Cotranslational Folding of Proteins on the Ribosome

Domain topology, stability, and translation speed determine mechanical force generation on the ribosome

(2019) Sarah E. Leininger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differences in the path to exit the ribosome across the three domains of life

(2019) Khanh Dao Duc et al.   NUCLEIC ACIDS RESEARCH

Chaperone Function of Hgh1 in the Biogenesis of Eukaryotic Elongation Factor 2

(2019) Leonie Mönkemeyer et al.   MOLECULAR CELL

The Co-chaperone Cns1 and the Recruiter Protein Hgh1 Link Hsp90 to Translation Elongation via Chaperoning Elongation Factor 2

(2019) Florian H. Schopf et al.   MOLECULAR CELL

The Ribosome Cooperates with a Chaperone to Guide Multi-domain Protein Folding

(2019) Kaixian Liu et al.   MOLECULAR CELL

Force-Profile Analysis of the Cotranslational Folding of HemK and Filamin Domains: Comparison of Biochemical and Biophysical Folding Assays

(2019) Grant Kemp et al.   JOURNAL OF MOLECULAR BIOLOGY

Co-translational assembly of mammalian nuclear multisubunit complexes

(2019) Ivanka Kamenova et al.   Nature Communications

Non-equilibrium dynamics of a nascent polypeptide during translation suppress its misfolding

(2019) Lisa M. Alexander et al.   Nature Communications

Sequence and structural patterns detected in entangled proteins reveal the importance of co-translational folding

(2019) Marco Baiesi et al.   Scientific Reports

Ribosome pausing, a dangerous necessity for co-translational events

(2019) Martine A Collart et al.   NUCLEIC ACIDS RESEARCH

Energetic dependencies dictate folding mechanism in a complex protein

(2019) Kaixian Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Benefits of Cotranslational Assembly: A Structural Perspective

(2019) Andre Schwarz et al.   TRENDS IN CELL BIOLOGY

Co-translational control of protein complex formation: a fundamental pathway of cellular organization?

(2018) Neal K. Williams et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Co-Translational Folding Trajectory of the HemK Helical Domain

(2018) Evan Mercier et al.   BIOCHEMISTRY

Co-translational Folding Intermediate Dictates Membrane Targeting of the Signal Recognition Particle Receptor

(2018) Amihai Karniel et al.   JOURNAL OF MOLECULAR BIOLOGY

The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy

(2018) Dimitra Athanasiou et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Kinetic and structural comparison of a protein’s cotranslational folding and refolding pathways

(2018) Avi J. Samelson et al.   Science Advances

Charge Interactions Can Dominate Coupled Folding and Binding on the Ribosome

(2018) Jacopo Marino et al.   BIOPHYSICAL JOURNAL

Protein Knotting by Active Threading of Nascent Polypeptide Chain Exiting From the Ribosome Exit Channel

(2018) Pawel Dabrowski-Tumanski et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structural Origins of FRET-Observed Nascent Chain Compaction on the Ribosome

(2018) Daniel A. Nissley et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling

(2018) Ayala Shiber et al.   NATURE

Effects of protein size, thermodynamic stability, and net charge on cotranslational folding on the ribosome

(2018) José Arcadio Farías-Rico et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis

(2018) Christopher A. Waudby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Cotranslational Maturation of Newly Synthesized Proteins

(2018) Günter Kramer et al.   Annual Review of Biochemistry

The stop and go traffic regulating protein biogenesis: how translation kinetics control proteostasis

(2018) Kevin C. Stein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Investigating the Effect of Chain Connectivity on the Folding of a Beta-Sheet Protein On and Off the Ribosome

(2018) Andrew P. Marsden et al.   JOURNAL OF MOLECULAR BIOLOGY

Cotranslational Folding of a Pentarepeat β-Helix Protein

(2018) Luigi Notari et al.   JOURNAL OF MOLECULAR BIOLOGY

Folding pathway of an Ig domain is conserved on and off the ribosome

(2018) Pengfei Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A small single-domain protein folds through the same pathway on and off the ribosome

