DNA damage response at telomeres boosts the transcription of SARS‐CoV‐2 receptor ACE2 during aging

Telomeres: history, health, and hallmarks of aging

(2021) Deepavali Chakravarti et al.   CELL

COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection

(2021) Stephany Beyerstedt et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection

(2021) Cornelia Blume et al.   NATURE GENETICS

Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives

(2021) Alexander Vaiserman et al.   Frontiers in Genetics

Antisense technology: an overview and prospectus

(2021) Stanley T. Crooke et al.   NATURE REVIEWS DRUG DISCOVERY

Integrated analysis of multimodal single-cell data

(2021) Yuhan Hao et al.   CELL

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

(2020) Carly G.K. Ziegler et al.   CELL

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

SARS ‐CoV‐2 receptor ACE 2 and TMPRSS 2 are primarily expressed in bronchial transient secretory cells

(2020) Soeren Lukassen et al.   EMBO JOURNAL

Expression of SARS-CoV-2 receptor ACE2 and TMPRSS2 in human primary conjunctival and pterygium cell lines and in mouse cornea

(2020) Di Ma et al.   EYE

Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults

(2020) Supinda Bunyavanich et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

Individual variation of the SARS‐CoV‐2 receptor ACE2 gene expression and regulation

(2020) Jiawei Chen et al.   AGING CELL

Understanding the age divide in COVID-19: why are children overwhelmingly spared?

(2020) K. Lingappan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Single-cell RNA Expression Profiling of ACE2, The Receptor of SARS-CoV-2

(2020) Yu Zhao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Telomeres and COVID‐19

(2020) Abraham Aviv   FASEB JOURNAL

Telomerase treatment prevents lung profibrotic pathologies associated with physiological aging

(2020) Sergio Piñeiro-Hermida et al.   JOURNAL OF CELL BIOLOGY

Estimates of the severity of coronavirus disease 2019: a model-based analysis

(2020) Robert Verity et al.   LANCET INFECTIOUS DISEASES

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

(2020)   NATURE

Determinants of telomere length across human tissues

(2020) Kathryn Demanelis et al.   SCIENCE

Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2

(2020) Yuanyuan Qiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neonatal hyperoxia enhances age-dependent expression of SARS-CoV-2 receptors in mice

(2020) Min Yee et al.   Scientific Reports

Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors

(2019) Fabio Pessina et al.   NATURE CELL BIOLOGY

Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome

(2019) Julio Aguado et al.   Nature Communications

Long-term Culture and Cloning of Primary Human Bronchial Basal Cells that Maintain Multipotent Differentiation Capacity and CFTR Channel Function

(2018) Jennifer Ruth Peters-Hall et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The impact of oxidative DNA damage and stress on telomere homeostasis

(2018) Ryan P. Barnes et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Solar UV damage to cellular DNA: from mechanisms to biological effects

(2018) Leon H. F. Mullenders   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks

(2017) Flavia Michelini et al.   NATURE CELL BIOLOGY

P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan

(2016) Marco Giorgio et al.   AGING CELL

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Spatiotemporal regulation of posttranslational modifications in the DNA damage response

(2015) N. P. Dantuma et al.   EMBO JOURNAL

Endoplasmic Reticulum Stress, Genome Damage, and Cancer

(2015) Naomi Dicks et al.   Frontiers in Oncology

Quantitative telomerase enzyme activity determination using droplet digital PCR with single cell resolution

(2014) Andrew T. Ludlow et al.   NUCLEIC ACIDS RESEARCH

A two-step mechanism for TRF2-mediated chromosome-end protection

(2013) Keiji Okamoto et al.   NATURE

A quantitative telomeric chromatin isolation protocol identifies different telomeric states

(2013) Larissa Grolimund et al.   Nature Communications

Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction

(2012) Jian Ye et al.   BMC BIOINFORMATICS

Site-specific DICER and DROSHA RNA products control the DNA-damage response

(2012) Sofia Francia et al.   NATURE

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

Pscan: finding over-represented transcription factor binding site motifs in sequences from co-regulated or co-expressed genes

(2009) Federico Zambelli et al.   NUCLEIC ACIDS RESEARCH

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics