A switch from α‐helical to β‐strand conformation during co‐translational protein folding

Nonrefoldability is Pervasive Across the E. coli Proteome

(2021) Philip To et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synonymous codon substitutions perturb cotranslational protein folding in vivo and impair cell fitness

(2020) Ian M. Walsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cotranslational Folding of Proteins on the Ribosome

(2020) Marija Liutkute et al.   Biomolecules

How Does the Ribosome Fold the Proteome?

(2020) Anaïs M.E. Cassaignau et al.   Annual Review of Biochemistry

Cotranslational folding cooperativity of contiguous domains of α-spectrin

(2020) Grant Kemp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy

(2019) Ziao Fu et al.   Nature Communications

Co-Translational Folding Trajectory of the HemK Helical Domain

(2018) Evan Mercier et al.   BIOCHEMISTRY

Automated map sharpening by maximization of detail and connectivity

(2018) Thomas C. Terwilliger et al.   Acta Crystallographica Section D-Structural Biology

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

New tools for the analysis and validation of cryo-EM maps and atomic models

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Investigating the Effect of Chain Connectivity on the Folding of a Beta-Sheet Protein On and Off the Ribosome

(2018) Andrew P. Marsden et al.   JOURNAL OF MOLECULAR BIOLOGY

Cotranslational Folding of a Pentarepeat β-Helix Protein

(2018) Luigi Notari et al.   JOURNAL OF MOLECULAR BIOLOGY

Folding pathway of an Ig domain is conserved on and off the ribosome

(2018) Pengfei Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A small single-domain protein folds through the same pathway on and off the ribosome

(2018) Emily J. Guinn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Model-based local density sharpening of cryo-EM maps

(2017) Arjen J Jakobi et al.   eLife

The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling

(2017) Ting Su et al.   eLife

Recent developments in the CCP-EM software suite

(2017) Tom Burnley et al.   Acta Crystallographica Section D-Structural Biology

Ribosome rearrangements at the onset of translational bypassing

(2017) Xabier Agirrezabala et al.   Science Advances

Translation regulation via nascent polypeptide-mediated ribosome stalling

(2016) Daniel N Wilson et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Small protein domains fold inside the ribosome exit tunnel

(2016) Jacopo Marino et al.   FEBS LETTERS

Structural Basis for Translation Termination on a Pseudouridylated Stop Codon

(2016) Egor Svidritskiy et al.   JOURNAL OF MOLECULAR BIOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Synonymous Codons Direct Cotranslational Folding toward Different Protein Conformations

(2016) Florian Buhr et al.   MOLECULAR CELL

A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding

(2016) Lisa D Cabrita et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding

(2016) Lisa D Cabrita et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Activities of the peptidyl transferase center of ribosomes lacking protein L27

(2015) Cristina Maracci et al.   RNA

Cotranslational protein folding on the ribosome monitored in real time

(2015) W. Holtkamp et al.   SCIENCE

Mechanical force releases nascent chain-mediated ribosome arrest in vitro and in vivo

(2015) D. H. Goldman et al.   SCIENCE

Cotranslational Protein Folding inside the Ribosome Exit Tunnel

(2015) Ola B. Nilsson et al.   Cell Reports

Specific N-terminal cleavage of ribosomal protein L27 inStaphylococcus aureusand related bacteria

(2014) Erin A. Wall et al.   MOLECULAR MICROBIOLOGY

A Kinetic Safety Gate Controlling the Delivery of Unnatural Amino Acids to the Ribosome

(2013) Joerg Mittelstaet et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

A biphasic pulling force acts on transmembrane helices during translocon-mediated membrane integration

(2012) Nurzian Ismail et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

EF-P Is Essential for Rapid Synthesis of Proteins Containing Consecutive Proline Residues

(2012) L. K. Doerfel et al.   SCIENCE

Kinetic Analysis of Ribosome-bound Fluorescent Proteins Reveals an Early, Stable, Cotranslational Folding Intermediate

(2011) Devaki A. Kelkar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ribosome Modulates Nascent Protein Folding

(2011) C. M. Kaiser et al.   SCIENCE

Short-Lived α-Helical Intermediates in the Folding of β-Sheet Proteins

(2010) Eefei Chen et al.   BIOCHEMISTRY

α-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel

(2010) Shashi Bhushan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cotranslational structure acquisition of nascent polypeptides monitored by NMR spectroscopy

(2010) C. Eichmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the 70S ribosome bound to release factor 2 and a substrate analog provides insights into catalysis of peptide release

(2010) H. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stability and folding properties of a model β-sheet protein, Escherichia coli CspA

(2010) Katherine L. Reid et al.   PROTEIN SCIENCE

Tertiary interactions within the ribosomal exit tunnel

(2009) Andrey Kosolapov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transient ribosomal attenuation coordinates protein synthesis and co-translational folding

(2009) Gong Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome

(2009) Rebecca M Voorhees et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cotranslational Folding Promotes β-Helix Formation and Avoids Aggregation In Vivo

(2008) Michael S. Evans et al.   JOURNAL OF MOLECULAR BIOLOGY

Rare Codons Cluster

(2008) Thomas F. Clarke et al.   PLoS One