Lipotoxicity: a driver of heart failure with preserved ejection fraction?

Burden of heart failure and underlying causes in 195 countries and territories from 1990 to 2017

(2021) Nicola Luigi Bragazzi et al.   European Journal of Preventive Cardiology

Cardiac Energy Metabolism in Heart Failure

(2021) Gary D. Lopaschuk et al.   CIRCULATION RESEARCH

The Control of Diastolic Calcium in the Heart

(2020) David A. Eisner et al.   CIRCULATION RESEARCH

Clinical Phenogroups in Heart Failure With Preserved Ejection Fraction

(2020) Jordana B. Cohen et al.   JACC-Heart Failure

Economic impact of heart failure with preserved ejection fraction: insights from the ALDO‐DHF trial

(2020) Djawid Hashemi et al.   ESC Heart Failure

Distinctive patterns of inflammation across the heart failure syndrome

(2020) Gabriele G. Schiattarella et al.   HEART FAILURE REVIEWS

Prohibitin 2 deficiency impairs cardiac fatty acid oxidation and causes heart failure

(2020) Dechao Wu et al.   Cell Death & Disease

Increasing Fatty Acid Oxidation Prevents High Fat Diet Induced Cardiomyopathy through Regulating Parkin Mediated Mitophagy

(2020) Dan Shao et al.   CIRCULATION

NAFLD is related to Post‐prandial Triglyceride‐enrichment of HDL Particles in Association with Endothelial and HDL Dysfunction

(2020) Bart J. Verwer et al.   LIVER INTERNATIONAL

Proteomic Evaluation of the Comorbidity-Inflammation Paradigm in Heart Failure with Preserved Ejection Fraction:Results from the PROMIS-HFpEF Study

(2020) Sandra Sanders-van Wijk et al.   CIRCULATION

Long-Chain Acylcarnitines and Cardiac Excitation-Contraction Coupling: Links to Arrhythmias

(2020) Hamish M. Aitken-Buck et al.   Frontiers in Physiology

Relationship Between Focal and Diffuse Fibrosis Assessed by CMR and Clinical Outcomes in Heart Failure With Preserved Ejection Fraction

(2019) Prathap Kanagala et al.   JACC-Cardiovascular Imaging

Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy

(2019) Mingming Tong et al.   CIRCULATION RESEARCH

Mitochondrial Dysfunction in Heart Failure With Preserved Ejection Fraction

(2019) Anupam A. Kumar et al.   CIRCULATION

Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy

(2019) Michinari Nakamura et al.   Cell Metabolism

How to diagnose heart failure with preserved ejection fraction: the HFA–PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)

(2019) Burkert Pieske et al.   EUROPEAN HEART JOURNAL

Myocardial adipose deposition and the development of heart failure with preserved ejection fraction

(2019) Cho‐Kai Wu et al.   EUROPEAN JOURNAL OF HEART FAILURE

Endothelium‐dependent and independent coronary microvascular dysfunction in patients with heart failure with preserved ejection fraction

(2019) Jeong Hoon Yang et al.   EUROPEAN JOURNAL OF HEART FAILURE

Coronary microvascular dysfunction in patients with heart failure with preserved ejection fraction

(2018) Kathryn Dryer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes

(2018) Brittany A. Law et al.   FASEB JOURNAL

Manifestations and mechanisms of myocardial lipotoxicity in obesity

(2018) A. C. Sletten et al.   JOURNAL OF INTERNAL MEDICINE

Decreased ATP production and myocardial contractile reserve in metabolic heart disease

(2018) Ivan Luptak et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals

(2018) Nathalie Conrad et al.   LANCET

Prevalence and correlates of coronary microvascular dysfunction in heart failure with preserved ejection fraction: PROMIS-HFpEF

(2018) Sanjiv J Shah et al.   EUROPEAN HEART JOURNAL

Decrease in membrane phospholipids unsaturation correlates with myocardial diastolic dysfunction

(2018) Tsunehisa Yamamoto et al.   PLoS One

Coronary microvascular dysfunction and future risk of heart failure with preserved ejection fraction

