Engineering of regulatory T cells by means of mRNA electroporation in a GMP-compliant manner

The Ins and Outs of Messenger RNA Electroporation for Physical Gene Delivery in Immune Cell-Based Therapy

(2021) Diana Campillo-Davo et al.   Pharmaceutics

Made to Measure: Patient-Tailored Treatment of Multiple Sclerosis Using Cell-Based Therapies

(2021) Inez Wens et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Optimized CRISPR-mediated gene knockin reveals FOXP3-independent maintenance of human Treg identity

(2021) Avery J. Lam et al.   Cell Reports

Delivery of CRISPR/Cas systems for cancer gene therapy and immunotherapy

(2020) Xiangrong Song et al.   ADVANCED DRUG DELIVERY REVIEWS

CRISPR-Cas, a robust gene-editing technology in the era of modern cancer immunotherapy

(2020) Seyed Mohammad Miri et al.   Cancer Cell International

Electroporation as a method of choice to generate genetically modified dendritic cell cancer vaccines

(2020) Rita Ahmed et al.   CURRENT OPINION IN BIOTECHNOLOGY

Regulating the regulators: Is introduction of an antigen-specific approach in regulatory T cells the next step to treat autoimmunity?

(2020) Ibo Janssens et al.   CELLULAR IMMUNOLOGY

Engineered regulatory T cells expressing myelin-specific chimeric antigen receptors suppress EAE progression

(2020) Alessandra De Paula Pohl et al.   CELLULAR IMMUNOLOGY

Genetic engineering of human and mouse CD4+ and CD8+ Tregs using lentiviral vectors encoding chimeric antigen receptors

(2020) Nadège Vimond et al.   Molecular Therapy-Methods & Clinical Development

Helios+ and Helios− Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires

(2019) Angela M. Thornton et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Methods to manufacture regulatory T cells for cell therapy

(2019) Katherine N. MacDonald et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Engineered MBP-specific human Tregs ameliorate MOG-induced EAE through IL-2-triggered inhibition of effector T cells

(2018) Yong Chan Kim et al.   JOURNAL OF AUTOIMMUNITY

Targeting Antigen-Specific B Cells Using Antigen-Expressing Transduced Regulatory T Cells

(2018) Ai-Hong Zhang et al.   JOURNAL OF IMMUNOLOGY

A versatile T cell-based assay to assess therapeutic antigen-specific PD-1-targeted approaches

(2018) Maarten Versteven et al.   Oncotarget

A Phase I Clinical Trial with Ex Vivo Expanded Recipient Regulatory T cells in Living Donor Kidney Transplants

(2018) James M. Mathew et al.   Scientific Reports

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization

(2018) Anke Fuchs et al.   Frontiers in Immunology

Clinical Grade Regulatory CD4+ T Cells (Tregs): Moving Toward Cellular-Based Immunomodulatory Therapies

(2018) Richard Duggleby et al.   Frontiers in Immunology

The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases

(2018) Maria Grazia Roncarolo et al.   IMMUNITY

Regulatory T-cell therapy for autoimmune and autoinflammatory diseases: The next frontier

(2018) Jonathan H. Esensten et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Treg cells—the next frontier of cell therapy

(2018) Jeffrey A. Bluestone et al.   SCIENCE

Efficient and Non-genotoxic RNA-Based Engineering of Human T Cells Using Tumor-Specific T Cell Receptors With Minimal TCR Mispairing

(2018) Diana Campillo-Davo et al.   Frontiers in Immunology

Generation of human islet-specific regulatory T cells by TCR gene transfer

(2017) Caroline M. Hull et al.   JOURNAL OF AUTOIMMUNITY

CD45RA Distinguishes CD4+CD25+CD127−/low TSDR Demethylated Regulatory T Cell Subpopulations With Differential Stability and Susceptibility to Tacrolimus-Mediated Inhibition of Suppression

(2017) Rebeca Arroyo Hornero et al.   TRANSPLANTATION

Evading innate immunity in nonviral mRNA delivery: don’t shoot the messenger

(2016) Joke Devoldere et al.   DRUG DISCOVERY TODAY

The cytotoxic T lymphocyte immune synapse at a glance

(2016) Nele M. G. Dieckmann et al.   JOURNAL OF CELL SCIENCE

Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X

(2016) Jianle Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

(2016) C. T. Ellebrecht et al.   SCIENCE

Helios—controller of Treg stability and function

(2016) Claire Chougnet et al.   Translational Cancer Research

Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect

(2015) C. G. Brunstein et al.   BLOOD

Phenotypic Complexity of the Human Regulatory T Cell Compartment Revealed by Mass Cytometry

(2015) Gavin M. Mason et al.   JOURNAL OF IMMUNOLOGY

Cancer immunotherapy utilizing gene-modified T cells: From the bench to the clinic

(2015) Connie P.M. Duong et al.   MOLECULAR IMMUNOLOGY

Human thymus medullary epithelial cells promote regulatory T-cell generation by stimulating interleukin-2 production via ICOS ligand

(2014) D Nazzal et al.   Cell Death & Disease

The Immunological Synapse

(2014) M. L. Dustin   Cancer Immunology Research

A novel function for FOXP3 in humans: intrinsic regulation of conventional T cells

(2012) A. N. McMurchy et al.   BLOOD

Interleukin-12p70 Expression by Dendritic Cells of HIV-1-Infected Patients Fails to Stimulategag-Specific Immune Responses

(2012) Ellen Van Gulck et al.   Clinical & Developmental Immunology

CD4+CD25+CD127low/− T Cells: A More Specific Treg Population in Human Peripheral Blood

(2012) Ning Yu et al.   INFLAMMATION

The battle against immunopathology: infectious tolerance mediated by regulatory T cells

(2011) David M. Gravano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Suppression assays with human T regulatory cells: A technical guide

(2011) Alicia N. McMurchy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Massive ex Vivo Expansion of Human Natural Regulatory T Cells (Tregs) with Minimal Loss of in Vivo Functional Activity

(2011) K. L. Hippen et al.   Science Translational Medicine

Human Regulatory T Cells with Alloantigen Specificity Are More Potent Inhibitors of Alloimmune Skin Graft Damage than Polyclonal Regulatory T Cells

(2011) P. Sagoo et al.   Science Translational Medicine

Mammalian cell transfection: the present and the future

(2010) Tae Kyung Kim et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Efficient mRNA electroporation of peripheral blood mononuclear cells to detect memory T cell responses for immunomonitoring purposes

(2010) K. Van Camp et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

A role for the transcription factor Helios in human CD4+CD25+ regulatory T cells

(2010) Derese Getnet et al.   MOLECULAR IMMUNOLOGY

Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures

(2009) D. Q. Tran et al.   BLOOD

Quantitative DNA Methylation Analysis of FOXP3 as a New Method for Counting Regulatory T Cells in Peripheral Blood and Solid Tissue

(2009) G. Wieczorek et al.   CANCER RESEARCH

Loss of FOXP3 expression in natural human CD4+CD25+regulatory T cells upon repetitivein vitrostimulation

(2009) Petra Hoffmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

Regulatory T cells: how do they suppress immune responses?

(2009) S. Sakaguchi et al.   INTERNATIONAL IMMUNOLOGY

Ex vivo expansion of CD4+CD25+T regulatory cells for immunosuppressive therapy

(2008) Piotr Trzonkowski et al.   CYTOMETRY PART A