Electroreductive Cross‐Coupling of Trifluoromethyl Alkenes and Redox Active Esters for the Synthesis of Gem ‐Difluoroalkenes

Single Electron Transfer-Induced Redox Processes Involving N-(Acyloxy)phthalimides

(2021) Sushanta Kumar Parida et al.   ACS Catalysis

Photocatalytic Deoxygenative Carboimination towards Functionalized Pyrrolines by Using Unstrained γ , δ ‐Unsaturated Oximes

(2021) Min Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

Photoredox/Hydrogen Atom Transfer Cocatalyzed C–H Difluoroallylation of Amides, Ethers, and Alkyl Aldehydes

(2021) Yuan-Qiang Guo et al.   ORGANIC LETTERS

Site-Selective Defluorinative sp3 C–H Alkylation of Secondary Amides

(2021) Wen-Jun Yue et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Remote Regioselective Radical C–H Functionalization of Unactivated C–H Bonds in Amides: The Synthesis of gem-Difluoroalkenes

(2021) Qu-Ping Hu et al.   ORGANIC LETTERS

Chromium-Catalyzed Allylic Defluorinative Ketyl Olefin Coupling

(2021) Chang Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electrochemical Nozaki–Hiyama–Kishi Coupling: Scope, Applications, and Mechanism

(2021) Yang Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photoredox Generation of N-Centered Hydrazonyl Radicals Enables the Construction of Dihydropyrazole-Fused gem-Difluoroalkenes

(2021) Qi-Sheng Gao et al.   ORGANIC LETTERS

Electrochemical borylation of carboxylic acids

(2021) Lisa M. Barton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NiH-Catalyzed Migratory Defluorinative Olefin Cross-Coupling: Trifluoromethyl-Substituted Alkenes as Acceptor Olefins to Form gem -Difluoroalkenes

(2020) Fenglin Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalyzing the Hydrodefluorination of CF3-Substituted Alkenes by PhSiH3. H• Transfer from a Nickel Hydride

(2020) Chengbo Yao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electrochemical Intramolecular Oxytrifluoromethylation of N-Tethered Alkenyl Alcohols: Synthesis of Functionalized Morpholines

(2020) Aurélie Claraz et al.   ORGANIC LETTERS

Visible-Light-Mediated β-C–H gem-Difluoroallylation of Aldehydes and Cyclic Ketones through C–F Bond Cleavage of 1-Trifluoromethyl Alkenes

(2020) Devireddy Anand et al.   ORGANIC LETTERS

Visible-Light-Induced Deoxygenation/Defluorination Protocol for Synthesis of γ,γ-Difluoroallylic Ketones

(2020) Yuan-Qiang Guo et al.   ORGANIC LETTERS

Umpolung Difunctionalization of Carbonyls via Visible-Light Photoredox Catalytic Radical-Carbanion Relay

(2020) Shun Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Titanocene-Catalyzed Reductive Domino Epoxide Ring Opening/Defluorinative Cross-Coupling Reaction

(2020) Zhiyang Lin et al.   ORGANIC LETTERS

Deuteriodifluoromethylation and gem ‐Difluoroalkenylation of Aldehydes Using ClCF 2 H in Continuous Flow

(2020) Wai Chung Fu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advances in Electrochemical Decarboxylative Transformation Reactions

(2020) Velayudham Ramadoss et al.   CHEMISTRY-A EUROPEAN JOURNAL

Merger of C–F and C–N Bond Cleavage in Cross-Electrophile Coupling for the Synthesis of gem-Difluoroalkenes

(2020) Youxiang Jin et al.   ORGANIC LETTERS

Radical‐Based Synthesis and Modification of Amino Acids

(2020) Francisco José Aguilar Troyano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alkyltriflones in the Ramberg–Bäcklund Reaction: An Efficient and Modular Synthesis of gem-Difluoroalkenes

(2020) Yuuki Maekawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Electrochemical Defluorinative Carboxylation of gem-Difluoroalkenes with Carbon Dioxide

(2020) Shi-Liang Xie et al.   ORGANIC LETTERS

Manganese-mediated reductive functionalization of activated aliphatic acids and primary amines

