontano et al.   ANTIVIRAL RESEARCH

Update on Recent Developments in Small Molecular HIV-1 RNase H Inhibitors (2013-2016): Opportunities and Challenges

(2018) Xueshun Wang et al.   CURRENT MEDICINAL CHEMISTRY

Novel natural non-nucleoside inhibitors of HIV-1 reverse transcriptase identified by shape- and structure-based virtual screening techniques

(2018) Giosuè Costa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors

(2018) Serena Massari et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Natural product-inspired esters and amides of ferulic and caffeic acid as dual inhibitors of HIV-1 reverse transcriptase

(2017) Vijay P. Sonar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Role of HIV-1 Drug-Resistant Minority Variants in Treatment Failure

(2017) Natalia Stella-Ascariz et al.   JOURNAL OF INFECTIOUS DISEASES

Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity

(2017) Sanjeev Kumar V. Vernekar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficient and regioselective one-step synthesis of 7-aryl-5-methyl- and 5-aryl-7-methyl-2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivatives

(2017) Serena Massari et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Studies on Cycloheptathiophene-3-carboxamide Derivatives as Allosteric HIV-1 Ribonuclease H Inhibitors

(2016) Angela Corona et al.   ChemMedChem

Feeling Nature’s PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS)

(2016) Jonathan B. Baell   JOURNAL OF NATURAL PRODUCTS

Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors

(2016) Anna Schneider et al.   NUCLEIC ACIDS RESEARCH

HIV, Aging, and Viral Coinfections: Taking the Long View

(2016) Tamar H. Taddei et al.   Current HIV/AIDS Reports

Barriers to HIV Cure

(2016) J. Stein et al.   HLA

Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6

(2016) Angela Corona et al.   PLoS One

ZINC 15 – Ligand Discovery for Everyone

(2015) Teague Sterling et al.   Journal of Chemical Information and Modeling

A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein–Basic Protein 1 (PA-PB1) Subunits

(2015) Serena Massari et al.   JOURNAL OF MEDICINAL CHEMISTRY

From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors

(2015) Lijia Xu et al.   JOURNAL OF MICROBIOLOGY

Recent Progress in the Research of Small Molecule HIV-1 RNase H Inhibitors

(2014) Lili Cao et al.   CURRENT MEDICINAL CHEMISTRY

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

Molecular Aspects of the RT/drug Interactions. Perspective of Dual Inhibitors

(2013) Simona Distinto et al.   CURRENT PHARMACEUTICAL DESIGN

Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase

(2013) Angela Corona et al.   Future Medicinal Chemistry

Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening

(2013) Joseph D. Bauman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Investigation of Cycloheptathiophene-3-carboxamide Derivatives Targeting Influenza Virus Polymerase Assembly

(2013) Serena Massari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exploiting Drug-Resistant Enzymes as Tools To Identify Thienopyrimidinone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

(2013) Takashi Masaoka et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hypericum hircinumL. components as new single-molecule inhibitors of both HIV-1 reverse transcriptase-associated DNA polymerase and ribonuclease H activities

(2013) Francesca Esposito et al.   Pathogens and Disease

DoGSiteScorer: a web server for automatic binding site prediction, analysis and druggability assessment

(2012) A. Volkamer et al.   BIOINFORMATICS

Structural Basis of the Allosteric Inhibitor Interaction on the HIV-1 Reverse Transcriptase RNase H Domain

(2012) Martin T. Christen et al.   Chemical Biology & Drug Design

Identification of HIV-1 reverse transcriptase dual inhibitors by a combined shape-, 2D-fingerprint- and pharmacophore-based virtual screening approach

(2012) Simona Distinto et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mutagenesis of Human Immunodeficiency Virus Reverse Transcriptase p51 Subunit Defines Residues Contributing to Vinylogous Urea Inhibition of Ribonuclease H Activity

(2011) Suhman Chung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Alternative Binding Sites for Inhibitors of HIV-1 Ribonuclease H Through Comparative Analysis of Virtual Enrichment Studies

(2011) Anthony K. Felts et al.   Journal of Chemical Information and Modeling

Structure-Activity Analysis of Vinylogous Urea Inhibitors of Human Immunodeficiency Virus-Encoded Ribonuclease H

(2010) S. Chung et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Studies of Anti-HIV Transcription Inhibitor Quinolones: Identification of Potent N1-Vinyl Derivatives

(2010) Oriana Tabarrini et al.   ChemMedChem

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Understanding and managing the adverse effects of antiretroviral therapy

(2009) Trevor Hawkins   ANTIVIRAL RESEARCH

Computational Analysis of Human Immunodeficiency Virus (HIV) Type-1 Reverse Transcriptase Crystallographic Models Based on Significant Conserved Residues Found in Highly Active Antiretroviral Therapy (HAART)-Treated Patients (Supplementary Material)

(2009) Stefano Alcaro et al.   CURRENT MEDICINAL CHEMISTRY

The structural basis of allosteric regulation in proteins

(2009) Roman A. Laskowski et al.   FEBS LETTERS

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Vinylogous Ureas as a Novel Class of Inhibitors of Reverse Transcriptase-Associated Ribonuclease H Activity

(2008) Michaela Wendeler et al.   ACS Chemical Biology

Structure and Function of HIV-1 Reverse Transcriptase: Molecular Mechanisms of Polymerization and Inhibition

(2008) Stefan G. Sarafianos et al.   JOURNAL OF MOLECULAR BIOLOGY

Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later

(2008) Christophe Pannecouque et al.   Nature Protocols

Slide into Action: Dynamic Shuttling of HIV Reverse Transcriptase on Nucleic Acid Substrates

(2008) S. Liu et al.   SCIENCE