Clonal hematopoiesis driven by DNMT3A and TET2 mutations: role in monocyte and macrophage biology and atherosclerotic cardiovascular disease

Clonal Hematopoiesis and Risk of Progression of Heart Failure With Reduced Left Ventricular Ejection Fraction

(2021) Domingo A. Pascual-Figal et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers

(2021) Vinay S. Mahajan et al.   Nature Communications

Association of Clonal Hematopoiesis With Incident Heart Failure

(2021) Bing Yu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

LncRNA Dnmt3aos regulates Dnmt3a expression leading to aberrant DNA methylation in macrophage polarization

(2020) Xueqin Li et al.   FASEB JOURNAL

Measuring single cell divisions in human tissues from multi-region sequencing data

(2020) Benjamin Werner et al.   Nature Communications

Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness

(2020) Elizabeth L. Ostrander et al.   Stem Cell Reports

Clonal Hematopoiesis–Driver DNMT3A Mutations Alter Immune Cells in Heart Failure

(2020) Wesley Tyler Abplanalp et al.   CIRCULATION RESEARCH

Clonal haematopoiesis in chronic ischaemic heart failure: prognostic role of clone size for DNMT3A- and TET2-driver gene mutations

(2020) Birgit Assmus et al.   EUROPEAN HEART JOURNAL

Clonal haematopoiesis induces a pro-inflammatory monocyte phenotype in HF

(2020) Gregory B. Lim   Nature Reviews Cardiology

Somatic mutation and clonal expansions in human tissues

(2019) Inigo Martincorena   Genome Medicine

Genetic variation of DNA methyltransferase-3A contributes to protection against persistent MRSA bacteremia in patients

(2019) Felix Mba Medie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atherosclerosis

(2019) Peter Libby et al.   Nature Reviews Disease Primers

The Mutational Landscape of Pancreatic and Liver Cancers, as Represented by Circulating Tumor DNA

(2019) Alistair Rice et al.   Frontiers in Oncology

Mutations in BRCA1, BRCA2, and PALB2, and a panel of 50 cancer-associated genes in pancreatic ductal adenocarcinoma

(2018) Shoko Takeuchi et al.   Scientific Reports

Variation of mutational burden in healthy human tissues suggests non-random strand segregation and allows measuring somatic mutation rates

(2018) Benjamin Werner et al.   PLoS Computational Biology

Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine (5hmC)

(2018) Yajing Chu et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Somatic mutant clones colonize the human esophagus with age

(2018) Iñigo Martincorena et al.   SCIENCE

Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure

(2018) Lena Dorsheimer et al.   JAMA Cardiology

Tet2 restrains inflammatory gene expression in macrophages

(2017) Alyssa H. Cull et al.   EXPERIMENTAL HEMATOLOGY

Monocyte-Macrophages and T Cells in Atherosclerosis

(2017) Ira Tabas et al.   IMMUNITY

Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies

(2017) Christopher B. Cole et al.   JOURNAL OF CLINICAL INVESTIGATION

IRF3 and type I interferons fuel a fatal response to myocardial infarction

(2017) Kevin R King et al.   NATURE MEDICINE

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

(2017) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

(2017) José J. Fuster et al.   SCIENCE

Dnmt3a is an epigenetic mediator of adipose insulin resistance

(2017) Dongjoo You et al.   eLife

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Haidong Wang et al.   LANCET

DNMT3A R882H mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice

(2016) L Scourzic et al.   LEUKEMIA

Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity

(2016) Xia Li et al.   NATURE IMMUNOLOGY

Mosaicism in health and disease — clones picking up speed

(2016) Lars A. Forsberg et al.   NATURE REVIEWS GENETICS

Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis

(2016) Yuri V. Bobryshev et al.   Biomed Research International

High burden and pervasive positive selection of somatic mutations in normal human skin

(2015) I. Martincorena et al.   SCIENCE

Leukemia-Associated Somatic Mutations Drive Distinct Patterns of Age-Related Clonal Hemopoiesis

(2015) Thomas McKerrell et al.   Cell Reports

Somatic mutations, genome mosaicism, cancer and aging

(2014) Jan Vijg   CURRENT OPINION IN GENETICS & DEVELOPMENT

Age-related mutations associated with clonal hematopoietic expansion and malignancies

(2014) Mingchao Xie et al.   NATURE MEDICINE

Macrophage subsets in atherosclerosis

(2014) Giulia Chinetti-Gbaguidi et al.   Nature Reviews Cardiology

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Foam cells in atherosclerosis

(2013) Xiao-Hua Yu et al.   CLINICA CHIMICA ACTA

Opposing Roles of STAT4 and Dnmt3a in Th1 Gene Regulation

(2013) D. Pham et al.   JOURNAL OF IMMUNOLOGY

Monocytes in Coronary Artery Disease and Atherosclerosis

(2013) Angie Ghattas et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications

(2013) Amélie Bonnefond et al.   NATURE GENETICS

Somatic Mutations in Exocrine Pancreatic Tumors: Association with Patient Survival

(2013) P. Sivaramakrishna Rachakonda et al.   PLoS One

5-Hydroxymethylcytosine is an essential intermediate of active DNA demethylation processes in primary human monocytes

(2013) Maja Klug et al.   GENOME BIOLOGY

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype

(2012) Larissa Cardilo-Reis et al.   EMBO Molecular Medicine

Tet2 Facilitates the Derepression of Myeloid Target Genes during CEBPα-Induced Transdifferentiation of Pre-B Cells

(2012) Eric M. Kallin et al.   MOLECULAR CELL

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

(2011) Z. Li et al.   BLOOD

Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

(2011) Kelly Moran-Crusio et al.   CANCER CELL

Dnmt3a is essential for hematopoietic stem cell differentiation

(2011) Grant A Challen et al.   NATURE GENETICS

Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

(2011) M. Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA methyltransferase 3a limits the expression of interleukin-13 in T helper 2 cells and allergic airway inflammation

(2011) Q. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myeloid Type I Interferon Signaling Promotes Atherosclerosis by Stimulating Macrophage Recruitment to Lesions

(2010) Pieter Goossens et al.   Cell Metabolism

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Is Age Really a Non-Modifiable Cardiovascular Risk Factor?

(2009) William B. Kannel et al.   AMERICAN JOURNAL OF CARDIOLOGY

General Cardiovascular Risk Profile for Use in Primary Care

(2008) Ralph B. D’Agostino et al.   CIRCULATION

Age as a modifiable risk factor for cardiovascular disease

(2008) Allan D Sniderman et al.   LANCET