(2017) Viviany R Taqueti et al.   EUROPEAN HEART JOURNAL

Biological Phenotypes of Heart Failure With Preserved Ejection Fraction

(2017) Gavin A. Lewis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Heart Failure With Preserved, Borderline, and Reduced Ejection Fraction

(2017) Kevin S. Shah et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Epidemiology of heart failure with preserved ejection fraction

(2017) Shannon M. Dunlay et al.   Nature Reviews Cardiology

Inflammatory Biomarkers Predict Heart Failure Severity and Prognosis in Patients With Heart Failure With Preserved Ejection FractionCLINICAL PERSPECTIVE

(2017) Camilla Hage et al.   Circulation-Cardiovascular Genetics

Myocardial steatosis as a possible mechanistic link between diastolic dysfunction and coronary microvascular dysfunction in women

(2016) Janet Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Diastolic dysfunction in prediabetic male rats: Role of mitochondrial oxidative stress

(2016) Gábor Koncsos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Fuel availability and fate in cardiac metabolism: A tale of two substrates

(2016) Florencia Pascual et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipid Use and Misuse by the Heart

(2016) P. Christian Schulze et al.   CIRCULATION RESEARCH

Preservation of myocardial fatty acid oxidation prevents diastolic dysfunction in mice subjected to angiotensin II infusion

(2016) Yong Seon Choi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes

(2016) Leroy C. Joseph et al.   PLoS One

Myocardial Microvascular Inflammatory Endothelial Activation in Heart Failure With Preserved Ejection Fraction

(2016) Constantijn Franssen et al.   JACC-Heart Failure

Myocardial Stiffness in Patients With Heart Failure and a Preserved Ejection Fraction: Contributions of Collagen and Titin

(2015) M. R. Zile et al.   CIRCULATION

Evidence of microvascular dysfunction in heart failure with preserved ejection fraction

(2015) Joshua F Lee et al.   HEART

Myocardial hypertrophy and its role in heart failure with preserved ejection fraction

(2015) Frank R. Heinzel et al.   JOURNAL OF APPLIED PHYSIOLOGY

Mechanisms for redox-regulation of protein kinase C

(2015) Susan F. Steinberg   Frontiers in Pharmacology

Cardiac diastolic dysfunction in high-fat diet fed mice is associated with lipotoxicity without impairment of cardiac energetics in vivo

(2014) Desiree Abdurrachim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Gigantic Business

(2014) Wolfgang A. Linke et al.   CIRCULATION RESEARCH

Cardiac Structure and Function and Prognosis in Heart Failure With Preserved Ejection Fraction

(2014) Amil M. Shah et al.   Circulation-Heart Failure

Targeting the unfolded protein response in heart diseases

(2014) Man Liu et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Mitochondrial cholesterol: mechanisms of import and effects on mitochondrial function

(2014) Laura A. Martin et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity

(2014) Bharat Jaishy et al.   JOURNAL OF LIPID RESEARCH

The pathophysiology of heart failure with preserved ejection fraction

(2014) Barry A. Borlaug   Nature Reviews Cardiology

CMR-Verified Diffuse Myocardial Fibrosis Is Associated With Diastolic Dysfunction in HFpEF

(2014) Mao-Yuan M. Su et al.   JACC-Cardiovascular Imaging

Cardiac Steatosis and Left Ventricular Hypertrophy in Patients With Generalized Lipodystrophy as Determined by Magnetic Resonance Spectroscopy and Imaging

(2013) Michael D. Nelson et al.   AMERICAN JOURNAL OF CARDIOLOGY

Hyperglycemia-Induced Secretion of Endothelial Heparanase Stimulates a Vascular Endothelial Growth Factor Autocrine Network in Cardiomyocytes That Promotes Recruitment of Lipoprotein Lipase

(2013) Dahai Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cardiac oxidative stress in a mouse model of neutral lipid storage disease

(2013) Astrid Schrammel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy

(2013) N Fillmore et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cardiac Metabolism in Heart Failure

