Helios+ and Helios− Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires

Immune regulatory cell infusion for graft-versus-host disease prevention and therapy

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Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR

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Transcription factor c-Rel is indispensable for generation of thymic but not of peripheral Foxp3+ regulatory T cells

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Cyclic AMP Represents a Crucial Component of Treg Cell-Mediated Immune Regulation

(2016) Matthias Klein et al.   Frontiers in Immunology

Generation of Helios reporter mice and an evaluation of the suppressive capacity of Helios+regulatory T cellsin vitro

(2015) Kazunari Sugita et al.   EXPERIMENTAL DERMATOLOGY

T-cell Receptor Sequencing Reveals the Clonal Diversity and Overlap of Colonic Effector and FOXP3+ T Cells in Ulcerative Colitis

(2015) James Lord et al.   INFLAMMATORY BOWEL DISEASES

Helios Controls a Limited Subset of Regulatory T Cell Functions

(2015) Mathew Sebastian et al.   JOURNAL OF IMMUNOLOGY

Coexpression of TIGIT and FCRL3 Identifies Helios+Human Memory Regulatory T Cells

(2015) Khalid Bin Dhuban et al.   JOURNAL OF IMMUNOLOGY

SATB1 Plays a Critical Role in Establishment of Immune Tolerance

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(2015) Daehwan Kim et al.   NATURE METHODS

Stable inhibitory activity of regulatory T cells requires the transcription factor Helios

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Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

Differences in Expression Level of Helios and Neuropilin-1 Do Not Distinguish Thymus-Derived from Extrathymically-Induced CD4+Foxp3+ Regulatory T Cells

(2015) Edyta Szurek et al.   PLoS One

HTSeq--a Python framework to work with high-throughput sequencing data

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Helios defines T cells being driven to tolerance in the periphery and thymus

(2014) Ellen M. Ross et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

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(2014) Ethan M. Shevach et al.   IMMUNOLOGICAL REVIEWS

CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

(2013) Kate S. Smigiel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Helios+ and Helios- Cells Coexist within the Natural FOXP3+ T Regulatory Cell Subset in Humans

(2013) M. E. Himmel et al.   JOURNAL OF IMMUNOLOGY

Bach2 Regulates Homeostasis of Foxp3+ Regulatory T Cells and Protects against Fatal Lung Disease in Mice

(2013) E. H. Kim et al.   JOURNAL OF IMMUNOLOGY

BACH2 represses effector programs to stabilize Treg-mediated immune homeostasis

(2013) Rahul Roychoudhuri et al.   NATURE

Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion

(2012) Y. C. Kim et al.   BLOOD

Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut

(2012) Susan M. Schlenner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phenotypic and Functional Properties of Helios+ Regulatory T Cells

(2012) Daniel J. Zabransky et al.   PLoS One

A Requisite Role for Induced Regulatory T Cells in Tolerance Based on Expanding Antigen Receptor Diversity

(2011) Dipica Haribhai et al.   IMMUNITY

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(2011) Alexander Y. Rudensky   IMMUNOLOGICAL REVIEWS

Expression of Helios in Peripherally Induced Foxp3+ Regulatory T Cells

(2011) R. A. Gottschalk et al.   JOURNAL OF IMMUNOLOGY

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(2011) Stephanie K. Lathrop et al.   NATURE

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation

(2011) Marc Beyer et al.   NATURE IMMUNOLOGY

Helios Is Associated with CD4 T Cells Differentiating to T Helper 2 and Follicular Helper T Cells In Vivo Independently of Foxp3 Expression

(2011) Karine Serre et al.   PLoS One

Helios Expression Is a Marker of T Cell Activation and Proliferation

(2011) Tatiana Akimova et al.   PLoS One

Comment on "Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells"

(2010) J. Verhagen et al.   JOURNAL OF IMMUNOLOGY

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

(2009) Maria A. Curotto de Lafaille et al.   IMMUNITY

DNA methylation controls Foxp3 gene expression

(2008) Julia K. Polansky et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Antigen-specific peripheral shaping of the natural regulatory T cell population

(2008) Stephanie K. Lathrop et al.   JOURNAL OF EXPERIMENTAL MEDICINE