von Willebrand Factor and Platelet Glycoprotein Ib: A Thromboinflammatory Axis in Stroke

Thromboinflammation: Challenges of Therapeutically Targeting Coagulation and other Host Defence Mechanisms

(2019) Shaun P. Jackson et al.   BLOOD

Platelet Protein Disulfide Isomerase Promotes Glycoprotein Ibα-Mediated Platelet-Neutrophil Interactions Under Thromboinflammatory Conditions

(2019) Jing Li et al.   CIRCULATION

CD69 Plays a Beneficial Role in Ischemic Stroke by Dampening Endothelial Activation

(2019) Vanessa H. Brait et al.   CIRCULATION RESEARCH

Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance

(2019) Senna Staessens et al.   HAEMATOLOGICA

Location of Neutrophils in Different Compartments of the Damaged Mouse Brain After Severe Ischemia/Reperfusion

(2019) Amaia Otxoa-de-Amezaga et al.   STROKE

Von Willebrand factor enhanced microvesicle-induced vascular leakage and coagulopathy in mice with traumatic brain injury

(2018) Yingang Wu et al.   BLOOD

Platelet glycoprotein receptor Ib blockade ameliorates experimental cerebral ischemia–reperfusion injury by strengthening the blood–brain barrier function and anti-thrombo-inflammatory property

(2018) Chunyan Chen et al.   BRAIN BEHAVIOR AND IMMUNITY

Influence of Thrombolysis on the Safety and Efficacy of Blocking Platelet Adhesion or Secretory Activity in Acute Ischemic Stroke in Mice

(2018) Michael K. Schuhmann et al.   Translational Stroke Research

Recombinant Human ADAMTS13 Treatment Improves Myocardial Remodeling and Functionality After Pressure Overload Injury in Mice

(2018) Thilo Witsch et al.   Journal of the American Heart Association

Downstream Microvascular Thrombosis in Cortical Venules Is an Early Response to Proximal Cerebral Arterial Occlusion

(2018) Jean‐Philippe Desilles et al.   Journal of the American Heart Association

The Role of von Willebrand Factor, ADAMTS13, and Cerebral Artery Thrombus Composition in Patient Outcome Following Mechanical Thrombectomy for Acute Ischemic Stroke

(2018) Vaclav Prochazka et al.   MEDICAL SCIENCE MONITOR

Elevated Factor VIII and von Willebrand Factor Levels Predict Unfavorable Outcome in Stroke Patients Treated with Intravenous Thrombolysis

(2018) Noémi Klára Tóth et al.   Frontiers in Neurology

Anfibatide protects against rat cerebral ischemia/reperfusion injury via TLR4/JNK/caspase-3 pathway

(2017) Sheng-Yong Luo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A biophysical view on von Willebrand factor activation

(2017) Achim Löf et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Blocking of platelet glycoprotein receptor Ib reduces “thrombo-inflammation” in mice with acute ischemic stroke

(2017) Michael K. Schuhmann et al.   Journal of Neuroinflammation

Genetic Drivers of von Willebrand Factor Levels in an Ischemic Stroke Population and Association With Risk for Recurrent Stroke

(2017) Stephen R. Williams et al.   STROKE

Thrombotic thrombocytopenic purpura

(2017) Johanna A. Kremer Hovinga et al.   Nature Reviews Disease Primers

Endothelial Cell–Derived von Willebrand Factor Is the Major Determinant That Mediates von Willebrand Factor–Dependent Acute Ischemic Stroke by Promoting Postischemic Thrombo-InflammationHighlights

(2016) Nirav Dhanesha et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Life in the shadow of a dominant partner: the FVIII-VWF association and its clinical implications for hemophilia A

(2016) S. W. Pipe et al.   BLOOD

ADAMTS13-mediated thrombolysis of t-PA-resistant occlusions in ischemic stroke in mice

(2016) F. Denorme et al.   BLOOD

Lifecycle of Weibel-Palade bodies

(2016) M. Mourik et al.   Hamostaseologie

Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura

(2016) Flora Peyvandi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Thromboinflammation in Stroke Brain Damage

(2016) Simon F. De Meyer et al.   STROKE

The VWF-GPIb axis in ischaemic stroke: lessons from animal models

(2016) Frederik Denorme et al.   THROMBOSIS AND HAEMOSTASIS

A genetically-engineered von Willebrand disease type 2B mouse model displays defects in hemostasis and inflammation

(2016) Frédéric Adam et al.   Scientific Reports

von Willebrand factor contributes to poor outcome in a mouse model of intracerebral haemorrhage

(2016) Ximin Zhu et al.   Scientific Reports

Low ADAMTS13 activity is associated with an increased risk of ischemic stroke

(2015) M. A. H. Sonneveld et al.   BLOOD

Platelet-derived VWF is not essential for normal thrombosis and hemostasis but fosters ischemic stroke injury in mice

(2015) S. Verhenne et al.   BLOOD

von Willebrand factor biosynthesis, secretion, and clearance: connecting the far ends

(2015) P. J. Lenting et al.   BLOOD

Delayed treatment with ADAMTS13 ameliorates cerebral ischemic injury without hemorrhagic complication

(2015) Takafumi Nakano et al.   BRAIN RESEARCH

A novel snake venom-derived GPIb antagonist, anfibatide, protects mice from acute experimental ischaemic stroke and reperfusion injury

(2015) Ting-Ting Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Relationship between ADAMTS13 activity, von Willebrand factor antigen levels and platelet function in the early and late phases after TIA or ischaemic stroke

(2015) Dominick J.H. McCabe et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Recombinant ADAMTS 13 Attenuates Brain Injury After Intracerebral Hemorrhage

(2015) Ping Cai et al.   STROKE

Efficacy and Safety of Platelet Glycoprotein Receptor Blockade in Aged and Comorbid Mice With Acute Experimental Stroke

(2015) Peter Kraft et al.   STROKE

Alteplase Reduces Downstream Microvascular Thrombosis and Improves the Benefit of Large Artery Recanalization in Stroke

(2015) Jean-Philippe Desilles et al.   STROKE

Platelets in Inflammation: Regulation of Leukocyte Activities and Vascular Repair

(2015) Angèle Gros et al.   Frontiers in Immunology

GpIb -VWF blockade restores vessel patency by dissolving platelet aggregates formed under very high shear rate in mice

(2014) A. Le Behot et al.   BLOOD

Active von Willebrand factor predicts 28-day mortality in patients with systemic inflammatory response syndrome

(2014) A. Hyseni et al.   BLOOD

von Willebrand factor, Jedi knight of the bloodstream

(2014) T. A. Springer   BLOOD

Von Willebrand factor and ADAMTS13 in arterial thrombosis: a systematic review and meta-analysis

(2014) Michelle A.H. Sonneveld et al.   BLOOD REVIEWS

Effect of ADAMTS-13 on cerebrovascular microthrombosis and neuronal injury after experimental subarachnoid hemorrhage

(2014) C. Muroi et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Effect of recombinant ADAMTS-13 on microthrombosis and brain injury after experimental subarachnoid hemorrhage

(2014) M. D. I. Vergouwen et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice

(2013) A. S. Savchenko et al.   BLOOD

Reperfusion of cerebral artery thrombosis by the GPIb-VWF blockade with the Nanobody ALX-0081 reduces brain infarct size in guinea pigs

(2013) S. Momi et al.   BLOOD

Blocking Von Willebrand Factor for Treatment of Cutaneous Inflammation

(2013) Carina Hillgruber et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Recombinant ADAMTS13 reduces tissue plasminogen activator-induced hemorrhage after stroke in mice

(2012) Lixiang Wang et al.   ANNALS OF NEUROLOGY

Unwinding the von Willebrand factor strings puzzle

(2012) K. De Ceunynck et al.   BLOOD

Protective anti-inflammatory effect of ADAMTS13 on myocardial ischemia/reperfusion injury in mice

(2012) S. F. De Meyer et al.   BLOOD

ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice

(2012) C. Gandhi et al.   BLOOD

Sequence and structure relationships within von Willebrand factor

(2012) Y.-F. Zhou et al.   BLOOD

ADAMTS13 reduces VWF-mediated acute inflammation following focal cerebral ischemia in mice

(2012) M. M. KHAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

ADAMTS13 gene deletion enhances plasma high-mobility group box1 elevation and neuroinflammation in brain ischemia–reperfusion injury

(2012) Masayuki Fujioka et al.   NEUROLOGICAL SCIENCES

Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor

(2011) J. T. B. Crawley et al.   BLOOD

ADAMTS13 reduces vascular inflammation and the development of early atherosclerosis in mice

(2011) C. Gandhi et al.   BLOOD

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

Binding of von Willebrand Factor to Collagen and Glycoprotein Ibα, But Not to Glycoprotein IIb/IIIa, Contributes to Ischemic Stroke in Mice—Brief Report

(2010) Simon F. De Meyer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

von Willebrand factor promotes leukocyte extravasation

(2010) B. Petri et al.   BLOOD

High von Willebrand Factor Levels Increase the Risk of Stroke

(2010) Renske G. Wieberdink et al.   STROKE

von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke

(2009) B.-Q. Zhao et al.   BLOOD

Deficiency of von Willebrand factor protects mice from ischemic stroke

(2009) C. Kleinschnitz et al.   BLOOD

von Willebrand factor to the rescue

(2009) S. F. De Meyer et al.   BLOOD

ADAMTS13 gene deletion aggravates ischemic brain damage: a possible neuroprotective role of ADAMTS13 by ameliorating postischemic hypoperfusion

(2009) M. Fujioka et al.   BLOOD

von Willebrand factor assembly and secretion

(2009) J. E. SADLER   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Integrin  v 3 on human endothelial cells binds von Willebrand factor strings under fluid shear stress

(2008) J. Huang et al.   BLOOD

ADAMTS13: a new link between thrombosis and inflammation

(2008) Anil K. Chauhan et al.   JOURNAL OF EXPERIMENTAL MEDICINE