(2013) Torsten Doenst et al.   CIRCULATION RESEARCH

The obesity paradox in heart failure patients with preserved versus reduced ejection fraction: a meta-analysis of individual patient data

(2013) R Padwal et al.   INTERNATIONAL JOURNAL OF OBESITY

A Novel Paradigm for Heart Failure With Preserved Ejection Fraction

(2013) Walter J. Paulus et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Interleukin-16 Promotes Cardiac Fibrosis and Myocardial Stiffening in Heart Failure with Preserved Ejection Fraction

(2013) Shunsuke Tamaki et al.   PLoS One

Lipotoxicity contributes to endothelial dysfunction: A focus on the contribution from ceramide

(2013) J. David Symons et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Calcium mishandling in diastolic dysfunction: Mechanisms and potential therapies

(2012) Michelle L. Asp et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Carnitine Palmitoyltransferase-1b Deficiency Aggravates Pressure Overload–Induced Cardiac Hypertrophy Caused by Lipotoxicity

(2012) Lan He et al.   CIRCULATION

Ventricular Assist Device Implantation Corrects Myocardial Lipotoxicity, Reverses Insulin Resistance, and Normalizes Cardiac Metabolism in Patients With Advanced Heart Failure

(2012) Aalap Chokshi et al.   CIRCULATION

Low Myocardial Protein Kinase G Activity in Heart Failure With Preserved Ejection Fraction

(2012) Loek van Heerebeek et al.   CIRCULATION

Cyclic GMP-Dependent Signaling in Cardiac Myocytes

(2012) Eiki Takimoto   CIRCULATION JOURNAL

Cardiac-Specific Deletion of Acetyl CoA Carboxylase 2 Prevents Metabolic Remodeling During Pressure-Overload Hypertrophy

(2012) Stephen C. Kolwicz et al.   CIRCULATION RESEARCH

Ceramide Mediates Vascular Dysfunction in Diet-Induced Obesity by PP2A-Mediated Dephosphorylation of the eNOS-Akt Complex

(2012) Q.-J. Zhang et al.   DIABETES

Association between Serum Total Antioxidant Status and Coronary Microvascular Functions in Patients with SLE

(2012) Sema Yılmaz et al.   ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES

Obesity-Related Alterations in Cardiac Lipid Profile and Nondipping Blood Pressure Pattern during Transition to Diastolic Dysfunction in Male db/db Mice

(2012) Vincent G. DeMarco et al.   ENDOCRINOLOGY

Diacylglycerol acyl transferase 1 overexpression detoxifies cardiac lipids in PPARγ transgenic mice

(2012) Li Liu et al.   JOURNAL OF LIPID RESEARCH

Oxidative stress and cardiac hypertrophy: a review

(2012) Subir Kumar Maulik et al.   TOXICOLOGY MECHANISMS AND METHODS

Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction

(2011) Marco Guazzi et al.   CIRCULATION

Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heart

(2011) Ethan J Anderson et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Plasma levels of tumor necrosis factor-α and interleukin-6 are associated with diastolic heart failure through downregulation of sarcoplasmic reticulum Ca2+ ATPase

(2011) Cho-Kai Wu et al.   CRITICAL CARE MEDICINE

Chronic exposure to high fatty acids impedes receptor agonist-induced nitric oxide production and increments of cytosolic Ca2+ levels in endothelial cells

(2011) Yanxia Tang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Inflammation is Related to Coronary Flow Reserve Detected by Positron Emission Tomography in Asymptomatic Male Twins

(2011) Viola Vaccarino et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Pentraxin 3 Is a New Inflammatory Marker Correlated With Left Ventricular Diastolic Dysfunction and Heart Failure With Normal Ejection Fraction

(2011) Junichi Matsubara et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy

(2011) Dao-Fu Dai et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Myocardial ATGL Overexpression Decreases the Reliance on Fatty Acid Oxidation and Protects against Pressure Overload-Induced Cardiac Dysfunction

