标题
Lipotoxicity: a driver of heart failure with preserved ejection fraction?
作者
关键词
-
出版物
CLINICAL SCIENCE
Volume 135, Issue 19, Pages 2265-2283
出版商
Portland Press Ltd.
发表日期
2021-10-18
DOI
10.1042/cs20210127
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Burden of heart failure and underlying causes in 195 countries and territories from 1990 to 2017
- (2021) Nicola Luigi Bragazzi et al. European Journal of Preventive Cardiology
- Cardiac Energy Metabolism in Heart Failure
- (2021) Gary D. Lopaschuk et al. CIRCULATION RESEARCH
- The Control of Diastolic Calcium in the Heart
- (2020) David A. Eisner et al. CIRCULATION RESEARCH
- Clinical Phenogroups in Heart Failure With Preserved Ejection Fraction
- (2020) Jordana B. Cohen et al. JACC-Heart Failure
- Economic impact of heart failure with preserved ejection fraction: insights from the ALDO‐DHF trial
- (2020) Djawid Hashemi et al. ESC Heart Failure
- Distinctive patterns of inflammation across the heart failure syndrome
- (2020) Gabriele G. Schiattarella et al. HEART FAILURE REVIEWS
- Prohibitin 2 deficiency impairs cardiac fatty acid oxidation and causes heart failure
- (2020) Dechao Wu et al. Cell Death & Disease
- Increasing Fatty Acid Oxidation Prevents High Fat Diet Induced Cardiomyopathy through Regulating Parkin Mediated Mitophagy
- (2020) Dan Shao et al. CIRCULATION
- NAFLD is related to Post‐prandial Triglyceride‐enrichment of HDL Particles in Association with Endothelial and HDL Dysfunction
- (2020) Bart J. Verwer et al. LIVER INTERNATIONAL
- Proteomic Evaluation of the Comorbidity-Inflammation Paradigm in Heart Failure with Preserved Ejection Fraction:Results from the PROMIS-HFpEF Study
- (2020) Sandra Sanders-van Wijk et al. CIRCULATION
- Long-Chain Acylcarnitines and Cardiac Excitation-Contraction Coupling: Links to Arrhythmias
- (2020) Hamish M. Aitken-Buck et al. Frontiers in Physiology
- Relationship Between Focal and Diffuse Fibrosis Assessed by CMR and Clinical Outcomes in Heart Failure With Preserved Ejection Fraction
- (2019) Prathap Kanagala et al. JACC-Cardiovascular Imaging
- Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy
- (2019) Mingming Tong et al. CIRCULATION RESEARCH
- Mitochondrial Dysfunction in Heart Failure With Preserved Ejection Fraction
- (2019) Anupam A. Kumar et al. CIRCULATION
- Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy
- (2019) Michinari Nakamura et al. Cell Metabolism
- How to diagnose heart failure with preserved ejection fraction: the HFA–PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)
- (2019) Burkert Pieske et al. EUROPEAN HEART JOURNAL
- Myocardial adipose deposition and the development of heart failure with preserved ejection fraction
- (2019) Cho‐Kai Wu et al. EUROPEAN JOURNAL OF HEART FAILURE
- Endothelium‐dependent and independent coronary microvascular dysfunction in patients with heart failure with preserved ejection fraction
- (2019) Jeong Hoon Yang et al. EUROPEAN JOURNAL OF HEART FAILURE
- Coronary microvascular dysfunction in patients with heart failure with preserved ejection fraction
- (2018) Kathryn Dryer et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes
- (2018) Brittany A. Law et al. FASEB JOURNAL
- Manifestations and mechanisms of myocardial lipotoxicity in obesity
- (2018) A. C. Sletten et al. JOURNAL OF INTERNAL MEDICINE
- Decreased ATP production and myocardial contractile reserve in metabolic heart disease
- (2018) Ivan Luptak et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals
- (2018) Nathalie Conrad et al. LANCET
- Prevalence and correlates of coronary microvascular dysfunction in heart failure with preserved ejection fraction: PROMIS-HFpEF
- (2018) Sanjiv J Shah et al. EUROPEAN HEART JOURNAL
- Decrease in membrane phospholipids unsaturation correlates with myocardial diastolic dysfunction
- (2018) Tsunehisa Yamamoto et al. PLoS One
- Coronary microvascular dysfunction and future risk of heart failure with preserved ejection fraction
