Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice

The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS

(2010) S. W. Lane et al.   BLOOD

Induction of p53 and up-regulation of the p53 pathway in the human 5q- syndrome

(2010) A. Pellagatti et al.   BLOOD

Haploinsufficiency of Apc leads to ineffective hematopoiesis

(2010) J. Wang et al.   BLOOD

Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells

(2010) A Pellagatti et al.   LEUKEMIA

Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction

(2009) M. L. Chen et al.   BLOOD

Progressive Chromatin Repression and Promoter Methylation of CTNNA1 Associated with Advanced Myeloid Malignancies

(2009) Y. Ye et al.   CANCER RESEARCH

The prognostic impact of 17p (p53) deletion in 2272 adults with acute myeloid leukemia

(2009) H Seifert et al.   LEUKEMIA

A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q– syndrome

(2009) Jillian L Barlow et al.   NATURE MEDICINE

Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype

(2009) Daniel T Starczynowski et al.   NATURE MEDICINE

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systematic molecular genetic analysis of congenital sideroblastic anemia: Evidence for genetic heterogeneity and identification of novel mutations

(2009) Anke K. Bergmann et al.   PEDIATRIC BLOOD & CANCER

Integrated Genomic Analysis Implicates Haploinsufficiency of Multiple Chromosome 5q31.2 Genes in De Novo Myelodysplastic Syndromes Pathogenesis

(2009) Timothy A. Graubert et al.   PLoS One

Chaperoning erythropoiesis

(2008) M. J. Weiss et al.   BLOOD

Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse

(2008) P. Sportoletti et al.   BLOOD

The immunophenotype of different immature, myeloid and B-cell lineage-committed CD34+ hematopoietic cells allows discrimination between normal/reactive and myelodysplastic syndrome precursors

(2008) S Matarraz et al.   LEUKEMIA

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

(2008) Benjamin L. Ebert et al.   NATURE