(2011) P. C. Kienesberger et al.   MOLECULAR AND CELLULAR BIOLOGY

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

(2011) Guenter Haemmerle et al.   NATURE MEDICINE

Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome — An allostatic perspective

(2010) Sam Virtue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Rescue of Cardiomyopathy in Peroxisome Proliferator-Activated Receptor-α Transgenic Mice by Deletion of Lipoprotein Lipase Identifies Sources of Cardiac Lipids and Peroxisome Proliferator-Activated Receptor-α Activators

(2010) Jennifer G. Duncan et al.   CIRCULATION

Uncoupled Cardiac Nitric Oxide Synthase Mediates Diastolic Dysfunction

(2010) Gad A. Silberman et al.   CIRCULATION

Cardiac Titin

(2010) Martin M. LeWinter et al.   CIRCULATION

Cardiac Inflammation Contributes to Changes in the Extracellular Matrix in Patients With Heart Failure and Normal Ejection Fraction

(2010) Dirk Westermann et al.   Circulation-Heart Failure

Modulation of cardiac ryanodine receptor activity by ROS and RNS

(2010) Paulina Donoso   Frontiers in Bioscience-Landmark

Free fatty acids induce endothelial dysfunction and activate protein kinase C and nuclear factor-κB pathway in rat aorta

(2010) Hua Li et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation

(2010) Ni-Huiping Son et al.   JOURNAL OF CLINICAL INVESTIGATION

Myocardial Fatty Acid Metabolism in Health and Disease

(2010) Gary D. Lopaschuk et al.   PHYSIOLOGICAL REVIEWS

Modulation of Titin-Based Stiffness by Disulfide Bonding in the Cardiac Titin N2-B Unique Sequence

(2009) Anika Grützner et al.   BIOPHYSICAL JOURNAL

Proteomic remodelling of mitochondrial oxidative pathways in pressure overload-induced heart failure

(2009) Heiko Bugger et al.   CARDIOVASCULAR RESEARCH

Harmonizing the Metabolic Syndrome

(2009) K.G.M.M. Alberti et al.   CIRCULATION

Hypophosphorylation of the Stiff N2B Titin Isoform Raises Cardiomyocyte Resting Tension in Failing Human Myocardium

(2009) Attila Borbély et al.   CIRCULATION RESEARCH

Insulin-Stimulated Cardiac Glucose Oxidation Is Increased in High-Fat Diet-Induced Obese Mice Lacking Malonyl CoA Decarboxylase

(2009) J. R. Ussher et al.   DIABETES

Myocardial lipid accumulation in patients with pressure-overloaded heart and metabolic syndrome

(2009) Raffaele Marfella et al.   JOURNAL OF LIPID RESEARCH

Altered Myocardial Substrate Metabolism and Decreased Diastolic Function in Nonischemic Human Diabetic Cardiomyopathy

(2009) Luuk J. Rijzewijk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Peroxynitrite increases protein phosphatase activity and promotes the interaction of phospholamban with protein phosphatase 2a in the myocardium

(2009) Mark J. Kohr et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Heart Failure With Preserved and Reduced Left Ventricular Ejection Fraction in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial

(2008) Barry R. Davis et al.   CIRCULATION

Ceramide is a cardiotoxin in lipotoxic cardiomyopathy

(2008) Tae-Sik Park et al.   JOURNAL OF LIPID RESEARCH

Lentiviral Vector–mediated SERCA2 Gene Transfer Protects Against Heart Failure and Left Ventricular Remodeling After Myocardial Infarction in Rats

(2008) Kazuo Niwano et al.   MOLECULAR THERAPY

Diastolic Stiffness of the Failing Diabetic Heart

(2007) Loek van Heerebeek et al.   CIRCULATION

Prognosis of heart failure with preserved ejection fraction: a 5 year prospective population-based study

(2007) C. Tribouilloy et al.   EUROPEAN HEART JOURNAL

Progressive Caloric Restriction Induces Dose-Dependent Changes in Myocardial Triglyceride Content and Diastolic Function in Healthy Men

(2007) Sebastiaan Hammer et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM