Vascular thiol isomerases: Structures, regulatory mechanisms, and inhibitor development

Thiol isomerases orchestrate thrombosis and haemostasis

(2021) Renato Simoes Gaspar et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative Cysteine Modification of Thiol Isomerases in Thrombotic Disease: A Hypothesis

(2021) Moua Yang et al.   ANTIOXIDANTS & REDOX SIGNALING

Myricetin, the Main Flavonoid in Syzygium cumini Leaf, Is a Novel Inhibitor of Platelet Thiol Isomerases PDI and ERp5

(2020) Renato Simões Gaspar et al.   Frontiers in Pharmacology

Protein disulfide isomerase in cardiovascular disease

(2020) Bei Xiong et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Vascular thiol isomerases in thrombosis: The Yin and Yang

(2020) Yi Wu et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Zafirlukast is a broad‐spectrum thiol isomerase inhibitor that inhibits thrombosis without altering bleeding times

(2020) Lisa‐Marie Holbrook et al.   BRITISH JOURNAL OF PHARMACOLOGY

Juglone prevents human platelet aggregation through inhibiting Akt and protein disulfide isomerase

(2020) Ching-Chieh Kao et al.   PHYTOMEDICINE

TMX1: a new vascular thiol isomerase

(2019) Philip J. Hogg   BLOOD

Platelet Protein Disulfide Isomerase Promotes Glycoprotein Ibα-Mediated Platelet-Neutrophil Interactions Under Thromboinflammatory Conditions

(2019) Jing Li et al.   CIRCULATION

Allosteric disulfides: Sophisticated molecular structures enabling flexible protein regulation

(2019) Joyce Chiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Protein Disulfide Isomerase Family: from proteostasis to pathogenesis

(2019) Motonori Matsusaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Acid sphingomyelinase plays a critical role in LPS- and cytokine-induced tissue factor procoagulant activity

(2019) Jue Wang et al.   BLOOD

The crystal structure of human microsomal triglyceride transfer protein

(2019) Ekaterina I. Biterova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

von Willebrand Factor and Platelet Glycoprotein Ib: A Thromboinflammatory Axis in Stroke

(2019) Frederik Denorme et al.   Frontiers in Immunology

Tissue Factor

(2018) Steven P. Grover et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Multiple protein disulfide isomerases support thrombosis

(2018) David W. Essex et al.   CURRENT OPINION IN HEMATOLOGY

Discovery of a Novel ERp57 Inhibitor as Antiplatelet Agent from Danshen (Salvia miltiorrhiza)

(2018) Jia Zou et al.   Evidence-based Complementary and Alternative Medicine

A humanized monoclonal antibody that inhibits platelet-surface ERp72 reveals a role for ERp72 in thrombosis

(2018) L.-M. Holbrook et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The intersection of protein disulfide isomerase and cancer associated thrombosis

(2018) Jack D. Stopa et al.   THROMBOSIS RESEARCH

An update on factor XI structure and function

(2018) Bassem M. Mohammed et al.   THROMBOSIS RESEARCH

Regulatory role of thiol isomerases in thrombus formation

(2018) Anish Sharda et al.   Expert Review of Hematology

Mechano-redox control of integrin de-adhesion

(2018) Freda Passam et al.   eLife

Autoregulation of von Willebrand factor function by a disulfide bond switch

(2018) Diego Butera et al.   Science Advances

The transmembrane protein disulfide isomerase TMX1 negatively regulates platelet responses

(2018) Zhenzhen Zhao et al.   BLOOD

The b′ domain of protein disulfide isomerase cooperates with the a and a′ domains to functionally interact with platelets

(2018) Lu Wang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Kinetic-based trapping by intervening sequence variants of the active sites of protein-disulfide isomerase identifies platelet protein substrates

(2017) Jack D. Stopa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel antiplatelet role for a protein disulfide isomerase-targeted peptide: evidence of covalent binding to the C-terminal CGHC redox motif

(2017) H. R. Sousa et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structure of the human MHC-I peptide-loading complex

(2017) Andreas Blees et al.   NATURE

Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation

(2017) Sheryl R. Bowley et al.   Nature Communications

Extracellular Thiol Isomerases and Their Role in Thrombus Formation

(2016) Sol Schulman et al.   ANTIOXIDANTS & REDOX SIGNALING

Vascular thiol isomerases

(2016) Robert Flaumenhaft et al.   BLOOD

An allosteric disulfide bond is involved in enhanced activation of factor XI by protein disulfide isomerase

(2016) M. Zucker et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A substrate-driven allosteric switch that enhances PDI catalytic activity

(2016) Roelof H. Bekendam et al.   Nature Communications

Force-Sensitive Autoinhibition of the von Willebrand Factor Is Mediated by Interdomain Interactions

