Human carboxylesterase 1A plays a predominant role in the hydrolytic activation of remdesivir in humans

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Weinreb Amide Approach to the Practical Synthesis of a Key Remdesivir Intermediate

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Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells

(2021) Ruidong Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

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Rational design and development of a novel and highly specific near-infrared fluorogenic substrate for sensing and imaging of human pancreatic lipase in living systems

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Computational Simulations to Guide Enzyme-Mediated Prodrug Activation

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Bioluminescent Sensor Reveals that Carboxylesterase 1A is a Novel Endoplasmic Reticulum-Derived Serologic Indicator for Hepatocyte Injury

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Clinical retrospective study on the efficacy of Qingfei Paidu decoction combined with Western medicine for COVID-19 treatment

(2020) Siyi Xin et al.   BIOMEDICINE & PHARMACOTHERAPY

Deciphering the metabolic fates of a green fluorescent protein (GFP)-like fluorophore: Metabolite identification, isoenzyme contribution and species differences

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Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19

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Off-Target In Vitro Profiling Demonstrates that Remdesivir Is a Highly Selective Antiviral Agent

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Design, synthesis and biological evaluation of novel chalcone-like compounds as potent and reversible pancreatic lipase inhibitors

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Design, synthesis and biological evaluation of indanone–chalcone hybrids as potent and selective hCES2A inhibitors

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Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report

(2020) Matthew S. Buckland et al.   Nature Communications

Challenges and stepwise fit-for-purpose optimization for bioanalyses of remdesivir metabolites nucleotide monophosphate and triphosphate in mouse tissues using LC–MS/MS

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In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites

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Discovery of natural pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1

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The influence of carboxylesterase 1 polymorphism and cannabidiol on the hepatic metabolism of heroin

(2019) Yuli Qian et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Nongenetic Regulators

(2019) Lucy Her et al.   DRUG METABOLISM AND DISPOSITION

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Carboxylesterase Inhibitors: An Update

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Involvement of CYP4F2 in the Metabolism of a Novel Monophosphate Ester Prodrug of Gemcitabine and Its Interaction Potential In Vitro

(2018) Yedong Wang et al.   MOLECULES

Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1

(2018) Ya-Qiao Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

A bioluminescent sensor for highly selective and sensitive detection of human carboxylesterase 1 in complex biological samples

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Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

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Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors

(2015) Gabriel Birkus et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Implications of Efficient Hepatic Delivery by Tenofovir Alafenamide (GS-7340) for Hepatitis B Virus Therapy

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Carboxylesterase 1-Mediated Drug–Drug Interactions between Clopidogrel and Simvastatin

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Carboxylesterase 2 production and characterization in human cells: new insights into enzyme oligomerization and activity

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Covalent inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by the carbamates JZL184 and URB597

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The effect of carboxylesterase 1 (CES1) polymorphisms on the pharmacokinetics of oseltamivir in humans

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In Vitro Evaluation of Inhibitory Effects of Antidiabetic and Antihyperlipidemic Drugs on Human Carboxylesterase Activities

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Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977

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Structural Organization and Characterization of the Regulatory Element of the Human Carboxylesterase (CES1A1 and CES1A2) genes

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Structure and Catalytic Properties of Carboxylesterase Isozymes Involved in Metabolic Activation of Prodrugs

(2008) Masakiyo Hosokawa   MOLECULES

Structure and characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes

(2008) Tatsuki Fukami et al.   Pharmacogenetics and Genomics