Drosophilatools and assays for the study of human diseases

Of flies and men: insights on organismal metabolism from fruit flies

(2017) Akhila Rajan et al.   BMC BIOLOGY

From whole body to cellular models of hepatic triglyceride metabolism: man has got to know his limitations

(2015) Charlotte J. Green et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Morgan’s Legacy: Fruit Flies and the Functional Annotation of Conserved Genes

(2015) Hugo J. Bellen et al.   CELL

Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

(2015) Lucy Liu et al.   CELL

Pentamidine rescues contractility and rhythmicity in a Drosophila model of myotonic dystrophy heart dysfunction

(2015) M. Chakraborty et al.   Disease Models & Mechanisms

Glial expression of Swiss cheese (SWS), theDrosophilaorthologue of neuropathy target esterase (NTE), is required for neuronal ensheathment and function

(2015) Sudeshna Dutta et al.   Disease Models & Mechanisms

Fruit Flies in Biomedical Research

(2015) M. F. Wangler et al.   GENETICS

Genetics, diagnostics and therapeutic advances in NAFLD

(2015) Mary E. Rinella et al.   Nature Reviews Gastroenterology & Hepatology

Time-restricted feeding attenuates age-related cardiac decline in Drosophila

(2015) S. Gill et al.   SCIENCE

Gaining Insights into Diabetic Cardiomyopathy from Drosophila

(2015) Soda Balla Diop et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Neurophysiology ofDrosophilaModels of Parkinson’s Disease

(2015) Ryan J. H. West et al.   Parkinsons Disease

Synaptotagmin 2 Mutations Cause an Autosomal-Dominant Form of Lambert-Eaton Myasthenic Syndrome and Nonprogressive Motor Neuropathy

(2014) David N. Herrmann et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The global burden of liver disease: a challenge for methods and for public health

(2014) Peter Byass   BMC Medicine

A Drosophila Genetic Resource of Mutants to Study Mechanisms Underlying Human Genetic Diseases

(2014) Shinya Yamamoto et al.   CELL

Shared mechanisms between Drosophila peripheral nervous system development and human neurodegenerative diseases

(2014) Wu-Lin Charng et al.   CURRENT OPINION IN NEUROBIOLOGY

Modeling metabolic homeostasis and nutrient sensing in Drosophila: implications for aging and metabolic diseases

(2014) E. Owusu-Ansah et al.   Disease Models & Mechanisms

The Notch pathway: a novel target for myocardial remodelling therapy?

(2014) R. Ferrari et al.   EUROPEAN HEART JOURNAL

Large-scale identification of chemically induced mutations inDrosophila melanogaster

(2014) Nele A. Haelterman et al.   GENOME RESEARCH

Inherited disorders of the neuromuscular junction: an update

(2014) Pedro M. Rodríguez Cruz et al.   JOURNAL OF NEUROLOGY

Targeted genome engineering techniques in Drosophila

(2014) Kelly J. Beumer et al.   METHODS

Chemical mutagens, transposons, and transgenes to interrogate gene function in Drosophila melanogaster

(2014) Koen J.T. Venken et al.   METHODS

RNAi screening in Drosophila cells and in vivo

(2014) Stephanie E. Mohr   METHODS

Methods to assess Drosophila heart development, function and aging

(2014) Karen Ocorr et al.   METHODS

Aging and CaMKII Alter Intracellular Ca2+ Transients and Heart Rhythm in Drosophila melanogaster

(2014) Manuela Santalla et al.   PLoS One

Control of metabolic adaptation to fasting by dILP6-induced insulin signaling inDrosophilaoenocytes

(2014) Debamita Chatterjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid in vivo forward genetic approach for identifying axon death genes inDrosophila

(2014) Lukas J. Neukomm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axon Injury and Regeneration in the Adult Drosophila

(2014) Lorena Soares et al.   Scientific Reports

Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone production

(2014) Hector Sandoval et al.   eLife

The tiptop/teashirt genes regulate cell differentiation and renal physiology in Drosophila

(2013) B. Denholm et al.   DEVELOPMENT

The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit

(2013) Ke Zhang et al.   JOURNAL OF CELL BIOLOGY

An In Vivo Functional Analysis System for Renal Gene Discovery in Drosophila Pericardial Nephrocytes

(2013) F. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The NADPH Metabolic Network Regulates Human αB-crystallin Cardiomyopathy and Reductive Stress in Drosophila melanogaster

(2013) Heng B. Xie et al.   PLoS Genetics

The ultrastructure of Drosophila heart cells

(2012) Christine Lehmacher et al.   ARTHROPOD STRUCTURE & DEVELOPMENT

A Novel Drosophila Model of Nerve Injury Reveals an Essential Role of Nmnat in Maintaining Axonal Integrity

(2012) Yanshan Fang et al.   CURRENT BIOLOGY

Coordinating Tissue Interactions: Notch Signaling in Cardiac Development and Disease

(2012) José Luis de la Pompa et al.   DEVELOPMENTAL CELL

Investigation of lipid homeostasis in livingDrosophilaby coherent anti-Stokes Raman scattering microscopy

(2012) Cheng-Hao Chien et al.   JOURNAL OF BIOMEDICAL OPTICS

Probing the polygenic basis of cardiomyopathies in Drosophila

(2012) Li Qian et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ion and solute transport by Prestin in Drosophila and Anopheles

(2012) Taku Hirata et al.   JOURNAL OF INSECT PHYSIOLOGY

Mutations in the Mitochondrial Methionyl-tRNA Synthetase Cause a Neurodegenerative Phenotype in Flies and a Recessive Ataxia (ARSAL) in Humans

(2012) Vafa Bayat et al.   PLOS BIOLOGY

Drosophila melanogaster Acetyl-CoA-Carboxylase Sustains a Fatty Acid–Dependent Remote Signal to Waterproof the Respiratory System

(2012) Jean-Philippe Parvy et al.   PLoS Genetics

The generation of chromosomal deletions to provide extensive coverage and subdivision of the Drosophila melanogaster genome

(2012) R Kimberley Cook et al.   GENOME BIOLOGY

A Method to Measure Myocardial Calcium Handling in Adult Drosophila

(2011) Na Lin et al.   CIRCULATION RESEARCH

Drosophila, Genetic Screens, and Cardiac Function

(2011) Matthew J. Wolf et al.   CIRCULATION RESEARCH

A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila

(2011) L. Palanker Musselman et al.   Disease Models & Mechanisms

Expression of Perilipin and Adipophilin in Nonalcoholic Fatty Liver Disease; Relevance to Oxidative Injury and Hepatocyte Ballooning

(2011) Hideki Fujii et al.   Journal of Atherosclerosis and Thrombosis

Genetic Manipulation of Genes and Cells in the Nervous System of the Fruit Fly

(2011) Koen J.T. Venken et al.   NEURON

A Patient with Cubilin Deficiency

(2011) Tina Storm et al.   NEW ENGLAND JOURNAL OF MEDICINE

Drosophila Genome-wide Obesity Screen Reveals Hedgehog as a Determinant of Brown versus White Adipose Cell Fate

(2010) J. Andrew Pospisilik et al.   CELL

Gene Deletion Screen for Cardiomyopathy in Adult Drosophila Identifies a New Notch Ligand

(2010) Il-Man Kim et al.   CIRCULATION RESEARCH

Drosophila melanogaster as a model for human intestinal infection and pathology

(2010) Y. Apidianakis et al.   Disease Models & Mechanisms

Physiological homology between Drosophila melanogaster and vertebrate cardiovascular systems

(2010) M. A. Choma et al.   Disease Models & Mechanisms

Drosophila as a Model for Epilepsy: bss Is a Gain-of-Function Mutation in the Para Sodium Channel Gene That Leads to Seizures

(2010) L. Parker et al.   GENETICS

Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease

(2010) Brent A. Neuschwander-Tetri et al.   HEPATOLOGY

dCIP4 (Drosophila Cdc42-Interacting Protein 4) Restrains Synaptic Growth by Inhibiting the Secretion of the Retrograde Glass Bottom Boat Signal

(2010) M. Nahm et al.   JOURNAL OF NEUROSCIENCE

A New Chamber for Studying the Behavior of Drosophila

(2010) Jasper C. Simon et al.   PLoS One

The Developmental, Molecular, and Transport Biology of Malpighian Tubules

(2009) Klaus W. Beyenbach et al.   Annual Review of Entomology

A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts

(2009) Martin Fink et al.   BIOTECHNIQUES

Drosophila HNF4 Regulates Lipid Mobilization and β-Oxidation

(2009) Laura Palanker et al.   Cell Metabolism

High-throughput ethomics in large groups of Drosophila

(2009) Kristin Branson et al.   NATURE METHODS

Protocol for quantifying sound-sensing ability of Drosophila melanogaster

(2009) Hidehiko K Inagaki et al.   Nature Protocols

Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease

(2009) F. Kerr et al.   NEUROBIOLOGY OF AGING

Semi-automated Optical Heartbeat Analysis of Small Hearts

(2009) Karen Ocorr et al.   Jove-Journal of Visualized Experiments

Drosophila melanogaster for Physiological Studies

(2009) Ann S. Cooper et al.   Jove-Journal of Visualized Experiments

Molecular architecture of the fruit fly's airway epithelial immune system

(2008) Christina Wagner et al.   BMC GENOMICS

Metabolomic profiling ofDrosophilausing liquid chromatography Fourier transform mass spectrometry

(2008) M.A. Kamleh et al.   FEBS LETTERS

Prevalence of early-onset atrial fibrillation in congenital long QT syndrome

(2008) Jonathan N. Johnson et al.   HEART RHYTHM

ADrosophilaModel for Amyotrophic Lateral Sclerosis Reveals Motor Neuron Damage by Human SOD1

(2008) Melanie R. Watson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm

(2008) Helen Weavers et al.   NATURE

A Drosophila orphan G protein-coupled receptor BOSS functions as a glucose-responding receptor: Loss of boss causes abnormal energy metabolism

(2008) A. Kohyama-Koganeya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA