Protein disulfide isomerase in cardiovascular disease

Redox Activation of Nox1 (NADPH Oxidase 1) Involves an Intermolecular Disulfide Bond Between Protein Disulfide Isomerase and p47 phox in Vascular Smooth Muscle Cells

(2019) Marcela Gimenez et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet Protein Disulfide Isomerase Promotes Glycoprotein Ibα-Mediated Platelet-Neutrophil Interactions Under Thromboinflammatory Conditions

(2019) Jing Li et al.   CIRCULATION

Allosteric disulfides: Sophisticated molecular structures enabling flexible protein regulation

(2019) Joyce Chiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Protein Disulfide Isomerase Family: from proteostasis to pathogenesis

(2019) Motonori Matsusaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Discovery and Mechanistic Elucidation of a Class of Protein Disulfide Isomerase Inhibitors for the Treatment of Glioblastoma

(2018) Anahita Kyani et al.   ChemMedChem

Multiple protein disulfide isomerases support thrombosis

(2018) David W. Essex et al.   CURRENT OPINION IN HEMATOLOGY

Inhibition of protein disulfide isomerase induces differentiation of acute myeloid leukemia cells

(2018) Justyna Chlebowska-Tuz et al.   HAEMATOLOGICA

Small molecule modulator of protein disulfide isomerase attenuates mutant huntingtin toxicity and inhibits endoplasmic reticulum stress in a mouse model of Huntington’s disease

(2018) Xiao Zhou et al.   HUMAN MOLECULAR GENETICS

Mechano-redox control of integrin de-adhesion

(2018) Freda Passam et al.   eLife

Inhibition of protein disulfide isomerase induces differentiation of acute myeloid leukemia cells

(2018) Justyna Chlebowska-Tuz et al.   HAEMATOLOGICA

Protein disulfide isomerase regulation by nitric oxide maintains vascular quiescence and controls thrombus formation

(2018) Roelof H. Bekendam et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Reactive Oxygen and Nitrogen Species–Induced Protein Modifications: Implication in Carcinogenesis and Anticancer Therapy

(2018) Nurbubu T. Moldogazieva et al.   CANCER RESEARCH

KDEL Receptors Are Differentially Regulated to Maintain the ER Proteome under Calcium Deficiency

(2018) Kathleen A. Trychta et al.   Cell Reports

Hypoxia evokes increased PDI and PDIA6 expression in the infarcted myocardium of ex-germ-free and conventionally raised mice

(2018) Klytaimnistra Kiouptsi et al.   Biology Open

Protein disulfide isomerase externalization in endothelial cells follows classical and unconventional routes

(2017) Thaís L.S. Araujo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Kinetic-based trapping by intervening sequence variants of the active sites of protein-disulfide isomerase identifies platelet protein substrates

(2017) Jack D. Stopa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein disulfide isomerase-mediated apoptosis and proliferation of vascular smooth muscle cells induced by mechanical stress and advanced glycosylation end products result in diabetic mouse vein graft atherosclerosis

(2017) Suning Ping et al.   Cell Death & Disease

Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation

(2017) Sheryl R. Bowley et al.   Nature Communications

Golgi-independent routes support protein disulfide isomerase externalization in vascular smooth muscle cells

(2017) Thaís L.S. Araujo et al.   Redox Biology

Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol IsomerasesHighlights

(2016) Marilena Crescente et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma

(2016) S. Vatolin et al.   CANCER RESEARCH

Tanshinone IIA increases levels of NeuN, protein disulfide isomerase, and Na+/K+-ATPase and decreases evidence of microglial activation after cerebral ischemic injury

(2016) Pu-Yuan Wen et al.   NEUROREPORT

A substrate-driven allosteric switch that enhances PDI catalytic activity

(2016) Roelof H. Bekendam et al.   Nature Communications

3,4-Methylenedioxy-β-nitrostyrene inhibits adhesion and migration of human triple-negative breast cancer cells by suppressing β1 integrin function and surface protein disulfide isomerase

(2015) I-Hua Chen et al.   BIOCHIMIE

Defective PDI release from platelets and endothelial cells impairs thrombus formation in Hermansky-Pudlak syndrome

(2015) A. Sharda et al.   BLOOD

Platelet–neutrophil interactions under thromboinflammatory conditions

(2015) Jing Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of Signal Transduction by Reactive Oxygen Species in the Cardiovascular System

(2015) D. I. Brown et al.   CIRCULATION RESEARCH

Quercetin-3-rutinoside Inhibits Protein Disulfide Isomerase by Binding to Its b′x Domain

(2015) Lin Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis

(2015) Junsong Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective

(2015) Anna Kaplan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Elucidation of a Small Molecule Inhibitor of Protein Disulfide Isomerase

(2015) Anna Kaplan et al.   ACS Medicinal Chemistry Letters

Control of blood proteins by functional disulfide bonds

(2014) Diego Butera et al.   BLOOD

Deregulation of Pancreas-Specific Oxidoreductin ERO1  in the Pathogenesis of Diabetes Mellitus

(2014) M. Awazawa et al.   MOLECULAR AND CELLULAR BIOLOGY

Correlation Between Attenuation of Protein Disulfide Isomerase Activity Through S-Mercuration and Neurotoxicity Induced by Methylmercury

(2014) Kento Makino et al.   NEUROTOXICITY RESEARCH

Recovery of brain biomarkers following peroxisome proliferator-activated receptor agonist neuroprotective treatment before ischemic stroke

(2014) Patrick Gelé et al.   Proteome Science

Protein disulfide isomerase a multifunctional protein with multiple physiological roles

(2014) Hyder Ali Khan et al.   Frontiers in Chemistry

Small Molecule Probe Suitable for In Situ Profiling and Inhibition of Protein Disulfide Isomerase

(2013) Jingyan Ge et al.   ACS Chemical Biology

Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice

(2013) K. Kim et al.   BLOOD

Extracellular protein disulfide isomerase regulates ligand-binding activity of  M 2 integrin and neutrophil recruitment during vascular inflammation

(2013) E. Hahm et al.   BLOOD

Platelets and Atherothrombosis: Causes, Targets and Treatments for Thrombosis

(2013) T. Siddiqui et al.   CURRENT MEDICINAL CHEMISTRY

Protein disulfide isomerase: a promising target for cancer therapy

(2013) Shili Xu et al.   DRUG DISCOVERY TODAY

Dynamic Regulation of Ero1α and Peroxiredoxin 4 Localization in the Secretory Pathway

(2013) Taichi Kakihana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein disulfide isomerase in thrombosis and vascular inflammation

(2013) J. Cho   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Protein disulfide isomerase may facilitate the efflux of nitrite derived S-nitrosothiols from red blood cells

(2013) Vasantha Madhuri Kallakunta et al.   Redox Biology

The Physiological Functions of Mammalian Endoplasmic Oxidoreductin 1: On Disulfides and More

(2012) Thomas Ramming et al.   ANTIOXIDANTS & REDOX SIGNALING

Structural Insights into the Redox-Regulated Dynamic Conformations of Human Protein Disulfide Isomerase

(2012) Chao Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein Disulfide Isomerase Modification and Inhibition Contribute to ER Stress and Apoptosis Induced by Oxidized Low Density Lipoproteins

(2012) Carole Muller et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of  3 integrins

(2012) J. Cho et al.   BLOOD

Neutrophils in acute lung injury

(2012) Xiao et al.   Frontiers in Bioscience-Landmark

Protein Disulfide Isomerase Is Required for Platelet-derived Growth Factor-induced Vascular Smooth Muscle Cell Migration, Nox1 NADPH Oxidase Expression, and RhoGTPase Activation

(2012) Luciana A. Pescatore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T granules in human platelets function in TLR9 organization and signaling

(2012) Jonathan N. Thon et al.   JOURNAL OF CELL BIOLOGY

Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents

(2012) Reema Jasuja et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment

(2012) S. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S-Glutathionylation: From Molecular Mechanisms to Health Outcomes

(2011) Ying Xiong et al.   ANTIOXIDANTS & REDOX SIGNALING

Structure, Mechanism, and Evolution of Ero1 Family Enzymes

(2011) Kazutaka Araki et al.   ANTIOXIDANTS & REDOX SIGNALING

The Protein Disulfide Isomerase Family: Key Players in Health and Disease

(2011) Adam M. Benham   ANTIOXIDANTS & REDOX SIGNALING

Protein disulfide isomerase redox-dependent association with p47phox : evidence for an organizer role in leukocyte NADPH oxidase activation

(2011) Antonio Marcus de A. Paes et al.   JOURNAL OF LEUKOCYTE BIOLOGY

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(2011) Stefano Toldo et al.   MOLECULAR MEDICINE

p-hydroxybenzyl alcohol prevents brain injury and behavioral impairment by activating Nrf2, PDI, and neurotrophic factor genes in a rat model of brain ischemia

(2011) Kyung-Yoon Kam et al.   MOLECULES AND CELLS

Discovery of a Small Molecule PDI Inhibitor That Inhibits Reduction of HIV-1 Envelope Glycoprotein gp120

(2010) Maola M. G. Khan et al.   ACS Chemical Biology

Cystine 186-cystine 209 disulfide bond is not essential for the procoagulant activity of tissue factor or for its de-encryption

(2010) H. Kothari et al.   BLOOD

Endothelium-derived but not platelet-derived protein disulfide isomerase is required for thrombus formation in vivo

(2010) R. Jasuja et al.   BLOOD

Bacitracin is not a specific inhibitor of protein disulfide isomerase

(2010) Anna-Riikka Karala et al.   FEBS Journal

Plasticity of Human Protein Disulfide Isomerase

(2010) Chao Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ero1α Is Expressed on Blood Platelets in Association with Protein-disulfide Isomerase and Contributes to Redox-controlled Remodeling of αIIbβ3

(2010) Maria Swiatkowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERO1-β, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis

(2010) Ester Zito et al.   JOURNAL OF CELL BIOLOGY

Analysis of disulfide bonds in protein structures

(2010) J. W. H. WONG et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins

(2010) Benjamin G Hoffstrom et al.   Nature Chemical Biology

Protein disulfide isomerase increases in myocardial endothelial cells in mice exposed to chronic hypoxia: a stimulatory role in angiogenesis

(2009) Fei Tian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

What Is Wrong With the Allosteric Disulfide Bond Hypothesis?

(2009) Ronald R. Bach et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inferior Vena Cava Ligation Rapidly Induces Tissue Factor Expression and Venous Thrombosis in Rats

(2009) Ji Zhou et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nitrosative Stress-Induced S-Glutathionylation of Protein Disulfide Isomerase Leads to Activation of the Unfolded Protein Response

(2009) D. M. Townsend et al.   CANCER RESEARCH

Recent trends in acute lung injury mortality: 1996–2005*

(2009) Sara E. Erickson et al.   CRITICAL CARE MEDICINE

A novel disulphide switch mechanism in Ero1α balances ER oxidation in human cells

(2008) Christian Appenzeller-Herzog et al.   EMBO JOURNAL

Alternative Conformations of the x Region of Human Protein Disulphide-Isomerase Modulate Exposure of the Substrate Binding b’ Domain

(2008) Van Dat Nguyen et al.   JOURNAL OF MOLECULAR BIOLOGY