(2015) Camilo Aponte-Santamaría et al.   BIOPHYSICAL JOURNAL

Regulation of integrins in platelets

(2015) Joel S. Bennett   BIOPOLYMERS

von Willebrand factor is dimerized by protein disulfide isomerase

(2015) Svenja Lippok et al.   BLOOD

Both platelet- and endothelial cell-derived ERp5 support thrombus formation in a laser-induced mouse model of thrombosis

(2015) F. H. Passam et al.   BLOOD

Quercetin-3-rutinoside Inhibits Protein Disulfide Isomerase by Binding to Its b′x Domain

(2015) Lin Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis

(2015) Junsong Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

αIIbβ3: structure and function

(2015) B. S. Coller   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Erratum: Corrigendum: Novel anti-thrombotic agent for modulation of protein disulfide isomerase family member ERp57 for prophylactic therapy

(2015) Guozhen Cui et al.   Scientific Reports

The disulfide isomerase ERp57 is required for fibrin depositionin vivo

(2014) J. Zhou et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Small Molecule Probe Suitable for In Situ Profiling and Inhibition of Protein Disulfide Isomerase

(2013) Jingyan Ge et al.   ACS Chemical Biology

Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice

(2013) K. Kim et al.   BLOOD

Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the  IIb 3 integrin

(2013) L. Wang et al.   BLOOD

Three-dimensional reconstruction of intact human integrin  IIb 3: new implications for activation-dependent ligand binding

(2013) W.-S. Choi et al.   BLOOD

Integrin αIIbβ3

(2013) Kamila Bledzka et al.   CIRCULATION RESEARCH

1,3,5-Triazine as a Modular Scaffold for Covalent Inhibitors with Streamlined Target Identification

(2013) Ranjan Banerjee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Encryption and decryption of tissue factor

(2013) V. M. Chen et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Protein disulfide isomerase as an antithrombotic target

(2013) Robert Flaumenhaft   TRENDS IN CARDIOVASCULAR MEDICINE

Synergistic cooperation of PDI family members in peroxiredoxin 4-driven oxidative protein folding

(2013) Yoshimi Sato et al.   Scientific Reports

Factor XI is a substrate for oxidoreductases: Enhanced activation of reduced FXI and its role in antiphospholipid syndrome thrombosis

(2012) Bill Giannakopoulos et al.   JOURNAL OF AUTOIMMUNITY

Unique Disulfide Bonds in Epidermal Growth Factor (EGF) Domains of β3 Affect Structure and Function of αIIbβ3 and αvβ3 Integrins in Different Manner

(2012) Ronit Mor-Cohen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents

(2012) Reema Jasuja et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of tissue factor coagulant activity on cell surfaces

(2012) L. V. M. RAO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The Protein Disulfide Isomerase Family: Key Players in Health and Disease

(2011) Adam M. Benham   ANTIOXIDANTS & REDOX SIGNALING

The disulfide isomerase ERp57 mediates platelet aggregation, hemostasis, and thrombosis

(2011) Y. Wu et al.   BLOOD

P2X7 receptor signaling contributes to tissue factor–dependent thrombosis in mice

(2011) Christian Furlan-Freguia et al.   JOURNAL OF CLINICAL INVESTIGATION

The platelet-surface thiol isomerase enzyme ERp57 modulates platelet function

(2011) L.-M. HOLBROOK et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Extracellular protein disulfide isomerase regulates coagulation on endothelial cells through modulation of phosphatidylserine exposure

(2010) N. I. Popescu et al.   BLOOD

A structural overview of the PDI family of proteins

(2010) Guennadi Kozlov et al.   FEBS Journal

Structure of the Catalytic a0a Fragment of the Protein Disulfide Isomerase ERp72

(2010) Guennadi Kozlov et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulation of von Willebrand factor-platelet interactions

(2010) Julie Pegon et al.   THROMBOSIS AND HAEMOSTASIS

Protein Disulfide Isomerase: A Critical Evaluation of Its Function in Disulfide Bond Formation

(2009) Feras Hatahet et al.   ANTIOXIDANTS & REDOX SIGNALING

Mapping of the ligand-binding site on the b′ domain of human PDI: interaction with peptide ligands and the x-linker region

(2009) Lee J. Byrne et al.   BIOCHEMICAL JOURNAL

Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation

(2009) Lisa-Marie Holbrook et al.   BRITISH JOURNAL OF HAEMATOLOGY

Insights into MHC Class I Peptide Loading from the Structure of the Tapasin-ERp57 Thiol Oxidoreductase Heterodimer

(2009) Gang Dong et al.   IMMUNITY

Structure of the Noncatalytic Domains and Global Fold of the Protein Disulfide Isomerase ERp72

(2009) Guennadi Kozlov et al.   STRUCTURE

Redox Control of Platelet Function

(2008) David W. Essex   ANTIOXIDANTS & REDOX SIGNALING

A possible biochemical link between NADPH oxidase (Nox) 1 redox-signalling and ERp72

(2008) Wei Chen et al.   BIOCHEMICAL JOURNAL