Does metabolite channeling accelerate enzyme-catalyzed cascade reactions?

Discrete-continuous reaction-diffusion model with mobile point-like sources and sinks

(2016) Svyatoslav Kondrat et al.   EUROPEAN PHYSICAL JOURNAL E

Substrate channelling as an approach to cascade reactions

(2016) Ian Wheeldon et al.   Nature Chemistry

Nanocaged enzymes with enhanced catalytic activity and increased stability against protease digestion

(2016) Zhao Zhao et al.   Nature Communications

Enzyme fusion for whole-cell biotransformation of long-chain sec-alcohols into esters

(2015) Eun-Yeong Jeon et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Variance-corrected Michaelis-Menten equation predicts transient rates of single-enzyme reactions and response times in bacterial gene-regulation

(2015) Otto Pulkkinen et al.   Scientific Reports

Binding and Channeling of Alternative Substrates in the Enzyme DmpFG: a Molecular Dynamics Study

(2014) Natalie E. Smith et al.   BIOPHYSICAL JOURNAL

Electrostatic Channeling in P. falciparum DHFR-TS: Brownian Dynamics and Smoluchowski Modeling

(2014) Vincent T. Metzger et al.   BIOPHYSICAL JOURNAL

First Evidence for Substrate Channeling between Proline Catabolic Enzymes

(2014) Nikhilesh Sanyal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A model study of sequential enzyme reactions and electrostatic channeling

(2014) Changsun Eun et al.   JOURNAL OF CHEMICAL PHYSICS

Ageing and confinement in non-ergodic heterogeneous diffusion processes

(2014) Andrey G Cherstvy et al.   Journal of Physics A-Mathematical and Theoretical

Enzyme clustering accelerates processing of intermediates through metabolic channeling

(2014) Michele Castellana et al.   NATURE BIOTECHNOLOGY

Anomalous diffusion models and their properties: non-stationarity, non-ergodicity, and ageing at the centenary of single particle tracking

(2014) Ralf Metzler et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Structures of the PutA peripheral membrane flavoenzyme reveal a dynamic substrate-channeling tunnel and the quinone-binding site

(2014) Harkewal Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzyme immobilisation in biocatalysis: why, what and how

(2013) Roger A. Sheldon et al.   CHEMICAL SOCIETY REVIEWS

Optimization of collective enzyme activity via spatial localization

(2013) Alexander Buchner et al.   JOURNAL OF CHEMICAL PHYSICS

Clustering and Optimal Arrangement of Enzymes in Reaction-Diffusion Systems

(2013) Alexander Buchner et al.   PHYSICAL REVIEW LETTERS

Annexation of a High-Activity Enzyme in a Synthetic Three-Enzyme Complex Greatly Decreases the Degree of Substrate Channeling

(2013) Chun You et al.   ACS Synthetic Biology

Facilitated Substrate Channeling in a Self-Assembled Trifunctional Enzyme Complex

(2012) Chun You et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biological Channeling of a Reactive Intermediate in the Bifunctional Enzyme DmpFG

(2012) Natalie E. Smith et al.   BIOPHYSICAL JOURNAL

Substrate channeling and enzyme complexes for biotechnological applications

(2011) Y.-H. Percival Zhang   BIOTECHNOLOGY ADVANCES

Browndye: A software package for Brownian dynamics

(2010) Gary A. Huber et al.   COMPUTER PHYSICS COMMUNICATIONS

Channeling by Proximity: The Catalytic Advantages of Active Site Colocalization Using Brownian Dynamics

(2010) Patricia Bauler et al.   Journal of Physical Chemistry Letters

Spatio-temporal correlations can drastically change the response of a MAPK pathway

(2010) K. Takahashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the bifunctional proline utilization A flavoenzyme from Bradyrhizobium japonicum

(2010) D. Srivastava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stochastic reaction-diffusion kinetics in the microscopic limit

(2010) D. Fange et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diffusion, Crowding & Protein Stability in a Dynamic Molecular Model of the Bacterial Cytoplasm

(2010) Sean R. McGuffee et al.   PLoS Computational Biology

Effect of Macromolecular Crowding on Reaction Rates: A Computational and Theoretical Study

(2009) Jun Soo Kim et al.   BIOPHYSICAL JOURNAL

Synthetic metabolic pipelines

(2009) Matthew P DeLisa et al.   NATURE BIOTECHNOLOGY