(2018) Emily J. Guinn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transmembrane but not soluble helices fold inside the ribosome tunnel

(2018) Manuel Bañó-Polo et al.   Nature Communications

The shape of the bacterial ribosome exit tunnel affects cotranslational protein folding

(2018) Renuka Kudva et al.   eLife

Cotranslational folding of spectrin domains via partially structured states

(2017) Ola B Nilsson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Translation and folding of single proteins in real time

(2017) Florian Wruck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ribosome destabilizes native and non-native structures in a nascent multidomain protein

(2017) Kaixian Liu et al.   PROTEIN SCIENCE

Cotranslational folding of spectrin domains via partially structured states

(2017) Ola B Nilsson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling

(2017) Ting Su et al.   eLife

Ribosome rearrangements at the onset of translational bypassing

(2017) Xabier Agirrezabala et al.   Science Advances

Protein misfolding in neurodegenerative diseases: implications and strategies

(2017) Patrick Sweeney et al.   Translational Neurodegeneration

Translation regulation via nascent polypeptide-mediated ribosome stalling

(2016) Daniel N Wilson et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Small protein domains fold inside the ribosome exit tunnel

(2016) Jacopo Marino et al.   FEBS LETTERS

Synonymous Codons Direct Cotranslational Folding toward Different Protein Conformations

(2016) Florian Buhr et al.   MOLECULAR CELL

A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding

(2016) Lisa D Cabrita et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Not5-dependent co-translational assembly of Ada2 and Spt20 is essential for functional integrity of SAGA

(2016) Sari Kassem et al.   NUCLEIC ACIDS RESEARCH

Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor

(2016) Annika Deckert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Folding and assembly of the large molecular machine Hsp90 studied in single-molecule experiments

(2016) Markus Jahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative determination of ribosome nascent chain stability

(2016) Avi J. Samelson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased ribosome density associated to positively charged residues is evident in ribosome profiling experiments performed in the absence of translation inhibitors

(2016) Rodrigo D. Requião et al.   RNA Biology

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding

(2016) Lisa D Cabrita et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Operon Gene Order Is Optimized for Ordered Protein Complex Assembly

(2016) Jonathan N. Wells et al.   Cell Reports

Structural analysis of a signal peptide inside the ribosome tunnel by DNP MAS NMR

(2016) S. Lange et al.   Science Advances

Structural studies of the N-terminal fragments of the WW domain: Insights into co-translational folding of a beta-sheet protein

(2016) Yuya Hanazono et al.   Scientific Reports

Spatially Organized Aggregation of Misfolded Proteins as Cellular Stress Defense Strategy

(2015) Stephanie B.M. Miller et al.   JOURNAL OF MOLECULAR BIOLOGY

Operon structure and cotranslational subunit association direct protein assembly in bacteria

(2015) Y.-W. Shieh et al.   SCIENCE

Translational tuning optimizes nascent protein folding in cells

(2015) S. J. Kim et al.   SCIENCE

Cotranslational protein folding on the ribosome monitored in real time

(2015) W. Holtkamp et al.   SCIENCE

Mechanical force releases nascent chain-mediated ribosome arrest in vitro and in vivo

(2015) D. H. Goldman et al.   SCIENCE

Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stalling

(2015) Daniel Sohmen et al.   Nature Communications

Cotranslational Protein Folding inside the Ribosome Exit Tunnel

(2015) Ola B. Nilsson et al.   Cell Reports

Mechanisms of ribosome stalling by SecM at multiple elongation steps

(2015) Jun Zhang et al.   eLife

Understanding the Influence of Codon Translation Rates on Cotranslational Protein Folding

(2014) Edward P. O’Brien et al.   ACCOUNTS OF CHEMICAL RESEARCH

Intrinsically Disordered Proteins and Intrinsically Disordered Protein Regions

(2014) Christopher J. Oldfield et al.   Annual Review of Biochemistry

Cystic fibrosis genetics: from molecular understanding to clinical application

(2014) Garry R. Cutting   NATURE REVIEWS GENETICS

Molecular Basis for the Ribosome Functioning as an L-Tryptophan Sensor

(2014) Lukas Bischoff et al.   Cell Reports

Electrostatic Effect of the Ribosomal Surface on Nascent Polypeptide Dynamics

(2013) Anders M. Knight et al.   ACS Chemical Biology

Arrest Peptides:Cis-Acting Modulators of Translation

(2013) Koreaki Ito et al.   Annual Review of Biochemistry

Structural and energetic determinants of co-translational folding

(2013) Heinrich Krobath et al.   JOURNAL OF CHEMICAL PHYSICS

Transmembrane Segments Form Tertiary Hairpins in the Folding Vestibule of the Ribosome

(2013) LiWei Tu et al.   JOURNAL OF MOLECULAR BIOLOGY

Huntington's disease: underlying molecular mechanisms and emerging concepts

(2013) John Labbadia et al.   TRENDS IN BIOCHEMICAL SCIENCES

Positively Charged Residues Are the Major Determinants of Ribosomal Velocity

(2013) Catherine A. Charneski et al.   PLOS BIOLOGY

A biphasic pulling force acts on transmembrane helices during translocon-mediated membrane integration

(2012) Nurzian Ismail et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Monitoring cotranslational protein folding in mammalian cells at codon resolution

(2012) Y. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Golden triangle for folding rates of globular proteins

(2012) S. O. Garbuzynskiy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome

(2012) P. Ciryam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The genetic and molecular basis of congenital cataract

(2011) Alessandro Santana et al.   ARQUIVOS BRASILEIROS DE OFTALMOLOGIA

Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes

(2011) Nicholas T. Ingolia et al.   CELL

Kinetic Analysis of Ribosome-bound Fluorescent Proteins Reveals an Early, Stable, Cotranslational Folding Intermediate

(2011) Devaki A. Kelkar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Scenarios of Protein Folding Can Occur on the Ribosome

(2011) Edward P. O’Brien et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-Driven Vectorial Folding of Ribosome-Bound Human CFTR NBD1

(2011) Amardeep Khushoo et al.   MOLECULAR CELL

The Ribosome Modulates Nascent Protein Folding

(2011) C. M. Kaiser et al.   SCIENCE

Widespread Cotranslational Formation of Protein Complexes

(2011) Caia D. S. Duncan et al.   PLoS Genetics

Transient Tertiary Structure Formation within the Ribosome Exit Port

(2010) Edward P. O’Brien et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Consensus of Core Protein Complex Compositions for Saccharomyces cerevisiae

(2010) Joris J. Benschop et al.   MOLECULAR CELL

Structural Basis for Translational Stalling by Human Cytomegalovirus and Fungal Arginine Attenuator Peptide

(2010) Shashi Bhushan et al.   MOLECULAR CELL

α-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel

(2010) Shashi Bhushan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cotranslational structure acquisition of nascent polypeptides monitored by NMR spectroscopy

(2010) C. Eichmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-Bulk-Like Solvent Behavior in the Ribosome Exit Tunnel

(2010) Del Lucent et al.   PLoS Computational Biology

Cotranslational assembly of the yeast SET1C histone methyltransferase complex

(2009) André Halbach et al.   EMBO JOURNAL

Tertiary interactions within the ribosomal exit tunnel

(2009) Andrey Kosolapov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transient ribosomal attenuation coordinates protein synthesis and co-translational folding

(2009) Gong Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cotranslational Folding Promotes β-Helix Formation and Avoids Aggregation In Vivo

(2008) Michael S. Evans et al.   JOURNAL OF MOLECULAR BIOLOGY

Electrostatics in the Ribosomal Tunnel Modulate Chain Elongation Rates

(2008) Jianli Lu et al.   JOURNAL OF MOLECULAR BIOLOGY

A pause for thought along the co-translational folding pathway

(2008) Anton A. Komar   TRENDS IN BIOCHEMICAL SCIENCES

Protein folding: Then and now

(2007) Yiwen Chen et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS