Obesity and insulin resistance: Pathophysiology and treatment

Prospective association of physical activity and inflammatory biomarkers in older adults from the PREDIMED-Plus study with overweight or obesity and metabolic syndrome

(2020) Gabriela Cárdenas Fuentes et al.   CLINICAL NUTRITION

Mitochondrial dysfunction, insulin resistance and potential genetic implications

(2020) Panjamaporn Sangwung et al.   ENDOCRINOLOGY

CPT1A-mediated Fat Oxidation, Mechanisms, and Therapeutic Potential

(2020) Isabel R Schlaepfer et al.   ENDOCRINOLOGY

Quercetin attenuates adipose hypertrophy, in part through activation of adipogenesis in rats fed a high-fat diet

(2020) Diahann J. Perdicaro et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Exercise training prevents obesity/diabetes‐induced activation of inflammatory signaling in rat brown adipose tissue

(2020) Takamasa Tsuzuki et al.   FASEB JOURNAL

Adjunctive effect of the serotonin 5-HT2C receptor agonist lorcaserin on opioid-induced antinociception in mice

(2020) Salvador Sierra et al.   NEUROPHARMACOLOGY

Lipase Inhibitors for Obesity: A Review

(2020) Tian-Tian Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Hepatic Insulin Clearance: Mechanism and Physiology

(2019) Sonia M. Najjar et al.   PHYSIOLOGY

Normal Weight Obesity: An Underrecognized Problem in Individuals of South Asian Descent

(2019) Nitin Kapoor et al.   CLINICAL THERAPEUTICS

Metabolically healthy obesity: facts and fantasies

(2019) Gordon I. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Endoplasmic Reticulum Stress Activates Unfolded Protein Response Signaling and Mediates Inflammation, Obesity, and Cardiac Dysfunction: Therapeutic and Molecular Approach

(2019) Omar Mohammed Amen et al.   Frontiers in Pharmacology

Luseogliflozin attenuates neointimal hyperplasia after wire injury in high-fat diet-fed mice via inhibition of perivascular adipose tissue remodeling

(2019) Yusaku Mori et al.   Cardiovascular Diabetology

Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation

(2019) Lin-Hu Quan et al.   GUT

Effectiveness of Intermittent Fasting and Time-Restricted Feeding Compared to Continuous Energy Restriction for Weight Loss

(2019) Corey A. Rynders et al.   Nutrients

Occurence of First and Recurrent Major Adverse Cardiovascular Events With Liraglutide Treatment Among Patients With Type 2 Diabetes and High Risk of Cardiovascular Events

(2019) Subodh Verma et al.   JAMA Cardiology

Postprandial dyslipidemia, hyperinsulinemia, and impaired gut peptides/bile acids in adolescents with obesity

(2019) Victoria Higgins et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Berberine decreases insulin resistance in a PCOS rats by improving GLUT4: Dual regulation of the PI3K/AKT and MAPK pathways

(2019) Ning Zhang et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Insulin resistance in obesity: an overview of fundamental alterations

(2018) Rocco Barazzoni et al.   Eating and Weight Disorders-Studies on Anorexia Bulimia and Obesity

Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation

(2018) Daniel J. Fazakerley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin resistance causes inflammation in adipose tissue

(2018) Mitsugu Shimobayashi et al.   JOURNAL OF CLINICAL INVESTIGATION

Roles of G protein-coupled estrogen receptor GPER in metabolic regulation

(2018) Geetanjali Sharma et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Aegeline inspired synthesis of novel β3-AR agonist improves insulin sensitivity in vitro and in vivo models of insulin resistance

(2018) Sujith Rajan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Small molecules for fat combustion: targeting obesity

(2018) Jingxin Liu et al.   Acta Pharmaceutica Sinica B

Metabolically healthy versus metabolically unhealthy obesity

(2018) Carla Iacobini et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Circadian clocks and insulin resistance

(2018) Dirk Jan Stenvers et al.   Nature Reviews Endocrinology

Treatment of obesity-associated overactive bladder by the phosphodiesterase type-4 inhibitor roflumilast

(2017) Honglin Ding et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

G Protein–Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus

(2017) Darren M. Riddy et al.   PHARMACOLOGICAL REVIEWS

Neuronal systems and circuits involved in the control of food intake and adaptive thermogenesis

(2016) Alexandre Caron et al.   Annals of the New York Academy of Sciences

Imbalanced insulin action in chronic over nutrition: Clinical harm, molecular mechanisms, and a way forward

(2016) Kevin Jon Williams et al.   ATHEROSCLEROSIS

Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance?

(2016) M. Bluher   CLINICAL SCIENCE

Obesity and cancer: inflammation bridges the two

(2016) Ryan Kolb et al.   CURRENT OPINION IN PHARMACOLOGY

Association of Pharmacological Treatments for Obesity With Weight Loss and Adverse Events

(2016) Rohan Khera et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cannabidiol promotes browning in 3T3-L1 adipocytes

(2016) Hilal Ahmad Parray et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Metabolically healthy obese individuals: Key protective factors

(2016) Carolina G. Gonçalves et al.   NUTRITION

Endogenous central amygdala mu-opioid receptor signaling promotes sodium appetite in mice

(2016) Craig M. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of regular exercise on obesity and type 2 diabete mellitus in Korean children: improvements glycemic control and serum adipokines level

(2015) Sung Soo Lee et al.   Journal of Physical Therapy Science

A mathematical model of leptin resistance

(2015) Marine Jacquier et al.   MATHEMATICAL BIOSCIENCES

Metabolomics Reveals Metabolically Healthy and Unhealthy Obese Individuals Differ in their Response to a Caloric Challenge

(2015) Flavia Badoud et al.   PLoS One

UPR, autophagy, and mitochondria crosstalk underlies the ER stress response

(2015) Daniela Senft et al.   TRENDS IN BIOCHEMICAL SCIENCES

Metreleptin for injection to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy

(2015) Cristina Adelia Meehan et al.   Expert Review of Clinical Pharmacology

Resistin’s, obesity and insulin resistance: the continuing disconnect between rodents and humans

(2015) X. Huang et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Dual role of B7 costimulation in obesity-related non-alcoholic steatohepatitis (NASH) and metabolic dysregulation

(2014) A Chatzigeorgiou et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Metabolically healthy and unhealthy obese - the 2013 Stock Conference report

(2014) D. Samocha-Bonet et al.   Obesity Reviews

Metreleptin: First Global Approval

(2013) Ken Chou et al.   DRUGS

Weight Loss Strategies for Treatment of Obesity

(2013) Robert F. Kushner   PROGRESS IN CARDIOVASCULAR DISEASES

Microvascular dysfunction: An emerging pathway in the pathogenesis of obesity-related insulin resistance

(2013) Dennis M. J. Muris et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Fanconi Anemia Links Reactive Oxygen Species to Insulin Resistance and Obesity

(2012) Jie Li et al.   ANTIOXIDANTS & REDOX SIGNALING

Design, synthesis and identification of novel benzimidazole derivatives as highly potent NPY Y5 receptor antagonists with attractive in vitro ADME profiles

(2012) Yuusuke Tamura et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

(2012) Megumi Hatori et al.   Cell Metabolism

Proteasome Dysfunction Mediates Obesity-Induced Endoplasmic Reticulum Stress and Insulin Resistance in the Liver

(2012) T. Otoda et al.   DIABETES

Long-Term Safety, Tolerability, and Weight Loss Associated With Metformin in the Diabetes Prevention Program Outcomes Study

(2012)   DIABETES CARE

Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects

(2012) H Ziauddeen et al.   MOLECULAR PSYCHIATRY

Effects of novel vaccines on weight loss in diet-induced-obese (DIO) mice

(2012) Keith N Haffer   Journal of Animal Science and Biotechnology

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

ER stress is implicated in mitochondrial dysfunction-induced apoptosis of pancreatic beta cells

(2011) June Woo Lee et al.   MOLECULES AND CELLS

Obesity-associated insulin resistance in skeletal muscle: Role of lipid accumulation and physical inactivity

(2011) Kristin Eckardt et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Over-expression of NYGGF4 (PID1) inhibits glucose transport in skeletal myotubes by blocking the IRS1/PI3K/AKT insulin pathway

(2010) W.L. Wu et al.   MOLECULAR GENETICS AND METABOLISM

Weight Loss, HbA1cReduction, and Tolerability of Cetilistat in a Randomized, Placebo-controlled Phase 2 Trial in Obese Diabetics: Comparison With Orlistat (Xenical)

(2009) Peter Kopelman et al.   Obesity

Intestinal microflora and obesity in rats

(2008) Š. Mozeš et al.   FOLIA MICROBIOLOGICA

Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial

(2008) Arne Astrup et al.   LANCET