Aligned forces: Origins and mechanisms of cancer dissemination guided by extracellular matrix architecture

A Mechanical Instability in Planar Epithelial Monolayers Leads to Cell Extrusion

(2020) Satoru Okuda et al.   BIOPHYSICAL JOURNAL

Cell–cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion

(2020) Olga Ilina et al.   NATURE CELL BIOLOGY

Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression

(2020) Ori Maller et al.   NATURE MATERIALS

Randomly distributed K14+ breast tumor cells polarize to the leading edge to direct collective migration in response to chemical and mechanical environmental cues

(2019) Gregory D Longmore et al.   CANCER RESEARCH

Entropic Forces Drive Cellular Contact Guidance

(2019) Antonetta B.C. Buskermolen et al.   BIOPHYSICAL JOURNAL

Collagen organization of renal cell carcinoma differs between low and high grade tumors

(2019) Sara L. Best et al.   BMC CANCER

Second-harmonic generation microscopy analysis reveals proteoglycan decorin is necessary for proper collagen organization in prostate

(2019) Kirby R. Campbell et al.   JOURNAL OF BIOMEDICAL OPTICS

Tumor-secreted PAI-1 promotes breast cancer metastasis via the induction of adipocyte-derived collagen remodeling

(2019) Xiaohui Wei et al.   Cell Communication and Signaling

The tumor cell‐secreted matricellular protein WISP 1 drives pro‐metastatic collagen linearization

(2019) Hong Jia et al.   EMBO JOURNAL

Glioma Cell Migration Dynamics in Brain Tissue Assessed by Multimodal Optical Imaging

(2019) Chao J. Liu et al.   BIOPHYSICAL JOURNAL

Extracellular matrix anisotropy is determined by TFAP2C-dependent regulation of cell collisions

(2019) Danielle Park et al.   NATURE MATERIALS

The Presence of Cyclooxygenase 2, Tumor-Associated Macrophages, and Collagen Alignment as Prognostic Markers for Invasive Breast Carcinoma Patients

(2018) Karla Esbona et al.   AMERICAN JOURNAL OF PATHOLOGY

Dynamics of 3D carcinoma cell invasion into aligned collagen

(2018) Arja Ray et al.   Integrative Biology

Dia1-dependent adhesions are required by epithelial tissues to initiate invasion

(2018) Tim B. Fessenden et al.   JOURNAL OF CELL BIOLOGY

Antifibrotic Therapy Disrupts Stromal Barriers and Modulates the Immune Landscape in Pancreatic Ductal Adenocarcinoma

(2018) Kianna Y. Elahi-Gedwillo et al.   CANCER RESEARCH

Bimodal sensing of guidance cues in mechanically distinct microenvironments

(2018) Erdem D. Tabdanov et al.   Nature Communications

Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

(2018) Amanpreet Kaur et al.   Cancer Discovery

Microtubule-Actomyosin Mechanical Cooperation during Contact Guidance Sensing

(2018) Erdem D. Tabdanov et al.   Cell Reports

Stromal PTEN Regulates Extracellular Matrix Organization in the Mammary Gland

(2018) Caitlin E. Jones et al.   NEOPLASIA

Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix

(2017) Armen H. Mekhdjian et al.   MOLECULAR BIOLOGY OF THE CELL

Contact guidance requires spatial control of leading-edge protrusion

(2017) G. R. Ramirez-San Juan et al.   MOLECULAR BIOLOGY OF THE CELL

α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site

(2017) Y. A. Miroshnikova et al.   MOLECULAR BIOLOGY OF THE CELL

A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion

(2017) Anna Labernadie et al.   NATURE CELL BIOLOGY

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

(2017) Claire Vennin et al.   Science Translational Medicine

Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration

(2017) Arja Ray et al.   Nature Communications

Contact guidance persists under myosin inhibition due to the local alignment of adhesions and individual protrusions

(2017) Kristopher E. Kubow et al.   Scientific Reports

Matrix-regulated integrin αvβ5 maintains α5β1-dependent desmoplastic traits prognostic of neoplastic recurrence

(2017) Janusz Franco-Barraza et al.   eLife

Three-dimensional collagen matrix induces a mechanosensitive invasive epithelial phenotype

(2017) Shawn P. Carey et al.   Scientific Reports

Tumor Cell Invasion Can Be Blocked by Modulators of Collagen Fibril Alignment That Control Assembly of the Extracellular Matrix

(2016) Moran Grossman et al.   CANCER RESEARCH

SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland

(2016) Emilia Peuhu et al.   EMBO JOURNAL

Local extracellular matrix alignment directs cellular protrusion dynamics and migration through Rac1 and FAK

(2016) Shawn P. Carey et al.   Integrative Biology

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

(2016) Hong Jiang et al.   NATURE MEDICINE

ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis

(2016) D H Peng et al.   ONCOGENE

Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression

(2016) M. J. Oudin et al.   Cancer Discovery

The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis

(2016) Callie A.S. Corsa et al.   Cell Reports

MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma

(2015) O. Tatti et al.   CANCER RESEARCH

Periductal stromal collagen topology of pancreatic ductal adenocarcinoma differs from that of normal and chronic pancreatitis

(2015) Cole R Drifka et al.   MODERN PATHOLOGY

Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions

(2015) Andrew D. Doyle et al.   Nature Communications

Real-Time Imaging of Resident T Cells in Human Lung and Ovarian Carcinomas Reveals How Different Tumor Microenvironments Control T Lymphocyte Migration

(2015) Houcine Bougherara et al.   Frontiers in Immunology

3D Collagen Alignment Limits Protrusions to Enhance Breast Cancer Cell Persistence

(2014) Kristin M. Riching et al.   BIOPHYSICAL JOURNAL

Prevailing Role of Contact Guidance in Intrastromal T-cell Trapping in Human Pancreatic Cancer

(2014) N. Hartmann et al.   CLINICAL CANCER RESEARCH

Contact guidance of smooth muscle cells is associated with tension-mediated adhesion maturation

(2014) Akira C. Saito et al.   EXPERIMENTAL CELL RESEARCH

Nonautonomous contact guidance signaling during collective cell migration

(2014) Camila Londono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program

(2013) Kevin J. Cheung et al.   CELL

Matrix Microarchitecture and Myosin II Determine Adhesion in 3D Matrices

(2013) Kristopher E. Kubow et al.   CURRENT BIOLOGY

Patterned Collagen Fibers Orient Branching Mammary Epithelium through Distinct Signaling Modules

(2013) Douglas G. Brownfield et al.   CURRENT BIOLOGY

Preclinical intravital microscopy of the tumour-stroma interface: invasion, metastasis, and therapy response

(2013) Stephanie Alexander et al.   CURRENT OPINION IN CELL BIOLOGY

Rapid disorganization of mechanically interacting systems of mammary acini

(2013) Q. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

(2013) Vikash P. Chauhan et al.   Nature Communications

EMT and Dissemination Precede Pancreatic Tumor Formation

(2012) Andrew D. Rhim et al.   CELL

Host epithelial geometry regulates breast cancer cell invasiveness

(2012) E. Boghaert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium

(2012) K.-V. Nguyen-Ngoc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis

(2011) Jacky G. Goetz et al.   CELL

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

(2011) B. Diop-Frimpong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contact Guidance Mediated Three-Dimensional Cell Migration is Regulated by Rho/ROCK-Dependent Matrix Reorganization

(2008) Paolo P. Provenzano et al.   BIOPHYSICAL JOURNAL

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

Biomechanical regulation of cell orientation and fate

(2008) J I Lopez et al.   ONCOGENE