(2020) Zhan Li et al.   Nature Communications

Recent Developments in Deaminative Functionalization of Alkyl Amines

(2020) Yi‐Na Li et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of gem-Difluoroalkenes via Zn-Mediated Decarboxylative/Defluorinative Cross-Coupling

(2020) Hai-Wu Du et al.   ORGANIC LETTERS

Photoredox Defluorinative Alkylation of 1‐Trifluoromethyl Alkenes and 1,3‐Butadienes with 1,4‐Dihydropyridines as Alkylation Reagents

(2019) Haoguo Chen et al.   Asian Journal of Organic Chemistry

Synthesis of gem-Difluoroalkenes by Merging Ni-Catalyzed C–F and C–C Bond Activation in Cross-Electrophile Coupling

(2019) Decai Ding et al.   ORGANIC LETTERS

One-Pot Electrochemical Nickel-Catalyzed Decarboxylative Sp2–Sp3 Cross-Coupling

(2019) Takaoki Koyanagi et al.   ORGANIC LETTERS

Open-Air Alkylation Reactions in Photoredox-Catalyzed DNA-Encoded Library Synthesis

(2019) James P. Phelan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Synthesis of α-Trifluoromethyl Carboxylic Acids and Esters via Fluorocarboxylation of gem-Difluoroalkenes

(2019) Woo-Jin Yoo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible-Light-Promoted Redox Neutral γ,γ-Difluoroallylation of Cycloketone Oxime Ethers with Trifluoromethyl Alkenes via C–C and C–F Bond Cleavage

(2019) Yuwei He et al.   ORGANIC LETTERS

Photocatalytic, Phosphoranyl Radical-Mediated N–O Cleavage of Strained Cycloketone Oximes

(2019) Peng-Ju Xia et al.   ORGANIC LETTERS

Defluorinative C(sp 3 )−P Bond Construction for the Synthesis of Phosphorylation gem ‐Difluoroalkenes under Catalyst‐ and Oxidant‐Free Conditions

(2019) Congyu Li et al.   Chemistry-An Asian Journal

Pyridinium Salts as Redox-Active Functional Group Transfer Reagents

(2019) Antonio Togni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pyrylium Salts: Selective Reagents for the Activation of Primary Amino Groups in Organic Synthesis

(2019) Yue Pang et al.   SYNTHESIS-STUTTGART

Visible-Light-Induced Selective Defluoroborylation of Polyfluoroarenes, gem -Difluoroalkenes, and Trifluoromethylalkenes

(2019) Wengang Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalyst‐Free Decarboxylation of Carboxylic Acids and Deoxygenation of Alcohols by Electro‐Induced Radical Formation

(2019) Xiaoping Chen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Coupling of Trifluoroacetaldehyde N-Triftosylhydrazone with Organoboronic Acids for the Synthesis of gem-Difluoroalkenes

(2019) Yu Ma et al.   ORGANIC LETTERS

Transition Metal-Mediated and -Catalyzed C-F Bond Activation via Fluorine Elimination

(2018) Takeshi Fujita et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Copper-Catalyzed Reductive Defluorination of β-Trifluoromethylated Enones via Oxidative Homocoupling of Grignard Reagents

(2018) Xiaoting Wu et al.   ORGANIC LETTERS

Ni-Catalyzed Electrochemical Decarboxylative C–C Couplings in Batch and Continuous Flow

(2018) Hui Li et al.   ORGANIC LETTERS

Cu-Catalyzed tertiary alkylation of α-(trifluoromethyl)styrenes with tertiary alkylmagnesium reagents

(2018) Wenpeng Dai et al.   Organic Chemistry Frontiers

Synthesis of gem-Difluoroalkenes via Nickel-Catalyzed Allylic Defluorinative Reductive Cross-Coupling

(2018) Yun Lan et al.   ACS Catalysis

Synthesis of gem-Difluoroalkenes via Nickel-Catalyzed Reductive C–F and C–O Bond Cleavage

(2018) Zhiyang Lin et al.   ACS Catalysis

Synthesis of gem-Difluoroallylboronates via FeCl2-Catalyzed Boration/β-Fluorine Elimination of Trifluoromethyl Alkenes

(2017) Yang Liu et al.   ORGANIC LETTERS

Recent advances in the synthesis and CF functionalization of gem-difluoroalkenes

(2017) Xuxue Zhang et al.   TETRAHEDRON LETTERS

Direct Difluoromethylenation of Carbonyl Compounds by Using TMSCF3: The Right Conditions

(2016) Sankarganesh Krishnamoorthy et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Functionalized gem-Difluoroalkenes via a Photocatalytic Decarboxylative/Defluorinative Reaction

(2016) Tiebo Xiao et al.   JOURNAL OF ORGANIC CHEMISTRY

Rhodium-Catalyzed Asymmetric Arylation/Defluorination of 1-(Trifluoromethyl)alkenes Forming Enantioenriched 1,1-Difluoroalkenes

(2016) Yinhua Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Decarboxylative Cross-Electrophile Coupling of N-Hydroxyphthalimide Esters with Aryl Iodides

(2016) Kierra M. M. Huihui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visible-Light Photoredox Synthesis of Chiral α-Selenoamino Acids

(2016) Min Jiang et al.   ORGANIC LETTERS

A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents

(2016) T. Qin et al.   SCIENCE

Visible-light photoredox synthesis of unnatural chiral α-amino acids

(2016) Min Jiang et al.   Scientific Reports

Reaction of Diazo Compounds with Difluorocarbene: An Efficient Approach towards 1,1-Difluoroolefins

(2015) Zhikun Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

gem-Difluoroolefination of Diazo Compounds with TMSCF3 or TMSCF2Br: Transition-Metal-Free Cross-Coupling of Two Carbene Precursors

(2015) Mingyou Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of (Trifluoromethyl)zinc Reagent as Trifluoromethyl Anion and Difluorocarbene Sources

(2015) Kohsuke Aikawa et al.   ORGANIC LETTERS

Cross-Coupling between Difluorocarbene and Carbene-Derived Intermediates Generated from Diazocompounds for the Synthesis of gem-Difluoroolefins

(2015) Jian Zheng et al.   ORGANIC LETTERS

Nickel-Catalyzed Allylic C(sp3)–F Bond Activation of Trifluoromethyl Groups via β-Fluorine Elimination: Synthesis of Difluoro-1,4-dienes

(2015) Tomohiro Ichitsuka et al.   ACS Catalysis

Difluoromethyl 2-pyridyl sulfone: a versatile carbonyl gem-difluoroolefination reagent

(2015) Bing Gao et al.   Organic Chemistry Frontiers

Functionalization of Fluorinated Molecules by Transition-Metal-Mediated C–F Bond Activation To Access Fluorinated Building Blocks

(2014) Theresia Ahrens et al.   CHEMICAL REVIEWS

gem-Difluoroolefination of Diaryl Ketones and Enolizable Aldehydes with Difluoromethyl 2-Pyridyl Sulfone: New Insights into the Julia-Kocienski Reaction

(2014) Bing Gao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and decarboxylative Wittig reaction of difluoromethylene phosphobetaine

(2013) Jian Zheng et al.   CHEMICAL COMMUNICATIONS

Copper-Catalyzed gem-Difluoroolefination of Diazo Compounds with TMSCF3 via C–F Bond Cleavage

(2013) Mingyou Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NHC-Cu-Catalyzed Enantioselective Hydroboration of Acyclic and Exocyclic 1,1-Disubstituted Aryl Alkenes

(2011) Rosa Corberán et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Difluoromethyl 2-Pyridyl Sulfone: A Newgem-Difluoroolefination Reagent for Aldehydes and Ketones

(2010) Yanchuan Zhao et al.   ORGANIC LETTERS

C−F Bond Activation in Organic Synthesis

(2009) Hideki Amii et al.   CHEMICAL REVIEWS

Isocombretastatins A versus Combretastatins A: The ForgottenisoCA-4 Isomer as a Highly Promising Cytotoxic and Antitubulin Agent

(2009) Samir Messaoudi et al.   JOURNAL OF MEDICINAL CHEMISTRY