Loss of gut barrier integrity triggers activation of islet-reactive T cells and autoimmune diabetes

The human gut microbiome in early-onset type 1 diabetes from the TEDDY study

(2018) Tommi Vatanen et al.   NATURE

Akkermansia muciniphilainduces gut microbiota remodelling and controls islet autoimmunity in NOD mice

(2017) Arno Hänninen et al.   GUT

The microbiota protects against respiratory infection via GM-CSF signaling

(2017) Rebecca L. Brown et al.   Nature Communications

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans

(2016) Tommi Vatanen et al.   CELL

Defensins, lectins, mucins, and secretory immunoglobulin A: microbe-binding biomolecules that contribute to mucosal immunity in the human gut

(2016) Phoom Chairatana et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism

(2016) Thomas C. Fung et al.   IMMUNITY

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

(2016) David K. Cole et al.   JOURNAL OF CLINICAL INVESTIGATION

Germ-free and Antibiotic-treated Mice are Highly Susceptible to Epithelial Injury in DSS Colitis

(2016) Cristina Hernández-Chirlaque et al.   Journal of Crohns & Colitis

Microbial antigen mimics activate diabetogenic CD8 T cells in NOD mice

(2016) Ningwen Tai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset

(2016) Frederico R.C. Costa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The role of the intestinal microbiota in type 1 diabetes mellitus

(2016) Mikael Knip et al.   Nature Reviews Endocrinology

Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site

(2015) Reiko Horai et al.   IMMUNITY

Pancreatic β-Cells Limit Autoimmune Diabetes via an Immunoregulatory Antimicrobial Peptide Expressed under the Influence of the Gut Microbiota

(2015) Jia Sun et al.   IMMUNITY

The role for gut permeability in the pathogenesis of type 1 diabetes - a solid or leaky concept?

(2015) Xia Li et al.   PEDIATRIC DIABETES

Markers of innate immune activity in patients with type 1 and type 2 diabetes mellitus and the effect of the anti-oxidant coenzyme Q10 on inflammatory activity

(2014) H. Brauner et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

(2014) Thaher Pelaseyed et al.   IMMUNOLOGICAL REVIEWS

REG3γ-deficient mice have altered mucus distribution and increased mucosal inflammatory responses to the microbiota and enteric pathogens in the ileum

(2013) L MP Loonen et al.   Mucosal Immunology

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

The gastrointestinal mucus system in health and disease

(2013) Malin E. V. Johansson et al.   Nature Reviews Gastroenterology & Hepatology

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

(2013) M. Shan et al.   SCIENCE

Is the origin of type 1 diabetes in the gut?

(2012) Outi Vaarala   IMMUNOLOGY AND CELL BIOLOGY

MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli

(2012) Y H Sheng et al.   Mucosal Immunology

Colonic microbiota alters host susceptibility to infectious colitis by modulating inflammation, redox status, and ion transporter gene expression

(2011) S. Ghosh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Defective Differentiation of Regulatory FoxP3+ T Cells by Small-Intestinal Dendritic Cells in Patients With Type 1 Diabetes

(2011) E. Badami et al.   DIABETES

Cathelicidin Signaling via the Toll-like Receptor Protects Against Colitis in Mice

(2011) Hon Wai Koon et al.   GASTROENTEROLOGY

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

The Incidence of Type-1 Diabetes in NOD Mice Is Modulated by Restricted Flora Not Germ-Free Conditions

(2011) Cecile King et al.   PLoS One

Gut Microbiome Metagenomics Analysis Suggests a Functional Model for the Development of Autoimmunity for Type 1 Diabetes

(2011) Christopher T. Brown et al.   PLoS One

Etiology of Type 1 Diabetes

(2010) John A. Todd   IMMUNITY

Toward defining the autoimmune microbiome for type 1 diabetes

(2010) Adriana Giongo et al.   ISME Journal

Chromogranin A is an autoantigen in type 1 diabetes

(2010) Brian D Stadinski et al.   NATURE IMMUNOLOGY

Bacteria Penetrate the Inner Mucus Layer before Inflammation in the Dextran Sulfate Colitis Model

(2010) Malin E. V. Johansson et al.   PLoS One

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Gut barrier disruption by an enteric bacterial pathogen accelerates insulitis in NOD mice

(2009) A. S. Lee et al.   DIABETOLOGIA

Leaking gut in type 1 diabetes

(2008) Outi Vaarala   CURRENT OPINION IN GASTROENTEROLOGY

The "Perfect Storm" for Type 1 Diabetes: The Complex Interplay Between Intestinal Microbiota, Gut Permeability, and Mucosal Immunity

(2008) O. Vaarala et al.   DIABETES

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

(2008) Li Wen et al.   NATURE