- (2017) Viviany R Taqueti et al. EUROPEAN HEART JOURNAL
- Biological Phenotypes of Heart Failure With Preserved Ejection Fraction
- (2017) Gavin A. Lewis et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Heart Failure With Preserved, Borderline, and Reduced Ejection Fraction
- (2017) Kevin S. Shah et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Epidemiology of heart failure with preserved ejection fraction
- (2017) Shannon M. Dunlay et al. Nature Reviews Cardiology
- Inflammatory Biomarkers Predict Heart Failure Severity and Prognosis in Patients With Heart Failure With Preserved Ejection FractionCLINICAL PERSPECTIVE
- (2017) Camilla Hage et al. Circulation-Cardiovascular Genetics
- Myocardial steatosis as a possible mechanistic link between diastolic dysfunction and coronary microvascular dysfunction in women
- (2016) Janet Wei et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Diastolic dysfunction in prediabetic male rats: Role of mitochondrial oxidative stress
- (2016) Gábor Koncsos et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Fuel availability and fate in cardiac metabolism: A tale of two substrates
- (2016) Florencia Pascual et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Lipid Use and Misuse by the Heart
- (2016) P. Christian Schulze et al. CIRCULATION RESEARCH
- Preservation of myocardial fatty acid oxidation prevents diastolic dysfunction in mice subjected to angiotensin II infusion
- (2016) Yong Seon Choi et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes
- (2016) Leroy C. Joseph et al. PLoS One
- Myocardial Microvascular Inflammatory Endothelial Activation in Heart Failure With Preserved Ejection Fraction
- (2016) Constantijn Franssen et al. JACC-Heart Failure
- Myocardial Stiffness in Patients With Heart Failure and a Preserved Ejection Fraction: Contributions of Collagen and Titin
- (2015) M. R. Zile et al. CIRCULATION
- Evidence of microvascular dysfunction in heart failure with preserved ejection fraction
- (2015) Joshua F Lee et al. HEART
- Myocardial hypertrophy and its role in heart failure with preserved ejection fraction
- (2015) Frank R. Heinzel et al. JOURNAL OF APPLIED PHYSIOLOGY
- Mechanisms for redox-regulation of protein kinase C
- (2015) Susan F. Steinberg Frontiers in Pharmacology
- Cardiac diastolic dysfunction in high-fat diet fed mice is associated with lipotoxicity without impairment of cardiac energetics in vivo
- (2014) Desiree Abdurrachim et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Gigantic Business
- (2014) Wolfgang A. Linke et al. CIRCULATION RESEARCH
- Cardiac Structure and Function and Prognosis in Heart Failure With Preserved Ejection Fraction
- (2014) Amil M. Shah et al. Circulation-Heart Failure
- Targeting the unfolded protein response in heart diseases
- (2014) Man Liu et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Mitochondrial cholesterol: mechanisms of import and effects on mitochondrial function
- (2014) Laura A. Martin et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity
- (2014) Bharat Jaishy et al. JOURNAL OF LIPID RESEARCH
- The pathophysiology of heart failure with preserved ejection fraction
- (2014) Barry A. Borlaug Nature Reviews Cardiology
- CMR-Verified Diffuse Myocardial Fibrosis Is Associated With Diastolic Dysfunction in HFpEF
- (2014) Mao-Yuan M. Su et al. JACC-Cardiovascular Imaging
- Cardiac Steatosis and Left Ventricular Hypertrophy in Patients With Generalized Lipodystrophy as Determined by Magnetic Resonance Spectroscopy and Imaging
- (2013) Michael D. Nelson et al. AMERICAN JOURNAL OF CARDIOLOGY
- Hyperglycemia-Induced Secretion of Endothelial Heparanase Stimulates a Vascular Endothelial Growth Factor Autocrine Network in Cardiomyocytes That Promotes Recruitment of Lipoprotein Lipase
- (2013) Dahai Zhang et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Cardiac oxidative stress in a mouse model of neutral lipid storage disease
