Spen modulates lipid droplet content in adult Drosophila glial cells and protects against paraquat toxicity

Gene-Diet Interactions: Dietary Rescue of Metabolic Defects in spen-depleted Drosophilamelanogaster

(2020) Claire M. Gillette et al.   GENETICS

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

(2020) Julia Marschallinger et al.   NATURE NEUROSCIENCE

Gene expression meta-analysis of Parkinson’s disease and its relationship with Alzheimer’s disease

(2019) Jack Kelly et al.   Molecular Brain

Structural and Functional Studies of the RBPJ-SHARP Complex Reveal a Conserved Corepressor Binding Site

(2019) Zhenyu Yuan et al.   Cell Reports

Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity

(2019) Maria S. Ioannou et al.   CELL

The NCATS BioPlanet – An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics

(2019) Ruili Huang et al.   Frontiers in Pharmacology

The TargetMine Data Warehouse: Enhancement and Updates

(2019) Yi-An Chen et al.   Frontiers in Genetics

A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain

(2018) Kristofer Davie et al.   CELL

Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina

(2018) Daan M. Van Den Brink et al.   PLoS Genetics

Drosophila p53 integrates the antagonism between autophagy and apoptosis in response to stress

(2018) Marion Robin et al.   Autophagy

Drosophila glia: Few cell types and many conserved functions

(2018) Kerem Yildirim et al.   GLIA

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

(2018) Saranna Fanning et al.   MOLECULAR CELL

Spen limits intestinal stem cell self-renewal

(2018) Maheva Andriatsilavo et al.   PLoS Genetics

An autonomous metabolic role for Spen

(2017) Kelsey E. Hazegh et al.   PLoS Genetics

Superoxide Dismutase (SOD)-mimetic M40403 Is Protective in Cell and Fly Models of Paraquat Toxicity

(2016) Roberta Filograna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes

(2016) Franz Oswald et al.   NUCLEIC ACIDS RESEARCH

Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila

(2015) Andrew P. Bailey et al.   CELL

Systematic Discovery of Xist RNA Binding Proteins

(2015) Ci Chu et al.   CELL

Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

(2015) Lucy Liu et al.   CELL

Spen is required for pigment cell survival during pupal development in Drosophila

(2015) Matthieu Querenet et al.   DEVELOPMENTAL BIOLOGY

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3

(2015) Colleen A. McHugh et al.   NATURE

spenitois required for sex determination inDrosophila melanogaster

(2015) Dong Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing

(2015) Benoit Moindrot et al.   Cell Reports

Identification of Spen as a Crucial Factor for Xist Function through Forward Genetic Screening in Haploid Embryonic Stem Cells

(2015) Asun Monfort et al.   Cell Reports

A Drosophila In Vivo Screen Identifies Store-Operated Calcium Entry as a Key Regulator of Adiposity

(2014) Jens Baumbach et al.   Cell Metabolism

A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila

(2014) Marlène Cassar et al.   HUMAN MOLECULAR GENETICS

Inflammasome activation restrictsLegionella pneumophilareplication in primary microglial cells through flagellin detection

(2013) Yvan Jamilloux et al.   GLIA

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Notch Signaling Modulates Sleep Homeostasis and Learning after Sleep Deprivation in Drosophila

(2011) Laurent Seugnet et al.   CURRENT BIOLOGY

Rotenone, Paraquat, and Parkinson’s Disease

(2011) Caroline M. Tanner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

PERILIPIN-Dependent Control of Lipid Droplet Structure and Fat Storage in Drosophila

(2010) Mathias Beller et al.   Cell Metabolism

A Combined Ex Vivo and In Vivo RNAi Screen for Notch Regulators in Drosophila Reveals an Extensive Notch Interaction Network

(2010) Abil Saj et al.   DEVELOPMENTAL CELL

A Buoyancy-Based Screen of Drosophila Larvae for Fat-Storage Mutants Reveals a Role for Sir2 in Coupling Fat Storage to Nutrient Availability

(2010) Tânia Reis et al.   PLoS Genetics

Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila

(2009) Reinhard Bauer et al.   EMBO JOURNAL

Requirement of Split ends for Epigenetic Regulation of Notch Signal-Dependent Genes during Infection-Induced Hemocyte Differentiation

(2009) L. H. Jin et al.   MOLECULAR AND CELLULAR BIOLOGY

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

(2008) Yi Guo et al.   NATURE

Spenito and Split ends act redundantly to promote Wingless signaling

(2007) Jinhee L. Chang et al.   DEVELOPMENTAL BIOLOGY