LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy

Heparin-binding VEGFR1 variants as long-acting VEGF inhibitors for treatment of intraocular neovascular disorders

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Chronic Dicer1 deficiency promotes atrophic and neovascular outer retinal pathologies in mice

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Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis

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MOUSE RETINAL CELL ATLAS: MOLECULAR IDENTIFICATION OF OVER SIXTY AMACRINE CELL TYPES

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Cell Atlas of The Human Fovea and Peripheral Retina

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Inhibition of protein glycosylation is a novel pro-angiogenic strategy that acts via activation of stress pathways

(2020) Cuiling Zhong et al.   Nature Communications

Comparative STAT3-Regulated Gene Expression Profile in Renal Cell Carcinoma Subtypes

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Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration

(2019) Jaeryung Kim et al.   Science Advances

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VEGF in Signaling and Disease: Beyond Discovery and Development

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Pleiotropy and Specificity: Insights from the Interleukin 6 Family of Cytokines

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Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring

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Determining cell type abundance and expression from bulk tissues with digital cytometry

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The Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration

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Comprehensive Integration of Single-Cell Data

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A single-cell transcriptional roadmap for cardiopharyngeal fate diversification

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Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer

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Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration

(2019) Andrew P. Voigt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration

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Inhibition of JAK-STAT Signaling with Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells

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MEK inhibition by cobimetinib suppresses hepatocellular carcinoma and angiogenesis in vitro and in vivo

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Consensus guidelines for the use and interpretation of angiogenesis assays

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The Progression of Geographic Atrophy Secondary to Age-Related Macular Degeneration

(2018) Monika Fleckenstein et al.   OPHTHALMOLOGY

Choriocapillaris Loss in Advanced Age-Related Macular Degeneration

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Systematic Evaluation of Molecular Networks for Discovery of Disease Genes

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Evaluating changes of blood flow in retina, choroid, and outer choroid in rats in response to elevated intraocular pressure by 1300 nm swept-source OCT

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Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

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cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

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Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology

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Tyrosine kinase blocking collagen IV–derived peptide suppresses ocular neovascularization and vascular leakage

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Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis

(2017) Mei Zhou et al.   Nature Communications

Retinal Angiogenesis Regulates Astrocytic Differentiation in Neonatal Mouse Retinas by Oxygen Dependent Mechanisms

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Evidence for Pro-angiogenic Functions of VEGF-Ax

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(2016) Shahin Rafii et al.   NATURE

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(2016) Napoleone Ferrara et al.   NATURE REVIEWS DRUG DISCOVERY

EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance

(2016) C. Depner et al.   Nature Communications

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

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PIM-1 modulates cellular senescence and links IL-6 signaling to heterochromatin formation

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Sodium iodate induced retinal degeneration: new insights from an old model

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Leukemia inhibitory factor protects the lung during respiratory syncytial viral infection

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Signal transducer and activator of transcription 3 and the phosphatidylinositol 3-kinase regulatory subunits p55α and p50α regulate autophagyin vivo

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Choriocapillaris breakdown precedes retinal degeneration in age-related macular degeneration

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Molecular Signatures of Tissue-Specific Microvascular Endothelial Cell Heterogeneity in Organ Maintenance and Regeneration

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Laser-induced choroidal neovascularization model to study age-related macular degeneration in mice

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A role for endothelial cells in promoting the maturation of astrocytes through the apelin/APJ system in mice

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Biology and significance of the JAK/STAT signalling pathways

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Leukemia Inhibitory Factor Coordinates the Down-regulation of the Visual Cycle in the Retina and Retinal-pigmented Epithelium

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Leukemia Inhibitory Factor Signaling Is Required for Lung Protection during Pneumonia

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Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma

(2012) Kang Zhang et al.   NATURE REVIEWS DRUG DISCOVERY

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Comparison of choroidal and retinal endothelial cells: Characteristics and response to VEGF isoforms and anti-VEGF treatments

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Elevated membrane attack complex in human choroid with high risk complement factor H genotypes

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Stat3 controls lysosomal-mediated cell death in vivo

(2011) Peter A. Kreuzaler et al.   NATURE CELL BIOLOGY

CNTF Mediates Neurotrophic Factor Secretion and Fluid Absorption in Human Retinal Pigment Epithelium

(2011) Rong Li et al.   PLoS One

Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration

(2011) K. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis

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NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations

(2008) V. Serra et al.   CANCER RESEARCH

STAT3 activation protects retinal ganglion cell layer neurons in response to stress

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Age-Related Macular Degeneration

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