- (2013) Astrid Schrammel et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy
- (2013) N Fillmore et al. BRITISH JOURNAL OF PHARMACOLOGY
- Cardiac Metabolism in Heart Failure
- (2013) Torsten Doenst et al. CIRCULATION RESEARCH
- The obesity paradox in heart failure patients with preserved versus reduced ejection fraction: a meta-analysis of individual patient data
- (2013) R Padwal et al. INTERNATIONAL JOURNAL OF OBESITY
- A Novel Paradigm for Heart Failure With Preserved Ejection Fraction
- (2013) Walter J. Paulus et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Interleukin-16 Promotes Cardiac Fibrosis and Myocardial Stiffening in Heart Failure with Preserved Ejection Fraction
- (2013) Shunsuke Tamaki et al. PLoS One
- Lipotoxicity contributes to endothelial dysfunction: A focus on the contribution from ceramide
- (2013) J. David Symons et al. REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
- Calcium mishandling in diastolic dysfunction: Mechanisms and potential therapies
- (2012) Michelle L. Asp et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Carnitine Palmitoyltransferase-1b Deficiency Aggravates Pressure Overload–Induced Cardiac Hypertrophy Caused by Lipotoxicity
- (2012) Lan He et al. CIRCULATION
- Ventricular Assist Device Implantation Corrects Myocardial Lipotoxicity, Reverses Insulin Resistance, and Normalizes Cardiac Metabolism in Patients With Advanced Heart Failure
- (2012) Aalap Chokshi et al. CIRCULATION
- Low Myocardial Protein Kinase G Activity in Heart Failure With Preserved Ejection Fraction
- (2012) Loek van Heerebeek et al. CIRCULATION
- Cyclic GMP-Dependent Signaling in Cardiac Myocytes
- (2012) Eiki Takimoto CIRCULATION JOURNAL
- Cardiac-Specific Deletion of Acetyl CoA Carboxylase 2 Prevents Metabolic Remodeling During Pressure-Overload Hypertrophy
- (2012) Stephen C. Kolwicz et al. CIRCULATION RESEARCH
- Ceramide Mediates Vascular Dysfunction in Diet-Induced Obesity by PP2A-Mediated Dephosphorylation of the eNOS-Akt Complex
- (2012) Q.-J. Zhang et al. DIABETES
- Association between Serum Total Antioxidant Status and Coronary Microvascular Functions in Patients with SLE
- (2012) Sema Yılmaz et al. ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
- Obesity-Related Alterations in Cardiac Lipid Profile and Nondipping Blood Pressure Pattern during Transition to Diastolic Dysfunction in Male db/db Mice
- (2012) Vincent G. DeMarco et al. ENDOCRINOLOGY
- Diacylglycerol acyl transferase 1 overexpression detoxifies cardiac lipids in PPARγ transgenic mice
- (2012) Li Liu et al. JOURNAL OF LIPID RESEARCH
- Oxidative stress and cardiac hypertrophy: a review
- (2012) Subir Kumar Maulik et al. TOXICOLOGY MECHANISMS AND METHODS
- Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction
- (2011) Marco Guazzi et al. CIRCULATION
- Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heart
- (2011) Ethan J Anderson et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Plasma levels of tumor necrosis factor-α and interleukin-6 are associated with diastolic heart failure through downregulation of sarcoplasmic reticulum Ca2+ ATPase
- (2011) Cho-Kai Wu et al. CRITICAL CARE MEDICINE
- Chronic exposure to high fatty acids impedes receptor agonist-induced nitric oxide production and increments of cytosolic Ca2+ levels in endothelial cells
- (2011) Yanxia Tang et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Inflammation is Related to Coronary Flow Reserve Detected by Positron Emission Tomography in Asymptomatic Male Twins
- (2011) Viola Vaccarino et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Pentraxin 3 Is a New Inflammatory Marker Correlated With Left Ventricular Diastolic Dysfunction and Heart Failure With Normal Ejection Fraction
- (2011) Junichi Matsubara et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy
- (2011) Dao-Fu Dai et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Myocardial ATGL Overexpression Decreases the Reliance on Fatty Acid Oxidation and Protects against Pressure Overload-Induced Cardiac Dysfunction
- (2011) P. C. Kienesberger et al. MOLECULAR AND CELLULAR BIOLOGY
- ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
- (2011) Guenter Haemmerle et al. NATURE MEDICINE
- Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome — An allostatic perspective
- (2010) Sam Virtue et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Rescue of Cardiomyopathy in Peroxisome Proliferator-Activated Receptor-α Transgenic Mice by Deletion of Lipoprotein Lipase Identifies Sources of Cardiac Lipids and Peroxisome Proliferator-Activated Receptor-α Activators
- (2010) Jennifer G. Duncan et al. CIRCULATION
- Uncoupled Cardiac Nitric Oxide Synthase Mediates Diastolic Dysfunction
- (2010) Gad A. Silberman et al. CIRCULATION
- Cardiac Titin
- (2010) Martin M. LeWinter et al. CIRCULATION
- Cardiac Inflammation Contributes to Changes in the Extracellular Matrix in Patients With Heart Failure and Normal Ejection Fraction
- (2010) Dirk Westermann et al. Circulation-Heart Failure
- Modulation of cardiac ryanodine receptor activity by ROS and RNS
- (2010) Paulina Donoso Frontiers in Bioscience-Landmark
- Free fatty acids induce endothelial dysfunction and activate protein kinase C and nuclear factor-κB pathway in rat aorta
- (2010) Hua Li et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation
- (2010) Ni-Huiping Son et al. JOURNAL OF CLINICAL INVESTIGATION
- Myocardial Fatty Acid Metabolism in Health and Disease
- (2010) Gary D. Lopaschuk et al. PHYSIOLOGICAL REVIEWS
- Modulation of Titin-Based Stiffness by Disulfide Bonding in the Cardiac Titin N2-B Unique Sequence
- (2009) Anika Grützner et al. BIOPHYSICAL JOURNAL
- Proteomic remodelling of mitochondrial oxidative pathways in pressure overload-induced heart failure
- (2009) Heiko Bugger et al. CARDIOVASCULAR RESEARCH
- Harmonizing the Metabolic Syndrome
- (2009) K.G.M.M. Alberti et al. CIRCULATION
- Hypophosphorylation of the Stiff N2B Titin Isoform Raises Cardiomyocyte Resting Tension in Failing Human Myocardium
- (2009) Attila Borbély et al. CIRCULATION RESEARCH
- Insulin-Stimulated Cardiac Glucose Oxidation Is Increased in High-Fat Diet-Induced Obese Mice Lacking Malonyl CoA Decarboxylase
- (2009) J. R. Ussher et al. DIABETES
- Myocardial lipid accumulation in patients with pressure-overloaded heart and metabolic syndrome
- (2009) Raffaele Marfella et al. JOURNAL OF LIPID RESEARCH
- Altered Myocardial Substrate Metabolism and Decreased Diastolic Function in Nonischemic Human Diabetic Cardiomyopathy
- (2009) Luuk J. Rijzewijk et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Peroxynitrite increases protein phosphatase activity and promotes the interaction of phospholamban with protein phosphatase 2a in the myocardium
- (2009) Mark J. Kohr et al. NITRIC OXIDE-BIOLOGY AND CHEMISTRY
- Heart Failure With Preserved and Reduced Left Ventricular Ejection Fraction in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
- (2008) Barry R. Davis et al. CIRCULATION
- Ceramide is a cardiotoxin in lipotoxic cardiomyopathy
- (2008) Tae-Sik Park et al. JOURNAL OF LIPID RESEARCH
- Lentiviral Vector–mediated SERCA2 Gene Transfer Protects Against Heart Failure and Left Ventricular Remodeling After Myocardial Infarction in Rats
- (2008) Kazuo Niwano et al. MOLECULAR THERAPY
- Diastolic Stiffness of the Failing Diabetic Heart
- (2007) Loek van Heerebeek et al. CIRCULATION
- Prognosis of heart failure with preserved ejection fraction: a 5 year prospective population-based study
- (2007) C. Tribouilloy et al. EUROPEAN HEART JOURNAL
- Progressive Caloric Restriction Induces Dose-Dependent Changes in Myocardial Triglyceride Content and Diastolic Function in Healthy Men
- (2007) Sebastiaan Hammer et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started