Microenvironmental effects can masquerade as substrate channelling in cascade biocatalysis

Cluster Channeling in Cascade Reactions

(2021) Irina V. Gopich   JOURNAL OF PHYSICAL CHEMISTRY B

Polymer Coatings on Virus-like Particle Nanoreactors at Low Ionic Strength—Charge Reversal and Substrate Access

(2021) Pawel Kraj et al.   BIOMACROMOLECULES

Organizing Multi-Enzyme Systems into Programmable Materials for Biocatalysis

(2021) Min-Ju Seo et al.   Catalysts

Molecular binding scaffolds increase local substrate concentration enhancing the enzymatic hydrolysis of VX nerve agent

(2020) Xuye Lang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Protein Encapsulation Using Complex Coacervates: What Nature Has to Teach Us

(2020) Whitney C. Blocher McTigue et al.   Small

Local Environment Affects the Activity of Enzymes on a 3D Molecular Scaffold

(2020) Yan Xiong et al.   ACS Nano

Intrinsically disordered linkers control tethered kinases via effective concentration

(2020) Mateusz Dyla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Can enzyme proximity accelerate cascade reactions?

(2019) Andrij Kuzmak et al.   Scientific Reports

Design Principles for a Compartmentalized Enzyme Cascade Reaction

(2019) Stanislav Tsitkov et al.   ACS Catalysis

Engineering the Microenvironment of a Thermostable Alcohol Dehydrogenase via Fusion with Supercharged Proteins Improves Catalysis

(2019) Walaa Abdallah et al.   CHEMBIOCHEM

Light-based control of metabolic flux through assembly of synthetic organelles

(2019) Evan M. Zhao et al.   Nature Chemical Biology

Tailoring enzyme microenvironment: State-of-the-art strategy to fulfill the quest for efficient bio-catalysis

(2019) Muhammad Bilal et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The Microenvironment in Immobilized Enzymes: Methods of Characterization and Its Role in Determining Enzyme Performance

(2019) Juan M. Bolivar et al.   MOLECULES

Enhanced Catalysis from Multienzyme Cascades Assembled on a DNA Origami Triangle

(2019) William P. Klein et al.   ACS Nano

Artificial Multienzyme Scaffolds: Pursuing in Vitro Substrate Channeling with an Overview of Current Progress

(2019) Gregory A. Ellis et al.   ACS Catalysis

Integrating enzyme immobilization and protein engineering: An alternative path for the development of novel and improved industrial biocatalysts

(2018) Claudia Bernal et al.   BIOTECHNOLOGY ADVANCES

Engineering enzyme microenvironments for enhanced biocatalysis

(2018) Louis Lancaster et al.   CHEMICAL SOCIETY REVIEWS

Substrate Sorting by a Supercharged Nanoreactor

(2018) Yusuke Azuma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Creation of a formate: malate oxidoreductase by fusion of dehydrogenase enzymes with PEGylated cofactor swing arms

(2018) Harun F Ozbakir et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Cascade Kinetics of an Artificial Metabolon by Molecular Dynamics and Kinetic Monte Carlo

(2018) Yuanchao Liu et al.   ACS Catalysis

Polyelectrolytes Tailored Enzyme Cascades with Enhanced Stability and Activity for One‐pot Synthesis

(2018) Zheyu Wang et al.   ChemCatChem

Enhanced Efficiency of an Enzyme Cascade on DNA-Activated Silica Surfaces

(2018) Kilian Vogele et al.   LANGMUIR

Advances and opportunities for the design of self-sufficient and spatially organized cell-free biocatalytic systems

(2018) Claudia Schmid-Dannert et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Does metabolite channeling accelerate enzyme-catalyzed cascade reactions?

(2017) Liubov Poshyvailo et al.   PLoS One

Increasing Enzyme Cascade Throughput by pH-Engineering the Microenvironment of Individual Enzymes

(2017) Yifei Zhang et al.   ACS Catalysis

Advanced characterization of immobilized enzymes as heterogeneous biocatalysts

(2016) Juan M. Bolivar et al.   CATALYSIS TODAY

Mechanisms of Enhanced Catalysis in Enzyme-DNA Nanostructures Revealed through Molecular Simulations and Experimental Analysis

(2016) Yingning Gao et al.   CHEMBIOCHEM

Substrate channelling as an approach to cascade reactions

(2016) Ian Wheeldon et al.   Nature Chemistry

Enzymatic reactions in confined environments

(2016) Andreas Küchler et al.   Nature Nanotechnology

Proximity does not contribute to activity enhancement in the glucose oxidase–horseradish peroxidase cascade

(2016) Yifei Zhang et al.   Nature Communications

Enhanced Activity of Immobilized or Chemically Modified Enzymes

(2015) Yifei Zhang et al.   ACS Catalysis

Tuning Enzyme Kinetics through Designed Intermolecular Interactions Far from the Active Site

(2015) Yingning Gao et al.   ACS Catalysis

A model study of sequential enzyme reactions and electrostatic channeling

(2014) Changsun Eun et al.   JOURNAL OF CHEMICAL PHYSICS

Enzyme clustering accelerates processing of intermediates through metabolic channeling

(2014) Michele Castellana et al.   NATURE BIOTECHNOLOGY

Multi-enzyme complexes on DNA scaffolds capable of substrate channelling with an artificial swinging arm

(2014) Jinglin Fu et al.   Nature Nanotechnology

Origins of Activity Enhancement in Enzyme Cascades on Scaffolds

(2013) Ofer Idan et al.   ACS Nano

Evaluation of immobilized enzymes for industrial applications

(2013) Andreas Liese et al.   CHEMICAL SOCIETY REVIEWS

Modifying enzyme activity and selectivity by immobilization

(2012) Rafael C. Rodrigues et al.   CHEMICAL SOCIETY REVIEWS

Interenzyme Substrate Diffusion for an Enzyme Cascade Organized on Spatially Addressable DNA Nanostructures

(2012) Jinglin Fu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Channeling by Proximity: The Catalytic Advantages of Active Site Colocalization Using Brownian Dynamics

(2010) Patricia Bauler et al.   Journal of Physical Chemistry Letters